Ribavirin Verte capsules 200mg N30
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Active ingredients
Ribavirin
Release form
Capsules
Composition
Ribavirin 200 mg
Pharmacological effect
Antiviral agent. It quickly enters cells and acts inside cells infected with a virus. Intracellular ribavirin is easily phosphorylated by adenosine kinase to mono-, di-, and triphosphate metabolites. Ribavirin triphosphate is a strong competitive inhibitor of inosine monophosphate dehydrogenase, influenza virus RNA polymerase and guanylyl transferase messenger RNA, the latter is manifested by the inhibition of the messenger RNA coating process. These diverse effects lead to a significant reduction in the amount of intracellular guanosine triphosphate, as well as suppression of the synthesis of viral RNA and protein. Ribavirin inhibits the replication of new virions, which ensures a reduction in viral load, selectively inhibits the synthesis of viral RNA without inhibiting the synthesis of RNA in normally functioning cells .; The most active against DNA viruses - respiratory syncytial virus, Herpes simplex virus types 1 and 2, adenoviruses, CMV, smallpox viruses, Marek's disease; RNA viruses - influenza A, B viruses, paramyxoviruses (parainfluenza, mumps, afflicted to infants), reus viruses, arenaviruses (Lassa fever virus, Bolivian hemorrhagic fever), bunyaviruses (Rift virus, Rift virus, and in and out and in and out and in and in; (hemorrhagic fever virus with renal or pulmonary syndrome) paramyxoviruses, oncogenic RNA viruses .; When treating hemorrhagic fever with renal syndrome, reduces the severity of the disease, reduces the duration of symptoms (fever, oliguria, pain in the lumbar region, abdomen, headache), improves laboratory indicators of renal function, reduces the risk of hemorrhagic complications and adverse outcome of the disease .; DNA viruses are not sensitive to ribavirin - Varicella zoster, pseudo-rabies virus, cowpox; RNA viruses - enteroviruses, rhinoviruses, encephalitis virus of the Semliki forest.
Indications
For oral administration: treatment of chronic hepatitis C in adults (in combination with interferon alfa-2b or peginterferon alfa-2b) .; Parenteral: hemorrhagic fever with renal syndrome .; Outwardly as monotherapy or in combination with other dosage forms of ribavirin for oral administration and parenteral use: infections of the skin and mucous membranes caused by Herpes simplex viruses 1 and 2 types, of various localization, incl.in the genital area; herpes zoster (as part of complex therapy).
Contraindications
Chronic heart failure IIB-III stage, myocardial infarction, renal failure (CC less than 50 ml / min), severe anemia, severe liver failure, decompensated liver cirrhosis, autoimmune diseases (including autoimmune hepatitis), non-treatable thyroid disease glands, severe depression with suicidal tendencies, children and adolescents under 18 years of age, pregnancy, lactation, sensitivity to ribavirin.
Use during pregnancy and lactation
Ribavirin is contraindicated for use during pregnancy and lactation (breastfeeding).
Dosage and administration
Individual, depending on the evidence, age, regimen of application, dosage form.
Side effects
On the part of the central nervous system and peripheral nervous system: headache, dizziness, weakness, malaise, insomnia, asthenia, depression, irritability, anxiety, emotional lability, nervousness, agitation, aggressive behavior, confusion; rarely - suicidal tendency, smooth muscle tone, tremor, paresthesias, hyperesthesia, hypoesthesia, syncope .; Since the cardiovascular system: decrease or increase in blood pressure, brady- or tachycardia, palpitations, cardiac arrest .; From the side of blood-forming organs: hemolytic anemia, leukopenia, neutropenia, granulocytopenia, thrombocytopenia; extremely rarely - aplastic anemia .; On the part of the respiratory system: dyspnea, cough, pharyngitis, shortness of breath, bronchitis, otitis media, sinusitis, rhinitis .; On the part of the digestive system: dry mouth, decreased appetite, nausea, vomiting, diarrhea, abdominal pain, constipation, taste perversion, pancreatitis, flatulence, stomatitis, glossitis, gingival bleeding, hyperbilirubinemia .; On the part of the senses: damage to the lacrimal gland, conjunctivitis, blurred vision, impairment / loss of hearing, tinnitus .; On the part of the musculoskeletal system: arthralgia, myalgia .; On the part of the genitourinary system: hot flashes, decreased libido, dysmenorrhea, amenorrhea, menorrhagia, prostatitis .; Allergic reactions: skin rash, erythema, urticaria, hyperthermia, angioedema, bronchospasm, anaphylaxis,photosensitization, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis; with a / in the introduction - chills .; Local reactions: pain at the injection site .; Other: hair loss, alopecia, impaired hair structure, dry skin, hypothyroidism, chest pain, thirst, fungal infection, viral infection (including herpes), flu-like syndrome, sweating, lymphadenopathy. Medical professionals performing inhalation may have headache, itching, eye flushing, or eyelid swelling.
Overdose
Symptoms: may increase the severity of side effects .; Treatment: removal of the drug, conducting symptomatic therapy.
Interaction with other drugs
The possibility of a medicinal or other type of interaction with ribavirin can last up to two months (5 periods of T1 / 2 ribavirin) after discontinuing its use due to delayed elimination .; With simultaneous use of interferon increases therapeutic efficacy .; With simultaneous use with ribavirin may decrease the effectiveness of stavudine and zidovudine.
special instructions
To apply only in the conditions of a hospital with specialized resuscitation department. The use of ribavirin in patients who require mechanical ventilation is possible only by specialists with experience in resuscitation measures .; Use with caution in women of reproductive age (pregnancy is undesirable), in patients with decompensated diabetes mellitus (with attacks of ketoacidosis), in COPD, pulmonary embolism, chronic heart failure, in thyroid diseases (including in thyrotoxicosis), in case of coagulation disorders, thrombophlebitis, myelodepression, hemoglobinopathy (including thalassemia, sickle cell anemia), depression, suicidal tendencies (including history), concomitant HIV infection (against the background of a combination of highly active antiretroviral therapy - the risk of developing lactic acidosis) in elderly patients .; Medical personnel using ribavirin should take into account its teratogenicity.