Picamilon pills 20 mg 30 pcs
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Active ingredients
Nicotinoyl gamma-aminobutyric acid
Release form
Pills
Composition
N-nicotinoyl-gamma-aminobutyric acid sodium salt 20 mg.
Pharmacological effect
Nootropic agent, dilates the blood vessels of the brain. It also has a tranquilizing, psychostimulant, antiplatelet and antioxidant effects. Improves the functional state of the brain due to the normalization of tissue metabolism and effects on cerebral circulation (increases the volumetric and linear speed of cerebral blood flow, reduces the resistance of cerebral vessels, suppresses platelet aggregation, improves microcirculation). memory, normalizes sleep; helps to reduce or eliminate feelings of anxiety, tension, fear; improves the condition of patients with motor and speech disorders.
Pharmacokinetics
Absorption is fast and complete, regardless of the route of administration. It penetrates the BBB and is retained for a long time in the tissues of the body. Bioavailability - 50-88%. Excreted mainly by the kidneys in unchanged form. T1 / 2 - 0.51 hour
Indications
Cerebrovascular insufficiency, asthenia, depressive disorders in the elderly. Conditions accompanied by anxiety, fear, increased irritability, emotional lability. Asthenic conditions caused by various neuropsychiatric diseases. As part of complex treatment - for stopping acute alcohol intoxication; in chronic alcoholism - to reduce asthenic, asthenoneurotic, postpsychotic, pre-relapse states, and alcoholic encephalopathy. As part of complex therapy, migraine (prophylaxis), TBI, neuroinfection. ; to restore the physical performance of athletes, to increase resistance to physical and mental stress). Open-angle glaucoma (to stabilize tionary function) .In urological practice (in children older than 3 years of age and in adults with urinary disorders) to improve the adaptation of the bladder (detrusor hypoxia reduction).
Contraindications
Chronic renal failure, pregnancy, lactation, hypersensitivity to nicotinoyl gamma-aminobutyric acid.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
Contraindicated use during pregnancy, during lactation (breastfeeding).
Dosage and administration
Is taken orally, regardless of the meal. For cerebrovascular diseases a single dose - 20-50 mg 2-3 times / day, daily dose - 60-150 mg. The course of treatment is 1-2 months. A repeated course - in 5-6 months. Depressive states of late age: 40-200 mg / day in 2-3 doses, the optimal dose range is 60-120 mg / day for 1.5-3 months. As an antiastenic and anxiolytic agent - 40-80 mg / day, if necessary, up to 200-300 mg / day, for 1-1.5 months. In alcoholism during withdrawal, a dose of 100-150 mg / day is prescribed, in a short course. 6-7 days; with more persistent violations outside the abstinence - 40-60 mg / day for 4-5 weeks. For recovery and with increased loads - 60-80 mg / day for 1-1.5 months, for athletes in the same dose, for 2 weeks training period. Parenterally administered into / in drip or jet (slowly), in / m. In chronic cerebral circulation disorders - in / in or in / m, 100-200 mg, 1-2 times / day, daily dose - 20 -40 mg. Depending on the patient's condition, they are used in the morning in / in the drip, in the evening - in / m; or within 10 days in / in, then in / m. The course of treatment is 15-30 days. In order to relieve acute uncomplicated ethanol intoxication, the complex therapy is administered in a saturating dose of 5 mg / kg and maintenance - 1.56 mg / kg / h in a volume of 2.5 l of infusion solution, for 4 hours, in the morning and evening In asthenic conditions, depending on the severity of the disease, in addition to oral administration, it is administered in a daily dosage of 20-40 mg for 1 month.
Side effects
Nausea, headache, dizziness, irritability, agitation, anxiety, allergic reactions (rash, itching).
Overdose
No data.
Interaction with other drugs
Reduces the duration of the action of barbiturates. Amplifies the effect of narcotic analgesics.
special instructions
No data.