Diclofenac ointment 1% 30 g
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Diclofenac
Release form
Ointment
Composition
100 g diclofenac sodium 1 g.
Pharmacological effect
NSAID, a derivative of phenylacetic acid. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with inhibition of the activity of COX - the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Inhibits the synthesis of proteoglycan in cartilage. In rheumatic diseases it reduces joint pain at rest and during movement, as well as morning stiffness and swelling of the joints, and contributes to an increase in the range of motion. Reduces post-traumatic and postoperative pain, as well as inflammatory edema. Suppresses platelet aggregation. With prolonged use has a desensitizing effect. When applied topically in ophthalmology, it reduces swelling and pain in inflammatory processes of non-infectious etiology.
Indications
Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), degenerative and chronic inflammatory diseases of the musculoskeletal system (osteochondrosis, osteoarthritis, periarthropathy), post-traumatic inflammation of soft tissues and musculoskeletal system (elongation). Pain in the spine, neuralgia, myalgia, arthralgia, pain and inflammation after operations and injuries, pain in gout, migraine, algomenorrhea, pain in adnexitis, proctitis, colic (biliary and renal), pain in infectious and inflammatory diseases of the ENT -organs For local use: inhibition of miosis during cataract surgery, prevention of cystoid macular edema associated with the removal and implantation of the lens, inflammatory processes of the eye of non-infectious nature, post-traumatic inflammatory process with penetrating and non-penetrating injuries of the eyeball.
Contraindications
Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, aspirin triad, impaired blood formation of unknown etiology, hypersensitivity to diclofenac and components of the dosage form used, or other NSAIDs.
Use during pregnancy and lactation
Use during pregnancy and lactation is possible in cases where the intended benefit to the mother outweighs the potential risk to the fetus or newborn.
Dosage and administration
For oral administration for adults, a single dose is 25-50 mg 2-3 times / day. The frequency of administration depends on the used dosage form, the severity of the disease and is 1-3 times / day, rectally - 1 time / day. For the treatment of acute conditions or the relief of exacerbation of a chronic process, apply IM in a dose of 75 mg. For children over 6 years old and adolescents, the daily dose is 2 mg / kg. Outwardly used in a dose of 2-4 g (depending on the area of the painful area) at the affected site 3-4 times / day. When used in ophthalmology, the frequency and duration of administration are determined individually. The maximum daily intake for adults when administered orally is 150 mg / day.
Side effects
On the part of the digestive system: nausea, vomiting, anorexia, pain and discomfort in the epigastric region, flatulence, constipation, diarrhea. in some cases - erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract. rarely - abnormal liver function. When administered rectally in isolated cases, there was inflammation of the colon with bleeding, exacerbation of ulcerative colitis. From the side of the central nervous system and peripheral nervous system: dizziness, headache, agitation, insomnia, irritability, feeling of tiredness. rarely - paresthesia, visual impairment (vagueness, diplopia), tinnitus, sleep disorders, convulsions, irritability, tremor, mental disorders, depression. From the side of the blood system: rarely - anemia, leukopenia, thrombocytopenia, agranulocytosis. On the part of the urinary system: rarely - impaired renal function. in predisposed patients, edema is possible. Dermatological reactions: rarely - hair loss. Allergic reactions: skin rash, itching. when applied in the form of eye drops - itching, redness, photosensitivity.Local reactions: in the place of intramuscular injection, a burning sensation is possible, in some cases - the formation of infiltrate, abscess, necrosis of adipose tissue. with rectal administration, local irritation, the appearance of mucous secretions mixed with blood, painful defecation are possible. with external use in rare cases - itching, redness, rash, burning. with topical application in ophthalmology, transient burning sensation and / or temporary blurred vision are possible immediately after instillation. With prolonged external use and / or application to extensive body surfaces, systemic side effects are possible due to the resorptive action of diclofenac.
special instructions
On the part of the digestive system: nausea, vomiting, anorexia, pain and discomfort in the epigastric region, flatulence, constipation, diarrhea. in some cases - erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract. rarely - abnormal liver function. When administered rectally in isolated cases, there was inflammation of the colon with bleeding, exacerbation of ulcerative colitis. From the side of the central nervous system and peripheral nervous system: dizziness, headache, agitation, insomnia, irritability, feeling of tiredness. rarely - paresthesia, visual impairment (vagueness, diplopia), tinnitus, sleep disorders, convulsions, irritability, tremor, mental disorders, depression. From the side of the blood system: rarely - anemia, leukopenia, thrombocytopenia, agranulocytosis. On the part of the urinary system: rarely - impaired renal function. in predisposed patients, edema is possible. Dermatological reactions: rarely - hair loss. Allergic reactions: skin rash, itching. when applied in the form of eye drops - itching, redness, photosensitivity. Local reactions: in the place of intramuscular injection, a burning sensation is possible, in some cases - the formation of infiltrate, abscess, necrosis of adipose tissue. with rectal administration, local irritation, the appearance of mucous secretions mixed with blood, painful defecation are possible. with external use in rare cases - itching, redness, rash, burning. with topical application in ophthalmology, transient burning sensation and / or temporary blurred vision are possible immediately after instillation.With prolonged external use and / or application to extensive body surfaces, systemic side effects are possible due to the resorptive action of diclofenac.