Selectra pills 10 mg 56 pcs
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Active ingredients
Escitalopram
Release form
Pills
Composition
Escitalopram oxalate 12.78 mg, which corresponds to the content of escitalopram 10 mg Excipients: prosolv SMCC .90 / HD90 - 147.42 mg (microcrystalline cellulose - 144.47 mg Silicon dioxide - 2.95 mg), sodium croscarmellose - 9 mg Talc - 9 mg Magnesium stearate - 1.8 mg. The composition of the film shell: opadry white (Opadry 03F28446 White) - about 5.4 mg (hypromellose 6cP - 3.29 mg, titanium dioxide - 1.31 mg, macrogol 6000 - 0.8 mg).
Pharmacological effect
Antidepressant. selectively inhibits serotonin reuptake. increases the concentration of neurotransmitter in the synaptic cleft, strengthens and prolongs the action of serotonin on postsynaptic receptors. escitalopram practically does not bind to serotonin (5-ht), dopamine (d1 and d2) receptors, & # 945. -adreno, m-cholinergic receptors, and also with benzodiazepine and opioid receptors. antidepressant effect usually develops after 2-4 weeks. after starting treatment. The maximum therapeutic effect of treating panic disorders is reached approximately 3 months after the start of treatment.
Indications
panic states with or without agoraphobia. frustration depressive nature of any level of severity.
Contraindications
breast-feeding . hypersensitivity. age up to 15 years. parallel use with MAO inhibitors. pregnancy. Relative: kidney failure, with CC less than 30 ml / min. age of 15-18 years. manic disorders. hypomania. uncontrolled epilepsy. diabetes . suicidal depression. elderly age . predisposition to bleedings. cirrhosis of the liver . combined use with ethanol. drugs that cause hyponatremia. reduce convulsive readiness. metabolized by cytochrome CYP2C19
Use during pregnancy and lactation
Contraindicated use during pregnancy and lactation (breastfeeding).
Dosage and administration
Instructions for use Selectra recommends a single daily oral (internal) administration of pills to patients who have reached the age of 15 years. Panic states For the first 7 days of therapy, a daily dose of 5 mg is recommended, with a further increase to 10 mg.Consistent with the individual sensitivity of the patient to escitalopram, you can increase the daily dose to a maximum of 20 mg. Therapy is long, the maximum effectiveness of treatment is observed, as a rule, after 3 months. Depressive states. As a rule, 10 mg of Selectra is administered once per 24 hours. Consistent with the individual sensitivity of the patient to escitalopram, you can increase the daily dose to a maximum of 20 mg. Antidepressant efficacy in most cases develops over the 2nd — 4th week. In order to consolidate the positive effect, after leveling the symptoms of depression, it is necessary to continue treatment for another 6 months. Age after 65 years The recommended daily and maximum doses should be reduced by half. Pathology of the kidney When QA is more than 30 ml / min, there is no need to adjust the dosages of the Selectra. In the opposite case, use minimal doses of escitalopram, with their gradual increase according to the individual response of the patient. Pathology of the liver. The initial daily dosage of the Selectra is 5 mg. Consistent with the individual sensitivity of the patient to escitalopram, you can increase the daily dose to a maximum of 10 mg. Reduced CYP2C19 cytochrome activity Patients with insufficient CYP2C19 activity, for 14 days, require an initial daily dose of 5 mg. Consistent with the individual sensitivity of the patient to escitalopram, you can increase the daily dose to a maximum of 10 mg.
Side effects
Most often, side effects were observed during the first 14 days of therapy, after which their activity and frequency of manifestation decreased or completely stopped. CNS: depersonalization. dizziness . panic attacks . weakness anxiety insomnia irritability. sleepiness agitation. convulsions. visual impairment. tremor confusion movement disorders. hallucinations. serotonin syndrome (myoclonus, hyperthermia, tremor, agitation). manic disorders. Gastrointestinal tract: dryness in the oral cavity. diarrhea nausea taste disorders. vomiting. loss of appetite. constipation. Endocrine system: galactorrhea. decrease in secretion of ADH. Cardiovascular system: orthostatic hypotension. Genitourinary system: anorgasmia (in women). low libido. violation of ejaculation. urine retention. impotence.Skin: ecchymosis. rash. purpura. itchiness angioedema. Laboratory indicators: changes in hepatic function. hyponatremia. Allergic reactions: anaphylactic manifestations. Other: hyperthermia. excessive sweating. sinusitis. myalgia. arthralgia. withdrawal syndrome (with sudden discontinuation of treatment).
special instructions
Most often, side effects were observed during the first 14 days of therapy, after which their activity and frequency of manifestation decreased or completely stopped. CNS: depersonalization. dizziness . panic attacks . weakness anxiety insomnia irritability. sleepiness agitation. convulsions. visual impairment. tremor confusion movement disorders. hallucinations. serotonin syndrome (myoclonus, hyperthermia, tremor, agitation). manic disorders. Gastrointestinal tract: dryness in the oral cavity. diarrhea nausea taste disorders. vomiting. loss of appetite. constipation. Endocrine system: galactorrhea. decrease in secretion of ADH. Cardiovascular system: orthostatic hypotension. Genitourinary system: anorgasmia (in women). low libido. violation of ejaculation. urine retention. impotence. Skin: ecchymosis. rash. purpura. itchiness angioedema. Laboratory indicators: changes in hepatic function. hyponatremia. Allergic reactions: anaphylactic manifestations. Other: hyperthermia. excessive sweating. sinusitis. myalgia. arthralgia. withdrawal syndrome (with sudden discontinuation of treatment).