Epigen intim spray for local and external use 60 ml
Condition: New product
997 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Ammonium Glycyrrhizinate
Release form
Spray
Composition
Active ingredient: Glycyrrhizinic acid (Glycyrrhizinic acid) Active ingredient concentration (mg): 1
Pharmacological effect
Antiviral agent for external and local use. Glycyrrhizic acid is active against DNA and RNA viruses, including various strains of the virus Herpes simplex, Varicella zoster, human papilloma virus, cytomegalovirus. The antiviral effect is apparently due to the induction of the formation of interferon. Interrupts the replication of viruses in the early stages, causes the release of the virion from the capsid, thereby preventing its penetration into the cells. This is due to selective dose-dependent inhibition of phosphorylating kinase P. It interacts with viral structures, changing various phases of the viral cycle, which is accompanied by irreversible inactivation of viral particles (in a free state outside the cells), blocking the introduction of active viral particles through the cell membrane into the cell, as well as impaired ability viruses to synthesize new structural components. Inhibits viruses in concentrations that are non-toxic to normally functioning cells. s resistant to acyclovir and yodouridinu, highly sensitive to glycyrrhizic kislote.Okazyvaet as antiinflammatory, analgesic and improving tissue regeneration effect as in the early manifestations of viral infection, and ulcerative forms.
Pharmacokinetics
When applied topically and locally, activated glycyrrhizic acid is deposited in the lesions. Systemic absorption is slow. The drug is found in the blood in trace amounts.
Indications
Treatment of genital infections caused by the Herpes simplex type 2 virus (both in acute primary and in relapsing course); treatment of skin infections caused by the virus Varicella zoster (as part of combination therapy); treatment of infections of the skin and mucous membranes caused by the human papilloma virus; treatment of nonspecific vaginitis, colpitis. Prevention of common sexually transmitted viral infections.
Contraindications
Hypersensitivity to glycyrrhizic acid.
Precautionary measures
During the period of treatment, it is not recommended to use interferon synthesis inducers. If signs of irritation of the skin or mucous membranes appear, treatment should be stopped.
Use during pregnancy and lactation
Application during pregnancy and lactation is possible according to absolute indications. In experimental studies, the embryotoxic and teratogenic action of glycyrrhizic acid has not been established.
Dosage and administration
Outer, intravaginal, intraurethral. Shake the can before use. At application to hold a cylinder in vertical position. When applied externally, the drug is applied to the entire affected skin surface from a distance of 4–5 cm 1–2 by pressing the valve, which is the optimal therapeutic dose. For intravaginal use of the drug, a special spray nozzle is attached. Remove the valve from the spray bottle and put on the nozzle valve. Then the nozzle is inserted into the vagina and injected by 1-2 presses of the nozzle, which is the optimal therapeutic dose. When used by men, in addition to external application, the drug is injected into the external opening of the urethra by 1-2 strokes of the spray valve.
Side effects
Allergic reactions.
Overdose
Data on overdose of Epigen is not.
Interaction with other drugs
With simultaneous use of glycyrrhizic acid with other antiviral drugs (acyclovir, iodouridine, interferon), potentiation of antiviral action is noted.
special instructions
When treating skin infections caused by the Varicella zoster virus, external use of glycyrrhizic acid should be combined with the ingestion of specific antiviral drugs.