Sanorin-xylo nasal drops 0.05% 10ml
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Active ingredients
Xylometazoline
Release form
Drops
Composition
1 ml of the preparation contains: active ingredient: Xylometazoline hydrochloride 1 mg; excipients: citric acid monohydrate, sodium citrate dihydrate, glycerol, water for injection
Pharmacological effect
Vasoconstrictor for local use in ENT practice. Alpha adrenomimetic. When applied to the mucous membranes causes vasoconstriction, as a result, local hyperemia and edema are reduced. When rhinitis facilitates nasal breathing.
Pharmacokinetics
When applied topically, it is practically not absorbed, plasma concentrations are so small that they cannot be determined by modern analytical methods.
Indications
Acute rhinitis, sinusitis, laryngitis, eustachitis, rhinoscopy, the need to stop nasal bleeding
Contraindications
Hypersensitivity to xylometazoline or other components of the drug; - dry rhinitis; - use after hypophysectomy or other surgical procedures carried out through the dura mater; - children's age up to 2 years. Sanorin-Xylo is used with caution in patients with hypertension, cardiovascular diseases, metabolic disorders (including hyperthyroidism, diabetes), increased intraocular pressure (especially in angle-closure glaucoma), feohromocytoma, porphyria, prostatic hyperplasia, taking monoamine oxidase inhibitors (MAO) and tricyclic antidepressants, as well as during pregnancy and lactation
Precautionary measures
For hygienic reasons and to avoid droplet infection, the drug should always be used by one patient only.
Use during pregnancy and lactation
The drug Sanorin-Xylo can be taken during pregnancy only after a thorough assessment of the balance of benefits and risks. Since an overdose can disrupt the blood supply to the fetus, during pregnancy you cannot exceed the recommended dose. During the period of breastfeeding, the drug Sanorin-Xylo should be taken with caution. Due to the possible reduction in milk production, the recommended dose should not be exceeded.
Dosage and administration
Intranasal. For children and adolescents aged 2-15 years, the recommended dose is 1-2 drops in each nostril 2-3 times a day. The interval between instillations must be at least 4 hours. To stop nasal bleeding, a cotton swab moistened with a 0.05% concentration of Sanorin solution is placed in the nasal passage. Nasal drops of 0.05% can be used as an additional agent in the treatment of conjunctivitis of bacterial origin. To this end, Sanorin is instilled 1-2 drops in each conjunctival sac 3-4 times a day. Before the first injection of the spray, it is recommended to press the dosing device several times until a compact aerosol cloud appears. Before use, it is necessary to remove the protective cap and, holding the bottle in a vertical position, insert the end part of the device into the nasal passage, then quickly and abruptly press the applicator. Immediately after the injection, inhale lightly with the nose and close the applicator with a protective cap.
Side effects
The frequency of side effects is classified according to the recommendations of the World Health Organization: very often - at least 10%; often not less than 1%, but less than 10%; infrequently - not less than 0.1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%. Immune system disorders: infrequently - hypersensitivity reaction, vascular edema, skin rash, itching. Violations of the central nervous system (CNS): very rarely - anxiety, insomnia, fatigue, lethargy, apathy, headache, dizziness, nausea, hallucinations (mainly in children). Violations of the cardiovascular system: rarely - a sensation of heartbeat, tachycardia, increased blood pressure; very rarely - arrhythmia. Disturbances in the respiratory system, organs of the chest and mediastinum: often - burning, dryness of the nasal mucosa, sneezing; infrequently, after a weakening of the therapeutic effect, increased swelling of the nasal mucosa, nosebleeds. Disorders of the musculoskeletal and connective tissues: very rarely - seizures (mainly in children). With an overdose of Sanorin-Xylo, feelings of fear, anxiety, hallucinations, convulsions, decreased body temperature, apathy, drowsiness, coma, miosis, mydriasis, increased sweating, fever, pallor, cyanosis, nausea, tachycardia, bradycardia, cardiac arrhythmia, cyanosis, nausea, tachycardia, bradycardia, cardiac arrhythmia, cyanosis, nausea, tachycardia, bradycardia, cardiac arrhythmia, cyanosis, nausea, tachycardia, bradycardia, cardiac arrhythmia, cyanosis, nausea, tachycardia, bradycardia, cardiac arrhythmia, cyanosis, nausea, tachycardia, bradycardia, cardiac arrhythmia, cardiac arrhythmia, may develop. and apnea, a sharp decrease in blood pressure, pulmonary edema, increased blood pressure, cardiac arrest. For the treatment of overdose, symptomatic therapy is prescribed; if the drug is accidentally taken orally, the administration of activated carbon, sodium sulfate (laxative), gastric lavage. In severe cases, non-selective alpha-blockers can be used to lower blood pressure, as well as intubation and mechanical ventilation. Vasoconstrictor drugs are contraindicated.
Overdose
Symptoms: fear, anxiety, hallucinations, convulsions, decreased body temperature, apathy, drowsiness, coma, miosis, mydriasis, increased sweating, fever, pallor, cyanosis, nausea, tachycardia, bradycardia, cardiac arrhythmia, respiratory failure and apnea, cramping blood pressure, pulmonary edema, increased blood pressure, cardiac arrest. Treatment: in overdose, symptomatic treatment is indicated under supervision. In severe cases, non-selective alpha-blockers can be used to reduce blood pressure, as well as intubation and mechanical ventilation. Vasoconstrictor drugs are contraindicated. If you accidentally take a moderate or large amount of the drug inside, you should take activated charcoal (adsorbent) and sodium sulfate (laxative), make a gastric lavage
Interaction with other drugs
Simultaneous use of tri- or tetracyclic antidepressants may increase the systemic effects of xylometazoline. At the same time taking Xylometazoline with MAO inhibitors, there may be a risk of high blood pressure.
special instructions
With prolonged use of Sanorin-Xylo may weaken the therapeutic effect, and also increases the risk of reactive hyperemia and atrophy of the nasal mucosa (medication rhinitis). There was no effect on the ability to manage vehicles and work with equipment. With the development of undesirable reactions from the central nervous system, caution should be exercised when performing actions that require increased concentration of attention and speed of psychomotor reactions.