Tiberal 500mg N10 coated pills
Condition: New product
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Active ingredients
Ornidazole
Release form
Pills
Composition
Active ingredient: Ornidazole (ornidazole) Active ingredient concentration (mg): 500
Pharmacological effect
Anti-protozoan, a derivative of 5-nitroimidazole. It is believed that the mechanism of action is associated with a violation of the structure of DNA sensitive microorganisms. it is active against trichomonas vaginalis, giardia lamblia, entamoeba histolytica, as well as against some anaerobic bacteria (including bacteroides spp., clostridium spp., fusobacterium and anaerobic cocci). 1/2 of ornidazole is more than metronidase than metronidase.
Pharmacokinetics
After ingestion, absorption from the gastrointestinal tract is high. The time to reach Cmax is 1-2 hours. Plasma protein binding is 15% or more. Penetrates the BBB. T1 / 2 - about 13 hours. It is excreted in the form of metabolites by the kidneys (60-70%) and with feces (20-25%), in unchanged form - about 5%.
Indications
Trichomoniasis, amebiasis (intestinal and non-intestinal forms, including amoebic dysentery and amebic abscess of the liver), giardiasis, prevention of postoperative complications (especially during operations on the colon or in gynecology).
Contraindications
Hypersensitivity to the drug or other derivatives of nitroimidazole.
Precautionary measures
At the time of treatment lactating women should stop breastfeeding, I trimester of pregnancy.
Use during pregnancy and lactation
Contraindicated in the first trimester of pregnancy, during lactation. In pregnancy, use is possible only by absolute indications, if the expected benefit to the mother outweighs the potential risk to the fetus.
Dosage and administration
Tiberal is always taken after a meal. Trichomoniasis: 1 tablet 2 times a day (morning and evening) for 5 days. To eliminate the possibility of re-infection, the sexual partner in all cases should receive the same course of treatment. The daily dose for children is 25 mg / kg body weight and is assigned in one step.
Side effects
Mild drowsiness, headaches and gastrointestinal disturbances (nausea). In some cases - violations of the central nervous system, such as dizziness, tremor, rigidity, impaired coordination, convulsions, fatigue, temporary loss of consciousness, signs of sensory or mixed peripheral neuropathy. Cases of taste perversion, changes in liver function tests, skin reactions and hypersensitivity reactions were observed.
Interaction with other drugs
Potentiates the effect of indirect anticoagulants, increases the duration of the action of vecuronium bromide.
special instructions
Does not inhibit alcohol dehydrogenase, therefore it is not incompatible with alcohol.