More info
Active ingredients
Hymekromon
Release form
Pills
Composition
7-hydroxy-4-methylcoumarin (hymecromone) 0.2 g; Auxiliary components: starch, gelatin, magnesium stearate, sodium dodecyl sulfate.
Pharmacological effect
Choleretic
Pharmacokinetics
Gimecromone is a derivative of coumarin. Under its influence increases the synthesis of bile, accelerated its evacuation into the intestinal lumen. Acceleration of bile secretion is due to the selective removal of spasm from the sphincter of Oddi and the smooth muscle of the bile ducts. Effect on peristalsis Odeston not noted. The effect of the drug was not fixed on the tone of smooth muscle tissues of the vascular walls. Odeston eliminates cholestasis, does not allow cholesterol to crystallize. The volume of secreted bile increases, it increases the content of acids, cholesterol. This increases the activity of pancreatic lipase and contributes to the full emulsification of fats and their resorption.
Indications
- Dyskinesia of biliary tract; - Hyperkinesia of the sphincter of Oddi; - non-calculous cholecystitis; - chronic cholangitis; - conditions accompanying patients after operations on the liver, gall bladder; - chronic constipation caused by bile hyposecretion; - lack of appetite, dyspepsia on the background of bile hyposecretion.
Contraindications
Do not prescribe Odeston when: - liver failure; - obstruction of the gallbladder; - renal failure; - ulcerative colitis; - ulcerative lesions of the stomach; - hypersensitivity to coumarins, auxiliary components of Odeston pills; - Crohn's disease; - hemophilia; - lactation; - duodenal ulcer .; Not shown Odeston in childhood.
Use during pregnancy and lactation
The appointment of Odeston to pregnant women is possible in exceptional cases when the doctor has weighed the mother's benefit / risk ratio for the fetus and has determined that it cannot be dispensed with. Clinical trials for pregnant women were not conducted.
Dosage and administration
Taking pills to ensure therapeutic action should occur before meals (30 minutes.). Standard appointment: 3 tab. / Day. It is possible to increase the daily dosage of hymecromone to 1.2 g (6 pills / day). The division of the daily dose is carried out in three doses. The treatment course is 14 days.
Side effects
When using Odeston, the appearance of: - diarrhea; - urticaria; - epigastric pain; - anaphylaxis; - ulceration of the gastrointestinal tract; - meteorism; - headaches.
Overdose
The dosage to exceed undesirable because of the possibility of enhancing side effects. There are no officially registered cases of overdose.
Interaction with other drugs
Odeston enhances the effectiveness of antithrombotic agents, phylloquinone antagonists. Morphine weakens the antispasmodic effect of hymecromone, as it has a strong spasm effect against the sphincter of Oddi. When prescribed with metoclopramide, its derivatives, mutual efficacy is observed.
special instructions
Does not impair the secretory function of the digestive glands and intestinal absorption processes .; Influence on the ability to drive motor vehicles and control mechanisms; The drug does not affect the ability to drive vehicles and engage in other potentially dangerous activities that require high concentration of attention and speed of psychomotor reactions.