Toraxol solution pills pills dispersible 30mg N10
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Active ingredients
Ambroxol
Release form
Pills
Composition
Ambroxol hydrochloride 30 mg. Excipients: microcrystalline cellulose 249.5 mg, crospovidone 20 mg, aspartame 20 mg, blackcurrant flavoring 6.5 mg, sodium fumarate 3.5 mg, sodium saccharinate 4 mg, citric acid 15 mg, colloidal silicon dioxide 1.5 mg.
Pharmacological effect
Mucolytic agent with expectorant action. Stimulates the serous cells of the glands of the mucous membrane of the bronchi, increasing the content of mucous secretion and, thus, alters the disturbed ratio of serous and mucous components of sputum. This activates the hydrolyzing enzymes, and increases the release of lysosomes from Clara cells, which leads to a decrease in sputum viscosity. Ambroxol increases the content of surfactant in the lungs, which is associated with an increase in its synthesis and secretion in the alveolar pneumocytes, as well as a violation of its decay. Increases mucociliary transport of sputum. Slightly suppresses cough.
Pharmacokinetics
After oral administration, Ambroxol is almost completely absorbed from the gastrointestinal tract. Cmax in plasma is reached in approximately 0.5-3 hours. Does not cumulate. Plasma protein binding is about 90%. After ingestion and parenteral administration, Ambroxol is rapidly distributed in body tissues, the highest concentration is determined in the lungs. It penetrates the BBB and placental barrier, is excreted in breast milk. Metabolized in the liver by conjugation with the formation of pharmacologically inactive metabolites. T1 / 2 is 7-12 hours. It is mainly excreted by the kidneys as metabolites - 90%, unchanged - 5%. T1 / 2 increases with severe chronic renal failure.
Indications
Acute and chronic diseases of the respiratory tract, accompanied by the release of viscous sputum (chronic bronchitis with broncho-obstructive syndrome, bronchial asthma, bronchiectasis). Respiratory distress syndrome in newborns and premature babies. ICD-10 codes
Contraindications
Peptic ulcer and duodenal ulcer, convulsive syndrome of various etiologies, I trimester of pregnancy, hypersensitivity to Ambroxol.
Dosage and administration
Inside adults and children over 12 years old - 30 mg 2-3 times / day.The dosage regimen for children under the age of 12 is presented in the following table. In the form of inhalations for adults and children over 5 years of age, 15-22.5 mg 1-2 times / day. Adults parenterally (w / m, w / w) - 15 mg, in severe cases - 30 mg 2-3 times / day. Children i / m - 1.2-1.6 mg / kg 3 times / day; in / in - 1.2-1.6 mg / kg / day. Children under the age of 2 years in / in - 15 mg / day, the frequency of administration - 2 times / day. Children from 2 to 5 years in / in - 22.5 mg / day, the frequency of administration - 3 times / day. Children older than 5 years - 30-45 mg / day, the frequency of administration - 2-3 times / day. For the treatment of respiratory distress syndrome in premature and newborn babies, Ambroxol is administered intravenously or intramuscularly at a dose of 10 mg / kg / day, the frequency of administration is 3-4 times / day, if necessary, the dose can be gradually increased to 30 mg / kg per day