Amoxiclav Quit Tablet pills dispersible 875 mg + 125 mg 14 pcs
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Active ingredients
Amoxicillin + Clavulanic Acid
Release form
Pills
Composition
1 tablet contains: Amoxicillin (as trihydrate) 875 mg and clavulanic acid (as potassium salt) 125 mg
Pharmacological effect
Broad-spectrum antibiotic; It contains semi-synthetic penicillin amoxicillin and an irreversible β-lactamase inhibitor clavulanic acid. Clavulanic acid forms a persistent inactivated complex with these enzymes and ensures the resistance of amoxicillin to the effects of β-lactamases produced by microorganisms. Clavulanic acid, similar in structure to beta-lactam antibiotics, has a weak intrinsic antibacterial activity. producing β-lactamase, including Aerobic gram-positive bacteria:. Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Enterococcus spp, Staphylococcus aureus (methicillin-apart resistant strains), Staphylococcus epidermidis (methicillin-apart resistant strains), Staphylococcus saprophyticus, Listeria spp .; aerobic managment; spp., Shigella spp., Vibrio cholerae, Yersinia enterocolitica, Eikenella corrodens; Gram-positive anaerobes: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Actinomyces israelii, Fusobacterium spp., Prevotella spp., Gram-negative anaerobes: Bacteroides spp.
Pharmacokinetics
AbsorptionAfter taking the drug inside both components are well absorbed from the gastrointestinal tract, food intake does not affect the degree of absorption. Bioavailability of amoxicillin and clavulanic acid when administered orally is 90% and 70%, respectively. Cmax in the blood plasma is reached after 1 h after taking the drug and is (depending on the dose) for amoxicillin 3-12 μg / ml, for clavulanic acid - about 2 μg / ml. Amoxicillin T1 / 2 - 78 min, clavulanic acid - 60-70 min. Distribution Both components are characterized by a good volume of distribution in body fluids and tissues (secret of the paranasal sinuses, synovial fluid, palatine tonsils, middle ear, pleural fluid, saliva, bronchial secret, lungs, uterus, ovaries, liver, prostate gland, muscle tissue, gallbladder, peritoneal fluid). In the urine, the drug is present in high concentrations. Amoxicillin and clavulanic acid do not penetrate through the blood-brain barrier in non-inflammatory cerebral membranes. Active substances penetrate the placental barrier and in the trace concentrations are excreted in breast milk.The degree of binding to plasma proteins is low. Metabolism Amoxicillin is partially metabolized, clavulanic acid is extensively metabolized. Excretion of Amoxicillin is excreted by the kidneys almost unchanged by tubular secretion and glomerular filtration. Clavulanic acid is excreted by glomerular filtration, partly in the form of metabolites. Small amounts can be excreted through the intestines and lungs. T1 / 2 of amoxicillin in adults is about 1 h. T1 / 2 of clavulanate in adults is about 1 h. Pharmacokinetics in special clinical situations. In severe renal failure, T1 / 2 increases to 7.5 h for amoxicillin and 4.5 h for clavulanic acid. Both components are removed hemodialysis and minor amounts of peritoneal dialysis.
Indications
Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - infections of the upper respiratory tract and upper respiratory tract (including acute and chronic sinusitis, acute and chronic otitis media, pharyngeal abscess, tonsillitis, pharyngitis) - lower infections parts of the respiratory tract (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia); urinary tract infections; gynecological infections; infections of the skin and soft tissues, including human and animal bites; ostnoy and connective tissue - biliary tract infection (cholecystitis, cholangitis) - odontogenic infection.
Contraindications
- a history of indications of cholestatic jaundice and / or other abnormalities in liver function caused by taking amoxicillin / clavulanic acid; - children under 12 years old or with a body weight less than 40 kg; - hypersensitivity to the components of the drug; - hypersensitivity in the anamnesis to any antibiotic from the group of penicillins, cephalosporins and to other beta-lactam antibiotics.
Precautionary measures
The drug should be used with caution in patients with pseudomembranous colitis in history, liver failure, severe renal impairment, during lactation. Due to the fact that a large number of patients suffering from infectious mononucleosis and lymphocytic leukemia who received ampicillin, erythematous rash appeared, The use of ampicillin antibiotics for these patients is not recommended.
Use during pregnancy and lactation
Amoxiclav Quiktab can be used during pregnancy with clear indications. Amoxicillin and clavulanic acid are excreted in small quantities with breast milk.
Dosage and administration
Inside Tablets must be dissolved in half a glass of water (at least 30 ml) and thoroughly mixed, drink. It is possible to hold the pills in the mouth until completely dissolved, then swallow. In order to reduce the risk of side effects from the gastrointestinal tract, a drug should be taken at the beginning of a meal. Adults and children over 12 years old (weighing more than 40 kg) with a mild or moderate course of infection are prescribed 1 tab. (625 mg) every 12 hours, in case of severe infection and respiratory infections - 1 tab. (625 mg) every 8 hours or 1 tab. (1000 mg) every 12 hours. Treatment duration - up to 14 days. In case of starting treatment with parenteral administration of the drug, it is possible to continue the ingestion of Amoxiclav Kviktab pills. Depending on the severity of renal impairment, reduce the dose of the drug and / or increase the interval of use. In case of moderate renal failure (CC 10-30 ml / min), 1 tab. (625 mg) every 12 hours. For severe renal failure (CC less than 10 ml / min), 1 tab. (625 mg) every 24 hours. With anuria, the interval between doses should be increased to 48 hours or more.
Side effects
Side effects in most cases are weak and transient. On the part of the digestive system: loss of appetite, nausea, vomiting, diarrhea; rarely - increased activity of liver enzymes (ALT, AST), increased levels of alkaline phosphatase, liver dysfunction; in rare cases - cholestatic jaundice, hepatitis, pseudomembranous colitis. On the CNS side: dizziness, headache; very rarely - convulsions (may occur in patients with impaired renal function when taking the drug in high doses). From the hematopoietic system: rarely - reversible leukopenia (including neutropenia), thrombocytopenia; very rarely - hemolytic anemia, reversible increase in prothrombin time (when used together with anticoagulants). From the urinary system: very rarely - interstitial nephritis, crystalluria. Allergic reactions: erythematous rash, pruritus, urticaria; very rarely - erythema multiforme exudative, angioedema, anaphylactic shock, allergic vasculitis; in rare cases - exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis,acute generalized exantmatous pustullosis. Others: rarely - the development of superinfection (including candidiasis).
Overdose
There are no reports of death or life-threatening side effects due to overdose of the drug. Symptoms: disorders of the gastrointestinal tract - abdominal pain, diarrhea, vomiting; it is also possible anxiety, insomnia, dizziness; in some cases, convulsive seizures. Treatment: symptomatic, in case of a recent intake of the drug (less than 4 hours), it is necessary to carry out a gastric lavage and to appoint activated charcoal to reduce the absorption of the drug. The patient must be under medical supervision. Amoxicillin / potassium clavulanate is removed by hemodialysis.
Interaction with other drugs
With simultaneous use of the drug Amoxiclav Quiktab with antacids, glucosamine, laxatives, aminoglycosides, absorption slows down, and with ascorbic acid it increases. glomerular filtration). With simultaneous use of Amoxiclav Kviktab increases the toxicity of methotrexate. With simultaneous use of the drug Am ksiklav Kviktab with allopurinol increases the incidence of exanthema. Simultaneous use of the drug Amoxiclav Kviktab with disulfiram should be avoided. In some cases, taking the drug can prolong the prothrombin time, therefore, caution should be taken with the simultaneous use of anticoagulants and Amoxiclav Quiktab. (mutual weakening of the antibacterial effect is noted). Amoxiclav Kviktab should be applied several hours before EMA bacteriostatic antibiotics (macrolides, tetracyclines) sulfanilamidov.Probenetsid reduces excretion of amoxicillin, increasing its serum kontsentratsiyu.Amoksiklav Kviktab reduces the effectiveness of oral contraceptives.
special instructions
In a course of treatment, the functions of the blood-forming organs should be monitored,liver and kidney. In patients with severely impaired renal function, an adequate correction of the dosing regimen or an increase in the intervals between doses of the drug is required. To reduce the risk of adverse reactions from the gastrointestinal tract, you should take the drug at the beginning of the meal. When using Amoksiklava Kviktab, a false positive reaction is possible when determining level of glucose in the urine when using Benedict's reagent or Felling's solution (it is recommended to use enzymatic reactions with glucosidase). Effect on the ability to No evidence of the adverse effect of Amoxiclav Kviktab at the recommended doses on the ability to drive and control mechanisms.