Theraflu LAR Menthol lozenges 20pcs
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Active ingredients
Benzalkonium chloride
Release form
Pills
Composition
1 tab. cetylpyridinium chloride 2 mg lidocaine hydrochloride 1 mg. Auxiliary substances: oil of peppermint leaves of black-leaved - 0.
Pharmacological effect
Combined for topical use, it contains an antiseptic and a local anesthetic. Cetylpyridinium chloride, an antiseptic from the group of quaternary ammonium compounds, has bactericidal activity against gram-positive and to a lesser extent gram-negative bacteria. Changes the permeability of the cytoplasmic membrane of bacteria, violates the internal oxidative mechanisms of respiration of bacteria, which leads to their death. Cetylpyridinium chloride has antifungal and antiviral activity against enveloped viruses. Lidocaine hydrochloride is a local anesthetic from the group of amides, during inflammatory processes it relieves sore throat when swallowing. Lidocaine violates the permeability of the cell membrane for sodium ions, which leads to anesthesia as a result of the blockade of nerve impulses.
Pharmacokinetics
Cetylpyridinium chloride is practically not absorbed through the mucous membrane of the oral cavity. Lidocaine hydrochloride is poorly absorbed through the mucous membrane of the mouth. When ingestion is absorbed, being metabolized during the "first pass" through the liver. When taken orally, its bioavailability is about 35%. Metabolites are excreted in the urine, less than 10% of the substance excreted unchanged.
Indications
Infectious and inflammatory diseases of the mouth and throat: - pharyngitis - laryngitis - catarrhal tonsillitis - stomatitis - ulcerative gingivitis - tonsillitis (as an aid).
Contraindications
- I trimester of pregnancy - breastfeeding period - children under 6 years old - sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption - hypersensitivity to the components of the drug. With care: open wounds of the oral mucosa.
Use during pregnancy and lactation
The use of the drug Theraflu LAR Menthol is contraindicated in the first trimester of pregnancy, since the drug penetrates the placental barrier.Application in the II-III trimesters of pregnancy is possible under the supervision of a physician, if the expected benefit to the mother outweighs the potential risk to the fetus. The drug is excreted in breast milk, so it is not recommended for use during breastfeeding.
Dosage and administration
The tablet should be slowly absorbed in the mouth. The tablet should not be chewed or swallowed. Do not take Theraflu LAR Menthol while or just before a meal. Adults and children over 12 years old: 1 tab. every 1-2 hours for acute inflammation and severe pain. With a lighter condition - 1 tab. every 2-3 hours. Maximum daily dose - no more than 6 tab. Children from 6 to 12 years: 1 tab. every 3-4 hours as needed, the maximum daily dose is not more than 3 tab. Do not use Theraflu LAR Menthol pills for more than 5 days in a row. If symptoms persist or are accompanied by high fever, dizziness or vomiting, you should stop taking the drug and consult a doctor.
Side effects
Determination of the frequency of adverse reactions: very often (10%); often (1%, but ≤ 10%), infrequently (0.1%, but ≤1%), rarely (0.01%, but ≤0.1%), very rarely (≤0.01%). On the part of the digestive system: rarely - nausea; very rarely - diarrhea. On the part of the skin and subcutaneous tissues: very rarely - skin rash, itching. Local reactions: rarely - local irritation of the mucous membrane of the mouth and throat.
Overdose
Symptoms: in case of accidental use of the drug (as well as other ammonium compounds) in high doses, nausea and vomiting are possible. The lidocaine content in the preparation is insignificant and cannot cause serious symptoms of overdose. Treatment: immediately stop taking the drug; it is recommended to drink milk or eat egg whites whipped in water.
Interaction with other drugs
Interaction with other drugs Theraflu LAR Menthol was not detected.
special instructions
The drug should not be taken immediately before a meal and at the same time with milk. The simultaneous intake of the drug with milk and food can reduce the local antiseptic and anesthetic effects. Alcohol increases the absorption of cetylpyridinium chloride, so you should avoid drinking when taking the drug. Cetylpyridinium chloride inhibits wound healing.1 tablet of the drug contains 1107 mg of sorbitol as a sweetener, therefore Theraflu LAR Menthol should not be taken in patients with congenital fructose intolerance. Influence on ability to drive motor vehicles and control mechanisms It does not affect.