Tizin xylo spray nasal 0.05% 10ml
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Active ingredients
Xylometazoline
Release form
Spray
Composition
Xylometazoline hydrochloride 0.5 mg 0.035 mg. Additional substances: benzalkonium chloride - 0.2 mg, sorbitol 70% - 20 mg, sodium chloride - 4.16 mg, sodium dihydrogen phosphate dihydrate - 3.38 mg, disodium hydrogen phosphate dihydrate - 2.08 mg, disodium edetate - 1 mg, 1 mg, water, 0.3 mg, 1 mg, water, etc. enough.
Pharmacological effect
Vasoconstrictor drug for local use in ENT practice. Xylometazoline (imidazole derivative) is an alpha adrenergic mimetic. It has a vasoconstrictor effect, reduces swelling of the nasal mucosa. The drug facilitates nasal breathing by reducing swelling and hyperemia of the mucous membrane, and also improves the discharge of secretions. The effect of the drug occurs in 5-10 minutes.
Pharmacokinetics
With topical administration, xylometazoline is practically not absorbed, its plasma concentrations are so small that it is impossible to determine them by modern analytical methods.
Indications
- to reduce swelling of the mucous membrane of the nasopharynx and secretions in acute allergic rhinitis, acute respiratory infections with rhinitis, sinusitis, pollinosis, otitis media; - preparing patients for diagnostic manipulations in the nasal passages.
Contraindications
- simultaneous use of MAO inhibitors or other drugs that increase blood pressure; - arterial hypertension; - tachycardia; - pronounced atherosclerosis; - glaucoma; - atrophic rhinitis; - surgery on the meninges (in history); - children under 6 years old (for spray nasal 0.1%; - children up to 2 years old (for a nasal spray 0.05%); - hypersensitivity to the components of the drug.With caution, you should prescribe the drug for IHD (angina), prostatic hyperplasia, thyrotoxicosis, diabetes, feoh omotsitome.
Precautionary measures
Use in children Spray nasal 0.1% is contraindicated in children under 6 years old, nasal spray 0.05% is contraindicated in children under 2 years.
Use during pregnancy and lactation
Xylometazoline should not be used during pregnancy, because The effects of this drug on the fetus have not been studied. It is not known whether Xylometazoline is derived from breast milk. Therefore, it is not recommended to prescribe the drug during breastfeeding.
Dosage and administration
Tizin Xylo in the form of a nasal spray 0.05% is prescribed to children aged 2 to 6 years, 1 dose in each nasal passage 1-2 times / day. each nasal course 3 times / day. The dose depends on the patient's individual sensitivity and clinical effect. The drug should not be used for more than 5-7 days without a doctor's recommendation. After completing the therapy, the drug can be reappointed only after a few days. .
Side effects
Local reactions: burning sensation, paresthesia, sneezing, hypersecretion, in some cases - reactive hyperemia; with frequent and / or long-term use or use in high doses - dry nasal mucosa, burning sensation, reactive stagnation with the development of medical rhinitis (this effect can be observed even 5-7 days after completion of treatment). With prolonged use, it is possible to develop dry rhinitis (irreversible damage to the nasal mucosa with the formation of crusts). From the nervous system: very rarely - headache, insomnia, increased fatigue, depression (with prolonged use in high doses). Systemic reactions: in isolated cases - heartbeat, tachycardia, arrhythmias, increased blood pressure, visual impairment.
Overdose
Symptoms: mydriasis, nausea, vomiting, cyanosis, fever, spasms, tachycardia, cardiac arrhythmia, collapse, cardiac arrest, hypertension, pulmonary edema, respiratory disorders, personality disorders, inhibition of CNS functions accompanied by drowsiness, decrease in body temperature, bradycardia, shock-like hypotonia , apnea, coma. Treatment: gastric lavage, the appointment of activated carbon, if necessary, artificial respiration with the introduction of oxygen. To reduce blood pressure - Phentolamine (dissolved in saline) IV slowly in a dose of 5 mg or orally in a dose of 100 mg. Vasopressor agents are contraindicated. If necessary, use antipyretic and anticonvulsant drugs.
Interaction with other drugs
With simultaneous use of the drug Tizin Ksilo and MAO inhibitors of the type of nilipromipin and tricyclic antidepressants may increase blood pressure.
special instructions
Prolonged use of the drug and overdose can lead to reactive hyperemia of the nasal mucosa. The recoil phenomenon can cause airway obstruction, which causes the patient to use the drug again or even constantly. This can lead to chronic edema (medical rhinitis), and sometimes even to atrophy of the nasal mucosa (ozen). In chronic rhinitis, use of the drug is possible only under medical supervision, given the risk of nasal atrophy. The drug should not be used in the presence of hypersensitivity to benzalkoniya chloride, which is part of the drug as a preservative. Effect on the ability to drive vehicles and control mechanisms During long-term treatment or when used in doses n recommended greater than the operation can not exclude the possibility of systemic effects on the cardiovascular system. In these cases, the ability to drive vehicles or equipment may be reduced.