Loperamide-Akrikhin capsules2mg N10,
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Active ingredients
Loperamide
Composition
Loperamide hydrochloride 2 mg. Excipients: lactose monohydrate - 104.5 mg, corn starch - 30 mg, colloidal silicon dioxide - 0.7 mg, talc - 1.4 mg, magnesium stearate - 1.4 mg. The composition of the capsule shell: the hard gelatin capsule (titanium dioxide - 1.3333%, the quinoline yellow dye - 0.9197%, the sunset sunset sunflower yellow - 0.0044%, gelatin - up to 100%) - 38 mg.
Pharmacological effect
Loperamide, binding to the opioid receptors of the intestinal wall (stimulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of the smooth muscles of the intestine (by inhibiting the release of acetylcholine and prostaglandins). Slows peristalsis and increases the time of passage of intestinal contents. Increases the tone of the anal sphincter, helps to keep fecal masses and reduce the urge to defecate. The action develops quickly and lasts 4-6 hours.
Indications
Symptomatic treatment of acute and chronic diarrhea of various origins (allergic, emotional, medicinal, radiation, when changing the diet and the qualitative composition of food, in violation of metabolism and absorption, as an adjunct in infectious disease diarrhea). Regulation of stools in patients with ileostomy.
Contraindications
Hypersensitivity, intestinal obstruction, acute ulcerative colitis, diverticulosis, diarrhea on the background of acute pseudomembranous enterocolitis, dysentery and other infections of the gastrointestinal tract. Pregnancy (1 trimester), lactation period, children under 2 years of age (Loperamide-Akrikhin capsules are not indicated for children under 6 years of age).
Use during pregnancy and lactation
The drug is contraindicated in the first trimester of pregnancy, and during lactation.
Dosage and administration
Inside, without chewing, drink water. For adults with acute diarrhea, 2 capsules (4 mg) of Loperamide-Akrikhin are initially prescribed, then 1 capsule (2 mg) after each defecation event in the case of liquid stool. The highest daily dose is 8 capsules (16 mg). In chronic diarrhea, adults are prescribed 4 mg / day. The maximum daily dose is 16 mg. In acute diarrhea, children over 6 years old are prescribed in an initial dose of 2 mg, then 2 mg each after each bowel movement in the case of loose stools. The maximum daily dose is 4 capsules (8 mg).In chronic diarrhea, children over 6 years of age are prescribed Loperamide-Akrikhin in a daily dose of 2 mg. The maximum daily dose of 6 mg per 20 kg. After stool normalization or in the absence of stool for more than 12 hours, the drug should be stopped.
Side effects
It is observed, as a rule, only with long-term use of the drug. Allergic reactions (skin rash), drowsiness, dizziness, hypovolemia, electrolyte disturbances, dry mouth, intestinal colic, gastralgia, pain or discomfort in the implant, nausea, vomiting, flatulence. Rarely - urinary retention, extremely rare - intestinal obstruction.
special instructions
It is observed, as a rule, only with long-term use of the drug. Allergic reactions (skin rash), drowsiness, dizziness, hypovolemia, electrolyte disturbances, dry mouth, intestinal colic, gastralgia, pain or discomfort in the implant, nausea, vomiting, flatulence are possible. Rarely - urinary retention, extremely rare - intestinal obstruction.