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Description
Teturam pills are used as a treatment for alcohol dependence.
Active ingredients
Disulfiram
Release form
Pills
Composition
1 tablet contains: teturam 150 mg. Excipients: potato starch, stearic acid, aerosil.
Pharmacological effect
Teturam inhibits acetaldehyde dehydrogenase, which is involved in ethanol metabolism, increases the concentration of acetaldehyde, which is a metabolite of ethanol and causes a number of unpleasant sensations after it is consumed (flushes of blood to the skin of the face, nausea, vomiting, malaise, tachycardia, a decrease in blood pressure).
Indications
Treatment and prevention of recurrence of chronic alcoholism, as a detoxification agent for chronic nickel poisoning.
Contraindications
Absolute: severe diseases of the cardiovascular system, organ of hearing (neuritis of the auditory nerve), organ of sight (glaucoma, optic neuritis), bronchial asthma, pulmonary emphysema, pulmonary tuberculosis, severe hepatic insufficiency, diseases of the blood-forming organs, diabetes mellitus, thyrotoxicosis, epilepsy , convulsive syndrome of any genesis, mental illness, exacerbation of peptic ulcer, kidney disease, malignant tumors, polyneuritis of any etiology, pregnancy, increased individual sensitivity to prepa ratu Relative: cardiovascular diseases in the compensation stage, old age (over 60 years), peptic ulcer and 12 duodenal ulcers in remission, residual effects after AMC, previously transferred teturamic (antabus) psychosis.
Use during pregnancy and lactation
Contraindicated during pregnancy and lactation.
Dosage and administration
Treatment is prescribed after a thorough examination of the patient and warning about the consequences and complications. The drug is taken orally on 150-500 mg 2 times a day for an individual scheme. After 7-10 days, a teturamalcohol sample is taken (20-30 ml of 40% vodka after taking 500 mg of the drug), with a weak reaction, the dose of alcohol is increased by 10-20 ml (the maximum dose of vodka is 100-120 ml). The sample is repeated after 1-2 days in the hospital and after 3-5 days on an outpatient basis, with the correction of doses of alcohol and / or the drug as needed.In the future, you can use a maintenance dose of 150-200 mg per day for 1-3 years.
Side effects
During the period of treatment with Teturam, a bitter taste in the oral cavity, headache, dizziness, memory disorder, insomnia, anxiety may appear. The most common side effects of Teturam are allergic reactions - urticaria, skin rash, angioedema, bronchospasm, dermatitis. When Teturam pills are implanted, rejection may occur, manifesting in the form of collapse, arrhythmia, brain edema, suppuration, heart attack.
Overdose
Symptoms: the teturam-ethanol combination can cause depression of consciousness, even coma, cardiovascular collapse, neurological complications. Treatment: symptomatic.
Interaction with other drugs
Contraindications combinations. Alcohol: intolerance reaction (flushing, erythema, vomiting, tachycardia). Avoid alcohol and drugs containing alcohol. Unwanted combinations. Isoniazid: impaired behavior and coordination. Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole): delirious disorders, confusion. Phenytoin: a significant and rapid rise in the level of phenytoin in plasma with toxic symptoms (suppression of its metabolism). If combinations cannot be avoided, clinical observation and control of drug concentrations in the plasma of the entry and after treatment with teturam should be carried out. Combinations that require caution. Warfarin (and other oral anticoagulants): an increased effect of oral anticoagulants and the risk of bleeding (reduction of warfarin in the liver). More frequent monitoring of warfarin concentration and adjusting the dose of anticoagulants within 8 days after discontinuation of teturam is recommended. Theophylline: teturam inhibits theophylline metabolism. As a result of this, the dose of theophylline should be adjusted (reduced dosage), depending on the clinical symptoms and the plasma concentration of the drug. Benzodiazepines: teturam can potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). Benzodiazepine dosage should be adjusted according to clinical manifestations.Tricyclic antidepressants: it is possible to increase the reaction of intolerance to alcohol (especially if patients are treated with teturam, they take alcohol).
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