More info
Active ingredients
Metronidazole
Release form
Gel
Composition
Metronidazole 10 mg. Auxiliary substances: methyl parahydroxybenzoate, propyl parahydroxybenzoate, carbomer 940, disodium edetate, sodium hydroxide, propylene glycol, purified water.
Pharmacological effect
Metronidazole is a synthetic broad spectrum antimicrobial and antiprotozoal agent from the imidazole group. It is active against anaerobes (Bacteroides spp., Fusobacterium spp., Mobiluncus C, C, C, N, C, C, C, C, C, C, C, T, Peptostreptococcus Spp. Cp., Cp., Eubacterium spp., Bacteroides fragilis, Prevotella Spp., C, I, C, C, C, C, C, N, C, C, C, N, C). histolytica). When applied topically, it has an anti-acne effect, the mechanism of which is unknown (not related to the effect on the mite Demodex folliculorum found in hair follicles and sebaceous gland secretion, and any influence on the production of this secret). , has antioxidant activity. It is established that it significantly reduces the production of active oxygen by neutrophils, hydroxyl radicals and hydrogen peroxide, which are potential oxidants that can cause tissue damage at the site of inflammation. Metronidazole for external use is not effective against telangiectasia, marked with pink acne.
Pharmacokinetics
Absorption is minimal, after external application of the gel in the serum only trace amounts of the drug are detected. The absorbed metronidazole passes through the placenta and the blood-brain barrier. Cmax in the blood - up to 66 ng / ml (when applying 1 g of gel, equivalent to 7.5 mg of metronidazole).
Indications
- rosacea (including post steroids); - acne vulgaris; - oily seborrhea, seborrheic dermatitis; - trophic ulcers of the lower extremities (against a background of varicose veins, diabetes mellitus); cracked anus.
Contraindications
- hypersensitivity to the drug.
Use during pregnancy and lactation
With care - I trimester of pregnancy, lactation.
Dosage and administration
For external use. The gel is applied on a pre-cleaned affected skin with a thin layer 2 times / day, morning and evening, for 3-9 weeks. The duration of treatment is 3-4 months, the therapeutic effect is usually observed after 3 weeks of treatment.
Side effects
With topical application of the gel, the concentration of metronidazole in the blood is very low, so the risk of systemic side effects is low. Allergic reactions (urticaria, skin rash) can occur rarely; hyperemia, peeling, mild dryness and burning of the skin, tearing (if the gel is applied close to the eyes).
Overdose
Cases of drug overdose at recommended doses for external use of the drug was not observed.
Interaction with other drugs
When the topical application of the gel interaction with other drugs is negligible, however, caution should be exercised, while the appointment with warfarin and other indirect anticoagulants (increases the prothrombin time).
special instructions
Avoid contact with eyes. If the gel gets into your eyes, immediately rinse them with plenty of water.