Troxevasin Neo gel for external use 40 g
Condition: New product
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Active ingredients
Sodium Heparin + Dexpanthenol + Troxerutin
Release form
Gel
Composition
1 g of gel contains: heparin sodium 1.7 mg (300 IU); troxerutin 20 mg; dexpanthenol 50 mg. Excipients: carbomer - 7 mg, propylene glycol - 100 mg, methyl parahydroxybenzoate - 0.8 mg, propyl parahydroxybenzoate - 0.2 mg, trolamine - 4.2 mg, purified water - up to 1 g.
Pharmacological effect
Combined preparation for external use. The action is due to its constituent ingredients. Troxerutin is an angioprotective agent. It has P-vitamin activity: it has a venotonic, venoprotective, anti-edematous, anti-inflammatory, anti-clotting and antioxidant action. Reduces permeability and fragility of capillaries, increases their tone. Increases the density of the vascular wall. It promotes the normalization of microcirculation and trophism of tissues, reduces stagnation. Heparin is a direct acting anticoagulant, a natural anticoagulant factor of the body. It prevents blood clots, activates the fibrinolytic properties of blood, improves local blood flow. It has anti-inflammatory effect, contributes to the regeneration of connective tissue by inhibiting the activity of hyaluronidase. Dexpanthenol - provitamin B5 - in the skin turns into pantothenic acid, which is part of coenzyme A, which plays an important role in the processes of acetylation and oxidation. Improving metabolic processes, dexpanthenol promotes the regeneration of damaged tissues; improves heparin absorption.
Pharmacokinetics
When applied topically, the active substances are rapidly absorbed by the skin. Troxerutin is detected in the dermis after 30 minutes, and in the subcutaneous fat after 2-5 hours. The penetration of troxerutin into the systemic circulation is clinically insignificant. Heparin accumulates in the upper layers and is actively associated with skin proteins. When applied externally, a small amount of heparin penetrates into the systemic circulation, without a systemic effect, without causing any changes in blood coagulation parameters. Does not penetrate the placental barrier. Dexpanthenol penetrates all layers of the skin and turns into pantothenic acid, binds to plasma proteins (mainly beta-globulin and albumin).Pantothenic acid is not metabolized in the body and is excreted unchanged.
Indications
Varicose veins; chronic venous insufficiency with symptoms such as swelling and pain in the legs, feeling of heaviness, nausea, tired legs, spider veins and spider veins, convulsions, paresthesias; thrombophlebitis; periflebitis; varicose dermatitis; traumatic pain and swelling (bruises, sprains, injuries).
Contraindications
Open infected wounds or wounds with abundant exudation at the site of application; hypersensitivity to the drug; children and adolescents up to 18 years old (no experience).
Precautionary measures
Avoid contact with open wounds, mucous membranes and eyes!
Use during pregnancy and lactation
Troxevasin; Neo is approved for use during pregnancy and lactation (breastfeeding).
Dosage and administration
Apply externally. The gel is applied with a thin layer to the affected area 2 times a day, in the morning and in the evening, evenly spreading over the skin surface with light rubbing movements until completely absorbed. If necessary, the gel can be applied under bandages or elastic stockings. The success of drug treatment largely depends on its regular use for a long time. The course of treatment is 2-3 weeks. The need for a longer treatment is determined by the attending physician. A second course of treatment is recommended 2-3 times a year. It is recommended to combine with taking Troxevasin capsules; to enhance exposure.
Side effects
Allergic reactions: skin rash, itching (at the site of application of the drug).
Overdose
Overdose is unlikely due to low systemic absorption of the active components of the gel.
Interaction with other drugs
Drug interactions Troxevasin; Neo with other drugs have not been identified.
special instructions
Drug Troxevasin; Neo is not intended for use in ophthalmology, for intravaginal and rectal administration. The effect on the ability to drive vehicles and control mechanisms. Against the background of the drug intake, there was no negative effect on the ability to drive a car or other technical means.