Ondansetron solution for intravenous and intramuscular administration of 2 mg ml 4 ml N5
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Active ingredients
Ondansetron
Release form
Solution
Composition
1 ml of ondansetron (in the form of dihydrate hydrochloride) 2 mg. Excipients: disodium edetate dihydrate - 1.5 mg, sodium hydroxide - 0.2-1 mg.
Pharmacological effect
Antiemetic. Effectively prevents and eliminates nausea and vomiting that occur during antitumor chemotherapy or radiation therapy, as well as in the postoperative period. The mechanism of action is due to the ability of ondansetron to selectively block serotonin 5-HT3 receptors. It is believed that in the occurrence of nausea and vomiting during antitumor therapy an important role is played by stimulation of the afferent fibers of the vagus nerve with serotonin released from the enterochromaffin cells of the gastrointestinal mucosa. By blocking 5-HT3 receptors, ondansetron prevents the occurrence of gag reflex. In addition, ondansetron inhibits the central links of the gag reflex, blocking 5-HT3 receptors of the bottom of the IV ventricle (area postrema).
Indications
Prevention of nausea and vomiting during antitumor chemotherapy or radiation therapy. prevention and treatment of nausea and vomiting in the postoperative period.
Contraindications
I trimester of pregnancy, hypersensitivity to ondansetron.
Use during pregnancy and lactation
Ondansetron is contraindicated for use in the first trimester of pregnancy. If necessary, use during lactation should stop breastfeeding.
Dosage and administration
Individual, depending on the indications and treatment regimen.
Side effects
From the side of the central nervous system: headaches. rarely, transient visual disturbances and dizziness (with rapid IV injection), involuntary movements. Since the cardiovascular system: rarely - chest pain, arrhythmias, bradycardia, arterial hypotension. On the part of the digestive system: constipation, diarrhea, abdominal pain, transient increase in serum transaminase levels. Allergic reactions: rarely - bronchospasm, angioedema, urticaria. in some cases - anaphylactic reactions. Other: a feeling of warmth and rush of blood to the head and epigastric region.
special instructions
From the side of the central nervous system: headaches. rarely, transient visual disturbances and dizziness (with rapid IV injection), involuntary movements. Since the cardiovascular system: rarely - chest pain, arrhythmias, bradycardia, arterial hypotension.On the part of the digestive system: constipation, diarrhea, abdominal pain, transient increase in serum transaminase levels. Allergic reactions: rarely - bronchospasm, angioedema, urticaria. in some cases - anaphylactic reactions. Other: a feeling of warmth and rush of blood to the head and epigastric region.