Ambrohexal pills 30 mg N20,
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Description
Ingredients Ambroxol hydrochloride 30 mg Excipients: lactose monohydrate - 102 mg, calcium hydrophosphate dihydrate - 50 mg, corn starch - 10 mg, sodium carboxymethyl starch - 4 mg, magnesium colloidal silica - 2 mg. Pharmacological action Mucolytic drug with expectorant action. Possesses sekretomotorny, sekretolitichesky and expectorant action. Stimulates the serous cells of the bronchial mucosa, increases the content of mucous secretions and the release of surfactant (surfactant) in the alveoli and bronchi, normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and enhancing the release of lysosomes from Clara cells, Ambroxol reduces the viscosity of sputum. Increases motor activity of ciliated epithelium, increases mucociliary transport, facilitates the excretion of sputum from the respiratory tract. When taking ambroxol inside the effect, on average, occurs after 30 minutes and lasts 6-12 hours, depending on the size of a single dose.
Dosage and administration
During treatment with the drug Ambrohexal. It is necessary to use a lot of fluids (juices, tea, water) to enhance the mucolytic effect of the drug. The duration of treatment with the drug Ambrohexal. determined by the doctor individually and depends on the severity of the disease. If necessary, the use of the drug for more than 4-5 days requires consultation with a doctor Tablets The drug should be taken orally after a meal with a sufficient amount of liquid. Adults and children over the age of 12 are prescribed 1 tab. (30 mg) 3 times / day during the first 2-3 days. Then the dose should be reduced to 1 tab. 2 times / day. Children aged 6 to 12 years appoint 1/2 tab. (15 mg) 2-3 times / day. Syrup 3 mg / 1 ml The drug should be taken orally after meals. 1 scoop ambrohexal syrup. (5 ml) contains 15 mg of ambroxol hydrochloride. Adults and children over the age of 12 should be given 2 scoops 2–3 times / day (60–90 mg / day) for the first 2–3 days, then 2 scoops 2 times / day (60 mg / day). In severe cases of the disease, the dose is not reduced during the entire course of treatment. The maximum dose is 4 scoops (60 mg) 2 times / day (120 mg / day). Children between the ages of 5 and 12 are prescribed 1 scoop 2-3 times / day (30-45 mg / day).Children aged 2 to 5 years old appoint 1/2 measuring spoon 3 times / day (22.5 mg / day). Children under the age of 2 should be given 1/2 teaspoonful after 2 times / day (15 mg / day). The drug is prescribed only under the supervision of a physician. Syrup 6 mg / 1 ml The drug should be taken orally. Adults and children over the age of 12 are prescribed 1 scoop (5 ml) 3 times / day for the first 2-3 days, then 1 scoop (5 ml) 2 times / day. Children aged 6 to 12 years old appoint 1/2 measuring spoon (2.5 ml) 2-3 times / day. Children aged 2 to 6 years old appoint 1/4 scoop (1.25 ml) 3 times / day. Children under 2 years: 1/4 scoop (1.25 ml), 2 times / day. The drug is prescribed only under the supervision of a physician. Solution for ingestion and inhalation Ingestion The drug should be taken orally after a meal in a diluted form with tea, fruit juices, milk or water. 1 ml of solution (20 drops) contains 7.5 mg of ambroxol hydrochloride. Adults and children over the age of 12 are prescribed 4 ml (80 drops) 3 times / day (90 mg / day) in the first 2-3 days, then 4 ml (80 drops) 2 times / day (60 mg / day ). Children aged 5 to 12 years old are prescribed 2 ml (40 drops) 2-3 times / day (30-45 mg / day). Children aged 2 to 5 years old should be prescribed 1 ml (20 drops) 3 times / day (22.5 mg / day). Children under 2 years old are prescribed 1 ml (20 drops) 2 times / day (15 mg / day). The drug is prescribed only under the supervision of a physician. Inhalation Use Adults and children over the age of 5 years are recommended to take inhalations 1-2 times / day in 2-3 ml (40-60 drops, which corresponds to 15-45 mg of ambroxol). Children under the age of 5 years old are recommended to take inhalations 1-2 times / day in 2 ml (40 drops, which corresponds to 15-30 mg of ambroxol). The solution for inhalation can be applied using any modern equipment for inhalation (except steam inhalers). The drug is mixed with saline, to achieve the optimal level of air humidification in the respirator, the drug can be diluted in a 1: 1 ratio. Since during inhalation therapy, a deep breath can provoke cough tremors, inhalation should be carried out in the normal breathing regimen. Before inhalation, it is usually recommended to warm the inhalation solution to body temperature. Patients with bronchial asthma can be recommended inhalation after taking bronchodilators. Precautions During the period of treatment may worsen psoriasis.With pheochromocytoma, propranolol can be used only after taking an alpha blocker. After a long course of treatment, propranolol should be discontinued gradually, under the supervision of a physician. Against the background of treatment with propranolol, IV administration of verapamil, diltiazem should be avoided. A few days before anesthesia, you must stop taking propranolol or pick up a remedy for anesthesia with minimal negative inotropic effects. Influence on the ability to drive vehicles and control mechanisms In patients whose activities require increased attention, the question of the use of propranolol on an outpatient basis should be addressed only after evaluating the individual response of the patient. Side effect Classification of undesirable effects according to the frequency of their development (WHO): very often (& # 8805 .1 / 10), often (from & # 8805 .1 / 100 to <1/10), infrequently (from & # 8805 .1 / 1000 to <1/100), rarely (from & # 8805 .1 / 10 000 to <1/1000), very rarely (<1/10 000), the frequency is unknown - according to the available data, it was not possible to establish the frequency of occurrence possible. Allergic reactions: rarely - skin rash, urticaria. frequency unknown - anaphylactic reactions, including anaphylactic shock, angioedema, pruritus and other hypersensitivity reactions. For syrup 6 mg / ml in addition: rarely - rash, swelling of the face, shortness of breath, itching, fever. very rarely - angioedema. frequency unknown - allergic contact dermatitis. On the part of the digestive system: often - nausea. infrequently - vomiting, diarrhea, dyspepsia, abdominal pain. For syrup 3 mg / ml in addition: infrequently - heartburn. For syrup 6 mg / ml: often - oral and pharyngeal hypesthesia. infrequently - with prolonged use in high doses - gastralgia, nausea, vomiting. rarely diarrhea. On the part of the nervous system: often - a change in taste. For the skin: for syrup 6 mg / ml: very rarely - severe skin reactions (epidermal necrolysis, Stevens-Johnson syndrome). Others: often - decreased sensitivity in the mouth or pharynx. infrequently - dry mouth. frequency is unknown - dryness of the mucous membranes of the respiratory tract. For syrup 6 mg / ml: rarely - dry mouth and respiratory tract, rhinorrhea, dysuria, weakness, headache. Cautions Ambroxol should not be taken simultaneously with antitussive drugs that can inhibit the cough reflex, such as codeine, because this may make it difficult to remove liquefied sputum from the bronchi.Ambroxol should be used with caution in patients with a weakened cough reflex or impaired mucociliary transport due to the possibility of sputum accumulation. Patients taking Ambroxol are not recommended to perform breathing exercises due to difficulty in sputum discharge. In patients in serious condition, aspirated liquefied sputum should be performed. Do not take Ambroxol just before bedtime. In patients with asthma, ambroxol may increase cough. In patients with severe skin lesions — Stevens-Johnson syndrome or toxic epidermal necrolysis — an flu-like condition can be observed in the early phase: fever, body aches, rhinitis, cough, pharyngitis. With symptomatic therapy, erroneous administration of mucolytic agents, such as ambroxol hydrochloride, is possible. There are isolated reports on the detection of Stevens-Johnson syndrome and toxic epidermal necrolysis, which coincided with the appointment of the drug. However, a causal relationship with taking the drug is missing. With the development of the above syndromes, it is recommended to stop taking the drug. the patient should consult a doctor immediately. The solution for ingestion and inhalation contains sodium metabisulfite (preservative), which can cause the development of hypersensitivity reactions (especially in patients with bronchial asthma), which manifests itself in the form of vomiting, diarrhea, bronchospasm attacks, impaired consciousness or anaphylactic shock. These reactions can be very individual, and also lead to life-threatening consequences. For syrup of 6 mg / ml in addition: in case of motility disorders of the bronchi and an increase in the amount of secretion (for example, fixed cilia syndrome) because of the danger of mucus accumulation, the drug can be taken only after consulting with the attending physician and under medical supervision. In severe impaired renal function and liver, it is necessary to use lower concentrations, or increase the interval between doses of the drug. The instruction for patients with a diabetes mellitus: 1 tablet contains less than 0.01 XE. 1 scoop (5 ml) of 3 mg / ml syrup contains 1.75 g of sorbitol (less than 0.15 XE). 1 scoop (5 ml) of 6 mg / ml syrup contains 2.525 g of sorbitol (0.21 XE).Influence on ability to drive motor transport and control mechanisms Ambrohexal. does not have a negative impact on the ability to drive vehicles or work with mechanisms. Use during pregnancy and breastfeeding The drug is contraindicated for use in the first trimester of pregnancy. The use of the drug in the II and III trimesters of pregnancy is possible only in the case when the intended benefit to the mother outweighs the potential risk to the fetus. Ambroxol penetrates the placental barrier. Experimental studies on animals have shown that the drug does not affect embryo-fetal development, childbirth and postnatal development. Ambroxol in small quantities is excreted in breast milk, so when using the drug Ambrohexal. It is necessary to resolve the issue of stopping breastfeeding. Type: Medicine Quantity in the package, pcs: 20 Shelf life: 60 months Active ingredient: Ambroxol (Ambroxol) Route of administration: Oral Vacation procedure: No prescription Release form: No prescription Storage conditions: In a dry place, In a dark place Keep out of reach of children Maximum storage temperature, ° С: 25 Pharmacological group: R05CB06 Ambroxol Minimum age: 6 yearsActive ingredients
Release form
Pills
Composition
Ambroxol hydrochloride 30 mg Auxiliary substances: lactose monohydrate - 102 mg, calcium hydrogen phosphate dihydrate - 50 mg, corn starch - 10 mg, sodium carboxymethyl starch - 4 mg, magnesium stearate - 2 mg.
Pharmacological effect
Mucolytic drug with expectorant action. Possesses sekretomotorny, sekretolitichesky and expectorant action. Stimulates the serous cells of the bronchial mucosa, increases the content of mucous secretions and the release of surfactant (surfactant) in the alveoli and bronchi, normalizes the disturbed ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and enhancing the release of lysosomes from Clara cells, Ambroxol reduces the viscosity of sputum. Increases motor activity of ciliated epithelium, increases mucociliary transport, facilitates the excretion of sputum from the respiratory tract. When taking ambroxol inside the effect, on average, occurs after 30 minutes and lasts 6-12 hours, depending on the size of a single dose.
Indications
Acute and chronic diseases of the respiratory tract with the release of viscous sputum: - Acute and chronic bronchitis. - pneumonia. - COPD. - bronchial asthma with the difficulty of sputum discharge. - bronchiectasis. - treatment and prevention of respiratory distress syndrome (for syrup 3 mg / ml and oral solution and inhalation).
Contraindications
- I trimester of pregnancy. - lactation period (breastfeeding). - children's age up to 6 years (for pills). - Lactase deficiency, lactose intolerance, glucose-galactose malabsorption (for pills). - hereditary intolerance to fructose (for syrup). - Hypersensitivity to Ambroxol and other components of the drug dosage forms. With caution should use the drug for gastric ulcer and duodenal ulcer (due to possible exacerbation), renal failure, liver failure, in the II and III trimesters of pregnancy.
Use during pregnancy and lactation
The drug is contraindicated for use in the first trimester of pregnancy. The use of the drug in the II and III trimesters of pregnancy is possible only in the case when the intended benefit to the mother outweighs the potential risk to the fetus. Ambroxol penetrates the placental barrier. Experimental studies on animals have shown that the drug does not affect embryo-fetal development, childbirth and postnatal development. Ambroxol in small quantities is excreted in breast milk, so when using the drug Ambrohexal. It is necessary to resolve the issue of stopping breastfeeding.
Dosage and administration
During treatment with the drug Ambrohexal. It is necessary to use a lot of fluids (juices, tea, water) to enhance the mucolytic effect of the drug. The duration of treatment with the drug Ambrohexal. determined by the doctor individually and depends on the severity of the disease. If necessary, the use of the drug for more than 4-5 days requires consultation with a doctor Tablets The drug should be taken orally after a meal with a sufficient amount of liquid. Adults and children over the age of 12 are prescribed 1 tab. (30 mg) 3 times / day during the first 2-3 days. Then the dose should be reduced to 1 tab.2 times / day. Children aged 6 to 12 years appoint 1/2 tab. (15 mg) 2-3 times / day. Syrup 3 mg / 1 ml The drug should be taken orally after meals. 1 scoop ambrohexal syrup. (5 ml) contains 15 mg of ambroxol hydrochloride. Adults and children over the age of 12 should be given 2 scoops 2–3 times / day (60–90 mg / day) for the first 2–3 days, then 2 scoops 2 times / day (60 mg / day). In severe cases of the disease, the dose is not reduced during the entire course of treatment. The maximum dose is 4 scoops (60 mg) 2 times / day (120 mg / day). Children between the ages of 5 and 12 are prescribed 1 scoop 2-3 times / day (30-45 mg / day). Children aged 2 to 5 years old appoint 1/2 measuring spoon 3 times / day (22.5 mg / day). Children under the age of 2 should be given 1/2 teaspoonful after 2 times / day (15 mg / day). The drug is prescribed only under the supervision of a physician. Syrup 6 mg / 1 ml The drug should be taken orally. Adults and children over the age of 12 are prescribed 1 scoop (5 ml) 3 times / day for the first 2-3 days, then 1 scoop (5 ml) 2 times / day. Children aged 6 to 12 years old appoint 1/2 measuring spoon (2.5 ml) 2-3 times / day. Children aged 2 to 6 years old appoint 1/4 scoop (1.25 ml) 3 times / day. Children under 2 years: 1/4 scoop (1.25 ml), 2 times / day. The drug is prescribed only under the supervision of a physician. Solution for ingestion and inhalation Ingestion The drug should be taken orally after a meal in a diluted form with tea, fruit juices, milk or water. 1 ml of solution (20 drops) contains 7.5 mg of ambroxol hydrochloride. Adults and children over the age of 12 are prescribed 4 ml (80 drops) 3 times / day (90 mg / day) in the first 2-3 days, then 4 ml (80 drops) 2 times / day (60 mg / day ). Children aged 5 to 12 years old are prescribed 2 ml (40 drops) 2-3 times / day (30-45 mg / day). Children aged 2 to 5 years old should be prescribed 1 ml (20 drops) 3 times / day (22.5 mg / day). Children under 2 years old are prescribed 1 ml (20 drops) 2 times / day (15 mg / day). The drug is prescribed only under the supervision of a physician. Inhalation Use Adults and children over the age of 5 years are recommended to take inhalations 1-2 times / day in 2-3 ml (40-60 drops, which corresponds to 15-45 mg of ambroxol). Children under the age of 5 years old are recommended to take inhalations 1-2 times / day in 2 ml (40 drops, which corresponds to 15-30 mg of ambroxol). The solution for inhalation can be applied using any modern equipment for inhalation (except steam inhalers). The drug is mixed with saline, to achieve the optimal level of air humidification in the respirator, the drug can be diluted in a 1: 1 ratio. Since during inhalation therapy, a deep breath can provoke cough tremors, inhalation should be carried out in the normal breathing regimen.Before inhalation, it is usually recommended to warm the inhalation solution to body temperature. Patients with bronchial asthma can be recommended inhalation after taking bronchodilators.
Side effects
The classification of undesirable effects according to the frequency of their development (WHO): very often (& # 8805 .1 / 10), often (from & # 8805 .1 / 100 to <1/10), infrequently (from & # 8805 .1 / 1000 to <1/100), rarely (from & # 8805 .1 / 10 000 to <1/1000), very rarely (<1/10 000), the frequency is unknown - according to the available data, it was impossible to establish the frequency of occurrence. Allergic reactions: rarely - skin rash, urticaria. frequency unknown - anaphylactic reactions, including anaphylactic shock, angioedema, pruritus and other hypersensitivity reactions. For syrup 6 mg / ml in addition: rarely - rash, swelling of the face, shortness of breath, itching, fever. very rarely - angioedema. frequency unknown - allergic contact dermatitis. On the part of the digestive system: often - nausea. infrequently - vomiting, diarrhea, dyspepsia, abdominal pain. For syrup 3 mg / ml in addition: infrequently - heartburn. For syrup 6 mg / ml: often - oral and pharyngeal hypesthesia. infrequently - with prolonged use in high doses - gastralgia, nausea, vomiting. rarely diarrhea. On the part of the nervous system: often - a change in taste. For the skin: for syrup 6 mg / ml: very rarely - severe skin reactions (epidermal necrolysis, Stevens-Johnson syndrome). Others: often - decreased sensitivity in the mouth or pharynx. infrequently - dry mouth. frequency is unknown - dryness of the mucous membranes of the respiratory tract. For syrup 6 mg / ml: rarely - dry mouth and respiratory tract, rhinorrhea, dysuria, weakness, headache.
special instructions
The classification of undesirable effects according to the frequency of their development (WHO): very often (& # 8805 .1 / 10), often (from & # 8805 .1 / 100 to <1/10), infrequently (from & # 8805 .1 / 1000 to <1/100), rarely (from & # 8805 .1 / 10 000 to <1/1000), very rarely (<1/10 000), the frequency is unknown - according to the available data, it was impossible to establish the frequency of occurrence. Allergic reactions: rarely - skin rash, urticaria. frequency unknown - anaphylactic reactions, including anaphylactic shock, angioedema, pruritus and other hypersensitivity reactions. For syrup 6 mg / ml in addition: rarely - rash, swelling of the face, shortness of breath, itching, fever. very rarely - angioedema. frequency unknown - allergic contact dermatitis. On the part of the digestive system: often - nausea. infrequently - vomiting, diarrhea, dyspepsia, abdominal pain.For syrup 3 mg / ml in addition: infrequently - heartburn. For syrup 6 mg / ml: often - oral and pharyngeal hypesthesia. infrequently - with prolonged use in high doses - gastralgia, nausea, vomiting. rarely diarrhea. On the part of the nervous system: often - a change in taste. For the skin: for syrup 6 mg / ml: very rarely - severe skin reactions (epidermal necrolysis, Stevens-Johnson syndrome). Others: often - decreased sensitivity in the mouth or pharynx. infrequently - dry mouth. frequency is unknown - dryness of the mucous membranes of the respiratory tract. For syrup 6 mg / ml: rarely - dry mouth and respiratory tract, rhinorrhea, dysuria, weakness, headache.