Diclofenac eye drops 0.1% 5ml
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Description
Diclofenac eye drops have anti-inflammatory and analgesic effects.
Active ingredients
Diclofenac
Composition
1 ml contains diclofenac sodium 1 mg. Excipients: sodium chloride, propylene glycol, sodium dihydrogen phosphate dihydrate (sodium phosphate monosubstituted two-water), disodium hydrogen phosphate dodecahydrate (sodium phosphate disubstituted 12-water), disodium edetate, sodium hydroxide (0%, if you are in the form of a red line, disaggregated sodium phosphate disubstituted 12-water) and.
Pharmacological effect
NSAIDs, a derivative of phenylacetic acid, has anti-inflammatory and analgesic effects. Indiscriminately inhibiting COX-1 and COX-2, violates the metabolism of arachidonic acid, reduces the amount of prostaglandins in the focus of inflammation. When applied topically, it reduces swelling and pain in inflammatory processes of non-infectious etiology.
Pharmacokinetics
The time to reach Cmax in the cornea and conjunctiva is 30 minutes. After instillation, penetrates into the anterior chamber of the eye, in the systemic circulation in therapeutically significant concentrations is not detected.
Indications
Inhibition of miosis during cataract surgery, inflammatory processes after surgical interventions, prevention of cytoid edema of the optic nerve before and after surgery associated with the removal and implantation of the lens, inflammatory processes of non-infectious nature involving the anterior eye, and post-traumatic inflammation after penetrating and non-penetrating wounds of the eye apple pain syndrome during excimer laser intervention.
Contraindications
The third trimester of pregnancy, children's age (up to 2 years), hypersensitivity to NSAIDs and other components of the drug. With care: "aspirin" asthma, epithelial herpetic keratitis (including in history), diseases that cause blood clotting disorders (including hemophilia). Particular caution should be exercised to patients with gastric ulcer and duodenal ulcer in the acute stage, as well as in connection with the risk of bleeding in patients receiving anticoagulants, during pregnancy, lactation, children of childhood (older than 2 years), the elderly to patients.
Use during pregnancy and lactation
In pregnancy, the use of the drug is justified if the potential benefit to the mother outweighs the potential risk to the fetus. During the use of the drug, breastfeeding should be discontinued.
Dosage and administration
Locally. Instill into the conjunctival sac before the operation 1 drop 5 times for 3 hours with an interval of 20-25 minutes, immediately after the operation - 1 drop 3 times, then 1 drop 3-5 times / day for the required time, other indications - 1 drop 4-5 times / day.
Side effects
Local reactions: burning sensation in the eye, blurred vision (immediately after instillation), corneal clouding (eyesore), iritis. Allergic reactions: itchy eyes, conjunctival hyperemia, angioedema of the face, fever, chills, photosensitivity, skin rash (mainly erythematous), urticaria. On the part of the digestive system: nausea, vomiting.
Overdose
When using Diclofenac eye drops in recommended doses, overdose is unlikely.
Interaction with other drugs
The interval after application of Diclofenac eye drops and other eye drops must be at least 5 minutes. In the presence of clinical indications can be combined with eye drops containing glucocorticosteroids.
special instructions
Immediately after instillation, there may be blurred vision, which may lead to difficulty in managing vehicles, (including cars), and work at height. It is necessary to resume such activities only 15 minutes after the administration of the drug. It is not allowed to wear soft contact lenses simultaneously with the introduction of the drug. Hard contact lenses should be removed before instillation and re-installed only 20 minutes after the injection.