Omnitus pills with mod. Coated with 20mg N10
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Active ingredients
Butamirate
Release form
Pills
Composition
Butamirate citrate 20 mg. Auxiliary substances: lactose monohydrate - 218.5 mg, hypromellose - 70 mg, talc - 10 mg, magnesium stearate - 8 mg, anhydrous colloidal silicon dioxide - 2 mg, povidone - 1.5 mg.
Pharmacological effect
Antitussive drug of central action. Butamirate citrate is neither chemically nor pharmacologically related to opium alkaloids. It has a direct effect on the cough center. It has an expectorant, moderate bronchodilatory and anti-inflammatory effect. Improves spirometry and blood oxygenation.
Pharmacokinetics
Absorption: After oral absorption is high. After ingestion of the drug in the form of a syrup at a dose of 150 mg Cmax in the plasma of the main metabolite (2-phenylbutyric acid) is observed after 1.5 hours and amounts to 6.4 μg / ml, while taking a release tablet (50 mg), respectively, 9 h and 1.4 μg / ml. Distribution and Metabolism: Butamirate citrate is rapidly hydrolyzed in plasma to 2-phenyl butyric acid and diethylaminoethoxyethanol. Both of these metabolites, which also have an antitussive effect, are largely associated with plasma proteins, which explains their long-term presence in the plasma. Subsequently, the main metabolite 2-phenylbutyric acid is oxidized to 14C-p-hydroxy-2-phenylbutyric acid. Does not accumulate. Withdrawal: T1 / 2 of butamirate when taking the drug in the form of a syrup is 6 hours, in the form of pills -13 hours. All three metabolites are excreted by the kidneys, with acidic metabolites mainly in the form of glucuronides.
Indications
- dry cough of any etiology (for colds, flu, whooping cough and other conditions) - to suppress cough in the preoperative and postoperative period, during surgical interventions, bronchoscopy.
Contraindications
- lactation period - hypersensitivity to the drug components. For pills: - pregnancy - children up to 6 years old (20 mg pills) - children and adolescents up to 18 years (50 mg pills). For syrup: - I trimester of pregnancy - children up to 3 years.
Dosage and administration
The drug is prescribed inside. Tablets 20 mg: Adults appoint 2 pills. 2-3 times / day; children over 12 years old - 1 tab. 3 times / day; children aged 6 to 12 years - 1 tab. 2 times / day. Tablets 50 mg: Adults appoint 1 tab. every 8-12 hoursTablets are taken before meals without chewing. Syrup: Adults appoint 6 scoops (30 ml) 3 times / day; children over 9 years old (body weight from 40 kg) - 3 measuring spoons (15 ml) 4 times / day; children aged 6 to 9 years (body weight 22-30 kg) - 3 measuring spoons (15 ml) 3 times / day; children aged 3 to 6 years (body weight 15-22 kg) - 2 measuring spoons (10 ml) 3 times / day.