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Description
Andipal is a multicomponent combined drug that has an analgesic and antispasmodic effect.
Active ingredients
Bendazole + Metamizole Sodium + Papaverine + Phenobarbital
Release form
Pills
Composition
Bendazole, metamizole sodium, papaverine, phenobarbital
Pharmacological effect
Andipal, as an antispasmodic, is used in spasms of peripheral vessels and vessels of the brain. Reducing the OPSS, acting on arterioles, the drug reduces blood pressure, improves collateral circulation. The combination of myotropic type antispasmodics (Dibazol and papaverine hydrochloride) with analgin enhances the analgesic effect of the latter in headaches and migraines. The presence in the preparation of phenobarbital contributes to the manifestation of a sedative effect and enhance the action of other components.
Pharmacokinetics
After ingestion, metamizole sodium is rapidly hydrolyzed in the gastric juice to form the active metabolite 4-methyl-amino-antipyrine, which, after exhaustion, is metabolized to 4-formyl-amino-antipyrine and other metabolites. Metabolites do not bind to plasma proteins. Most of the drug is excreted in the urine in the form of metabolites. Metabolites are also excreted in breast milk.
Indications
Pain syndrome associated with spasm of peripheral arteries, smooth muscles of the gastrointestinal tract, cerebral vessels, arterial hypertension.
Contraindications
Severe renal / hepatic insufficiency, deficiency of glucose-6-phosphate dehydrogenase, blood diseases, tachyarrhythmia, severe angina, decompensated chronic heart failure, angle-closure glaucoma, prostatic hyperplasia, intestinal obstruction, megacolon, pregnancy, lactation period, lactation period, lactation period, megacolon, pregnancy, lacterema, lacterema, lacterema, lacterema, lacterema, lactation period, lactation, in case of an inoculation, in case of an inoperative diet. , hypersensitivity to the drug.
Use during pregnancy and lactation
Contraindicated
Dosage and administration
Inside, 1 tab. 2-3 times / day
Side effects
On the part of the digestive system: nausea, constipation, abnormal liver function. From the side of the central nervous system: drowsiness, reduced speed of psychomotor reactions. From the hemopoietic system: leukopenia, agranulocytosis. Other: allergic reactions, lowering blood pressure, renal dysfunction.
Overdose
In case of overdose, severe drowsiness, dizziness, collapse state occurs. Treatment: first aid - gastric lavage, taking activated carbon. Symptomatic therapy.
Interaction with other drugs
Enhances the hypotensive effect of nitrates, slow calcium channel blockers, beta-blockers, ganglioblokatorov, diuretics (including furosemide, hypothiazide), myotropic antispasmodics. Mutually increasing the risk of side effects observed with simultaneous use with opioid analgesics. Adsorbents, astringent, enveloping drugs reduce the absorption of the drug in the gastrointestinal tract.
special instructions
With prolonged (more than 7 days) application, control of the pattern of peripheral blood and the functional state of the liver is necessary. Influence on ability to drive motor transport and control mechanisms. During the period of treatment, it is necessary to refrain from engaging in potentially hazardous activities that require high concentration of attention and quickness of psychomotor reactions.