Acyclovir Akrikhin ointment 5% 5g
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Active ingredients
Acyclovir
Release form
Ointment
Composition
Excipients: calcium hydrophosphate dihydrate - 186 mg, copovidone - 6 mg, carboxymethyl starch sodium - 4.5 mg, colloidal silicon dioxide - 1.5 mg, magnesium stearate - 2 mg. The composition of hard gelatin capsules: gelatin - 74.4572 mg, titanium dioxide - 0.76 mg, iron dye red oxide - 0.532 mg, iron dye black oxide - 0.152 mg, iron dye yellow oxide - 0.0988 mg
Pharmacological effect
Acyclovir is an antiviral drug, a synthetic analogue of the acyclic purine nucleoside, which has a highly selective effect on herpes viruses. Inside viral infected cells, viral thymidine kinase undergoes a series of consecutive transformations of acyclovir into mono-, di-, and acyclovir triphosphate. Acyclovir triphosphate is inserted into the viral DNA chain and blocks its synthesis through competitive inhibition of viral DNA polymerase. In vitro, acyclovir is active against Herpes simplex type 1 and 2, Varicella zoster; higher concentrations are required to inhibit Epstein-Barr virus. In vivo acyclovir is therapeutically and prophylactically effective primarily in viral infections caused by Herpes simplex.
Indications
treatment of infections of the skin and mucous membranes caused by Herpes simplex type 1 and 2, both primary and secondary, including genital herpes; prevention of exacerbations of recurrent infections caused by the Herpes simplex type 1 and 2 virus in patients with normal immune status; prevention of primary and recurrent infections caused by the Herpes simplex type 1 and 2 virus in immunocompromised patients; as part of complex therapy in patients with severe immunodeficiency: in HIV infection (AIDS stage, early clinical manifestations and developed clinical picture) and in patients undergoing bone marrow transplantation; treatment of primary and recurrent infections caused by the Varicella zoster virus (chickenpox, shingles).
Contraindications
Hypersensitivity to acyclovir and other components of the drug. With caution should use the drug for dehydration, renal failure, pregnancy, during lactation.
Use during pregnancy and lactation
The use of the drug is indicated only in cases where the intended benefit to the mother outweighs the potential risk to the fetus. During treatment, it is necessary to solve the issue of stopping breastfeeding.
Dosage and administration
Ointment Acyclovir is applied to the affected surface 5 times / day (after 4 hours).The duration of treatment is 5-10 days.
Side effects
On the part of the skin and subcutaneous tissues: hyperemia, dryness, peeling of the skin. Other: burning, inflammation in contact with mucous membranes. Perhaps the development of allergic dermatitis.
Overdose
Data on drug overdose is not provided.
Interaction with other drugs
When applied externally, no interaction with other drugs was detected. The increased effect is noted with the simultaneous appointment of immunostimulants.
special instructions
To achieve the maximum therapeutic effect, it is necessary to use the drug as early as possible (at the first signs of the disease: burning, itching, tingling, feeling of tension and redness). Ointment is not recommended to put on the mucous membranes of the mouth and eyes, because possible development of pronounced local inflammation. When treating genital herpes, you should avoid sex or use condoms, because use of acyclovir does not prevent transmission of the virus to partners.