Trombless gel 1000e for 30g
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Active ingredients
Sodium heparin
Release form
Gel
Composition
1 g of gel contains: heparin sodium 1000 ME. Excipients: ethanol (ethyl alcohol) - 240 mg methyl parahydroxybenzoate (Nipagin, methylparaben) - 1.2 mg propyl parahydroxybenzoate (Nipasol, propylparaben) - 300 mcg, diethanolamine (2,2-iminodiethanol) - up to 14 mg (for the gel pH from 7.5 to 8.7), carbomer (Carbopol) - up to 15 mg, water (purified water) - up to 1 g.
Pharmacological effect
Direct anticoagulant. It has anti-inflammatory, anti-proliferative, anti-edema and analgesic effects. Reduces platelet aggregation, binds to antithrombin III, preventing the transfer of prothrombin to thrombin. Inhibits thrombin activity. It reduces the activity of hyaluronidase, improves blood fibrinolytic properties. Trombless improves microcirculation and activates tissue metabolism, thereby accelerating the resorption of hematomas and blood clots, ultimately restores the patency of the veins, clinically it is accompanied by a pronounced anesthetic and anti-inflammatory effect.
Pharmacokinetics
A small amount of heparin is absorbed from the skin surface into the systemic circulation. Cmax of the active substance in the blood is noted 8 hours after application. Heparin is mainly excreted in the urine. T1 / 2 is 12 hours.
Indications
Migrating phlebitis (including chronic varicose veins and varicose ulcers); thrombophlebitis of the superficial veins; local edema and aseptic infiltrates; complications arising after surgical operations on the veins; subcutaneous hematomas (including after phlebectomy); injuries, bruises of joints, tendons, muscle tissue.
Contraindications
Ulcerative-necrotic, purulent processes on the skin; traumatic violation of the integrity of the skin; hypersensitivity to the drug.
Precautionary measures
With care: the increased tendency to bleeding, thrombocytopenia.
Use during pregnancy and lactation
Perhaps the use of the drug during pregnancy and lactation according to indications.
Dosage and administration
The drug should be used externally: 3-10 cm of the gel rubbing movements applied to the skin over the affected area 1-3 times / day. When thrombosis of hemorrhoidal veins use gaskets with gel applied.
Side effects
Local reactions: with prolonged use possible skin hyperemia, allergic reactions.
Overdose
Data on overdose of the drug Trombless is not provided.
Interaction with other drugs
Combined use of the drug with oral anticoagulants may cause an increase in prothrombin time.
special instructions
Trombless has no irritant effects.