Rimantadine actitab-OBL pills 50mg N20
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Active ingredients
Rimantadine
Release form
Pills
Composition
Rimantadine hydrochloride 50 mg.
Pharmacological effect
Rimantadine Aktivit - antiviral agent. Prevention and early treatment of influenza in adults and children over 7 years old, prevention of influenza during epidemics in adults, prevention of tick-borne encephalitis of viral etiology.
Pharmacokinetics
After ingestion, it is slowly, almost completely absorbed in the intestine. Plasma protein binding is about 40%. Vd in adults - 17-25 l / kg, in children - 289 l. Concentration in nasal secretion is 50% higher than plasma. The value of Cmax when taking 100 mg 1 time / day - 181 ng / ml, 100 mg 2 times / day - 416 ng / ml. Metabolized in the liver. T1 / 2 - 24-36 h; excreted by the kidneys (15% - unchanged, 20% - as hydroxyl metabolites). With chronic renal failure, T1 / 2 increases by 2 times. In patients with renal insufficiency and in elderly people, it can accumulate in toxic concentrations, if the dose is not adjusted in proportion to the decrease in CC.
Indications
Early treatment and prevention of influenza A in adults and children over 7 years old.
Contraindications
Acute liver diseases, acute and chronic kidney diseases, thyrotoxicosis, pregnancy, children under 7 years old, hypersensitivity to rimantadine.
Use during pregnancy and lactation
Contraindicated in pregnancy.
Dosage and administration
Inside (after eating), drinking water, according to the following scheme: Adults are prescribed on the first day of the disease 100 mg 3 times; on the second and third days you can take 100 mg 2 times; on the fourth day, 100 mg once. On the first day of the disease, it is possible to use the drug once at a dose of 300 mg. Children from 7 to 10 years old are prescribed 50 mg 2 times a day; 11-14 years 50 mg 3 times a day. Treatment of influenza A should begin within 24-48 hours after the onset of symptoms of the disease and continue for 5-7 days. The optimal duration is not established. For the prevention of influenza in adults, 50 mg is administered 1 time per day for 10-15 days, depending on the focus of infection. nursing homes - 100 mg 1 time per day.
Side effects
On the part of the digestive system: epigastric pain, flatulence,increased bilirubin in the blood, dry mouth, anorexia, nausea, vomiting, gastralgia. For CNS: headache, insomnia, nervousness, dizziness, impaired concentration, drowsiness, anxiety, irritability, fatigue. Others: allergic reactions.
Overdose
Currently no data available.
Interaction with other drugs
With the simultaneous use of rimantadine reduces the effectiveness of anti-epileptic drugs. Adsorbents, astringents and coating agents reduce the absorption of rimantadine. Means that acidify urine (ammonium chloride, ascorbic acid), reduce the effectiveness of rimantadine (due to increased its excretion by the kidneys). sodium bicarbonate) increase its effectiveness (reduced excretion by the kidneys). Paracetamol and acetylsalicylic acid reduce Cmax of rimantadine by 11%. Cimetidine with izhaet rimantadine clearance by 18%.
special instructions
Compared with amantadine, it has a higher clinical efficacy and is less toxic. The appearance of drug-resistant viruses is possible. With influenza A caused by virus B, rimantadine has an antitoxic effect. With rimantadine, exacerbation of chronic comorbidities is possible. Elderly patients with arterial hypertension increase the risk of hemorrhagic stroke. With instructions in the history of epilepsy and ongoing anticonvulsant therapy against the background of the use of rimantadine increases the risk of developing an epileptic seizure. In such cases, rimantadine is used at a dose of 0.1 g per day at the same time as anticonvulsant therapy. Prophylactic administration is effective in contact with the sick (taking the drug is necessary for at least 10 days after contact), with the infection spreading in closed collectives and at high risk the onset of the disease during a flu epidemic. During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration. attention and speed of psychomotor reactions.