Pancef granules for the preparation of suspensions for the preparation of BH 100mg 5ml 53g
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Active ingredients
Cefixime
Composition
Granules for the preparation of suspensions for ingestion of 5 ml of the prepared suspension. cefixime 100 mg.
Pharmacological effect
Semisynthetic cephalosporin III generation antibiotic for oral administration of a wide spectrum of action. Bactericidal effect. The mechanism of action is due to inhibition of the synthesis of the cell membrane of the pathogen. Cefixime is resistant to the action of & # 946.-Lactamase, produced by most gram-positive and gram-negative bacteria. In vitro, cefixime is active against gram-positive bacteria: Streptococcus agalactiae. Gram-negative bacteria: Haemophilus parainfluenzae, Proteus vulgaris, Klebsiella pneumoniae, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus, Citrobacter diversus-synsus, an example, Syro. In vitro and in clinical practice, cefixime is active against gram-positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes. Gram-negative bacteria: Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae. Cefixime is resistant to Pseudomonas spp., Enterococcus (Streptococcus) serogroup D, Listeria monocytogenes, most of Staphylococcus spp. (including methicillin-resistant strains), Enterobacter spp., Bacteroides fragilis, Clostridium spp.
Indications
Infectious and inflammatory diseases caused by susceptible microorganisms: pharyngitis, tonsillitis, sinusitis, acute and chronic bronchitis, otitis media, uncomplicated urinary tract infections, uncomplicated gonorrhea.
Contraindications
Hypersensitivity to cephalosporins and penicillins.
Use during pregnancy and lactation
Use during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus. If necessary, use during lactation should stop breastfeeding.
Dosage and administration
For adults and children over 12 years old with a body weight of more than 50 kg, the daily dose is 400 mg (1 time / day or 200 mg 2 times / day). Duration of treatment is 7-10 days. With uncomplicated gonorrhea - 400 mg once. Children under 12 years old - 8 mg / kg of body weight 1 time / day or 4 mg / kg every 12 hours. For infections caused by Streptococcus pyogenes, the treatment should be at least 10 days. In cases of impaired renal function (with CC from 21 to 60 ml / min) or in patients on hemodialysis, the daily dose should be reduced by 25%. With QC & # 8804 .20 ml / min or in patients on peritoneal dialysis, the daily dose should be reduced by 2 times.
Side effects
On the part of the digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, flatulence, a transient increase in the activity of hepatic transaminases and alkaline phosphatase, hyperbilirubinemia,jaundice, gastrointestinal candidiasis, dysbacteriosis. rarely - stomatitis, glossitis, pseudomembranous enterocolitis. From the hematopoietic system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia. From the side of the central nervous system: dizziness, headache. On the part of the urinary system: interstitial nephritis. Allergic reactions: pruritus, urticaria, skin flushing, eosinophilia, fever.
special instructions
On the part of the digestive system: dry mouth, anorexia, diarrhea, nausea, vomiting, abdominal pain, flatulence, a transient increase in liver transaminases and alkaline phosphatase, hyperbilirubinemia, jaundice, candidiasis of the gastrointestinal tract, dysbacteriosis. rarely - stomatitis, glossitis, pseudomembranous enterocolitis. From the hematopoietic system: leukopenia, thrombocytopenia, neutropenia, hemolytic anemia. From the side of the central nervous system: dizziness, headache. On the part of the urinary system: interstitial nephritis. Allergic reactions: pruritus, urticaria, skin flushing, eosinophilia, fever.