Lomexin Capsules Vaginal 0.6mg N2
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Active ingredients
Fenticonazole
Release form
Capsules
Composition
1 vaginal capsule contains: Active substance: fenticonazole nitrate 600 mg. Adjuvants: soy lecithin, liquid paraffin, petrolatum. The composition of the capsule shell: glycerol, gelatin, propyl parahydroxybenzoate sodium, titanium dioxide, ethyl parahydroxybenzoate sodium.
Pharmacological effect
Antifungal broad-spectrum drug for local use in gynecology. Fenticonazole is a synthetic derivative of imidazole (its racemic mixture in the form of the nitric acid salt of fenticonazole). It has a local fungicidal and fungistatic effect. It also has antibacterial and anti-inflammatory effects. The mechanism of action is to inhibit the synthesis of ergosterol, which regulates the permeability of the cell membrane of fungi. It is active against the yeast fungi Candida spp. (including Candida albicans) and gram-positive bacteria (Staphylococcus aureus, Streptococcus spp.), as well as against Trichomonas vaginalis. Fenticonazole inhibits the biosynthesis of Candida sase proteases unlike other known azole compounds (in particular, econazole, miconazole and ketoconazole). at concentrations below the IPC - from 0.25 to 16 μg / ml. This action does not depend on the amount of antimycotic activity and is due to the inhibition of one of the stages of the formation of proteolytic enzymes by yeast-like fungi.
Pharmacokinetics
Fenticonazole is practically not subjected to systemic absorption, with prolonged vaginal use, its concentration in the blood is not determined. The degree of absorption into the mucous membrane is extremely small.
Indications
Vulvovaginal candidiasis, vaginal trichomoniasis.
Contraindications
Hypersensitivity to the drug, pregnancy, lactation, children's age. The drug should not be prescribed during menstruation.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
Currently, data on the efficacy and safety of Lomexin during pregnancy and lactation (breastfeeding) is not enough, so the appointment of the drug during these periods is not recommended.
Dosage and administration
One capsule (600 mg or 1000 mg) is inserted deep into the vagina in the supine position before bedtime once.If necessary, re-use after 3 days. When treating infections caused by Trichomonas vaginalis, it is possible to re-use the capsule (600 mg or 1000 mg) after 24 hours. In case of insufficient effectiveness, it is possible to repeat the course after 10 days.
Side effects
Allergic reactions: urticaria, rash, erythema. Local reactions: burning, itching, irritation at the site of the drug. Lomexin is generally well tolerated, side effects are transient in nature and do not require discontinuation of the drug.
Overdose
Due to the low degree of absorption into the systemic circulation, overdose is unlikely.
Interaction with other drugs
Drug interaction of the drug Lomexin with other drugs was not detected.
special instructions
With prolonged use of the drug may develop sensitization. In this case, it is necessary to stop treatment, and the patient should contact your doctor. In the absence of an effect within 3 weeks of therapy, treatment should be stopped and the diagnosis clarified. It is advisable to start the course of treatment after menstruation. on the glans penis and the foreskin. The effect on the ability to drive vehicles and control mechanisms There is no data on the negative impact of the drug on the cn lities to drive a car and other vehicles.