Phlebodia 600 coated pills 600mg N60
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Active ingredients
Diosmin
Release form
Pills
Composition
1 tablet contains: Active substance: diosmin in terms of dry substance 600 mg. Adjuvants: talc - 10.24 mg, colloidal silicon dioxide - 3.5 mg, stearic acid - 50.05 mg, microcrystalline cellulose - up to 910 mg. Film coating composition: Sepyphilm 002 (hypromellose (E 464) - 9.832 mg, microcrystalline cellulose - 7.866 mg, macrogol 8 type 1 stearate - 1.967 mg); Sep 55 AP pink pink (propylene glycol - traces, hypromellose (E 464) - 0.458 mg, titanium dioxide (E 171) - 4.026 mg, crimson dye [Ponso 4R] (E 124) - 0.401 mg, ferric oxide black (E 172) - 0.13 mg, iron oxide red (E 172) - 0.02 mg); Opaglos 6000 (carnauba wax (E 903) - 0.075 mg, beeswax (E 901) - 0.075 mg, shellac (E 904) - 0.15 mg, ethanol 95 ° - traces).
Pharmacological effect
The drug has a phlebotonizing effect (reduces vein distensibility, increases venous tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of lymph capillary contractions, increases their functional density, decreases lymphatic pressure), improves microcirculation (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration into para-venous tissues, improves oxygen diffusion and perfusion in skin tissue, has anti-inflammatory action. Strengthens the vasoconstrictor action of adrenaline, noradrenalia, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
Pharmacokinetics
Rapidly absorbed from the gastrointestinal tract, detected in the plasma after 2 h after administration. Cmax in plasma is reached 5 h after administration. It is evenly distributed and accumulated in all layers of the wall of the hollow veins and subcutaneous veins of the lower extremities, to a lesser extent in the kidneys, liver and lungs and other tissues. The selective accumulation of diosmin and / or its metabolites in the venous vessels reaches its maximum by 9 o'clock after administration and remains within 96 hours. Excreted by the kidneys - 79%, by the intestines - 11%, with bile - 2.4%.
Indications
As part of complex therapy: - To eliminate the symptoms of lymphovenous insufficiency of the lower extremities: feeling of heaviness or tiredness in the legs, pain; - Additional treatment for microcirculation disorders; - Symptomatic therapy of acute hemorrhoids.
Contraindications
- Hypersensitivity to the components of the drug; - Breastfeeding period; - Children's age up to 18 years; - Pregnancy (I term) (experience of use is limited).
Use during pregnancy and lactation
Until now, in clinical practice, there have been no reports of any side effects when using the drug in pregnant women. Use during pregnancy in the II and III trimesters is possible only by prescription of the doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus. In experimental studies, no teratogenic effects on the fetus have been identified. During breastfeeding is not recommended taking the drug, because no data on the penetration of the drug into breast milk.
Dosage and administration
Before using the drug should consult a doctor. The drug is intended for oral administration. In case of varicose veins of the lower extremities and chronic lymphatic insufficiency (edema, pain, convulsions), it is prescribed 1 tablet per day. in the morning on an empty stomach. The duration of therapy is usually 2 months. When exacerbation of hemorrhoids, the drug is prescribed for 2-3 tab. / Day. with meals for 7 days. If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and in the usual dose.
Side effects
In rare cases, the hypersensitivity to the components of the drug, which requires a break in treatment: on the part of the gastrointestinal tract - dyspeptic disorders (heartburn, nausea, abdominal pain), on the part of the central nervous system - headache. any other side effects that are not listed in the instructions, inform your doctor.
Overdose
Symptoms of overdose are not described.
Interaction with other drugs
Clinically significant effects of interaction with other drugs are not described.
special instructions
Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct additional examinations and adjust the therapy being conducted. Effect on the ability to drive vehicles and control mechanisms