Papazol Pharmstandard pills N10
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Active ingredients
Bendazole + Papaverine
Release form
Pills
Composition
Papaverine hydrochloride 30 mg bendazole hydrochloride 30 mg
Pharmacological effect
The combined drug has antispasmodic, hypotensive, vasodilating action. Bendazole is an antispasmodic myotropic action; has a hypotensive, vasodilating effect, stimulates the function of the spinal cord, has a moderate immunostimulating activity. Papaverin is an antispasmodic, has a hypotensive effect. Inhibits phosphodiesterase, causes accumulation of cAMP in the cell and a decrease in calcium content, reduces the tone and relaxes smooth muscles of internal organs (GIT, respiratory and urinary system) and blood vessels. In large doses, reduces the excitability of the heart muscle and slows intracardiac conduction. The effect on the central nervous system is weakly expressed (in large doses it has a sedative effect).
Indications
- arterial hypertension (labile); - spasm of peripheral arteries and cerebral vessels; - spasm of smooth muscles of internal organs (including gastric ulcer and duodenal ulcer, pyloric spasm, intestinal colic, cholecystitis, spastic colitis); residual effects); - peripheral facial nerve palsy.
Contraindications
- AV-conduction disorders; - Epileptic syndrome; - Broncho-obstructive syndrome; - Children up to 1 year; - Hypersensitivity to the components of the drug. With caution prescribed for reduced intestinal motility, traumatic brain injury, hepatic and / or renal failure, hypothyroidism, adrenal insufficiency, prostatic hyperplasia, during pregnancy and lactation.
Precautionary measures
During treatment, psoriasis may worsen. During pheochromocytoma, propranolol can only be used after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. during anesthesia, you must stop taking propranolol or find a remedy for anesthesia with minimal negative inotropic effects.The impact on the ability to drive vehicles and control mechanisms of patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient.
Use during pregnancy and lactation
Be wary appointed during pregnancy and lactation.
Dosage and administration
Inside adults - 1-2 tab. 2-3 times / day.
Side effects
On the part of the digestive system: nausea, constipation. On the side of the central nervous system: dizziness. On the part of the cardiovascular system: AV blockade, arrhythmias, decreased myocardial contractility. Others: allergic reactions, increased sweating.
Interaction with other drugs
With simultaneous use of the drug with antispasmodics, sedative drugs, diuretics, tricyclic antidepressants, procainamide, reserpine, quinidine, the intensity of the hypotensive effect can be increased. funds reduce the absorption of the drug in the digestive tract.
special instructions
The safety of the drug during pregnancy and lactation has not been established.