Angioflux capsules 250le N50
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Active ingredients
Sulodexide
Composition
Sulodexide 250 LE * Excipients: glyceryl caprylocaprate (miglyol 812), sodium lauryl sulfate, colloidal silicon dioxide. The composition of the shell of capsules: gelatin, glycerol, ethyl parahydroxybenzoate sodium, propyl parahydroxybenzoate sodium, iron dye red oxide (E172). * - lipoprotein lipase unit.
Pharmacological effect
Anticoagulant agent, heparinoid. It has antiplatelet, antithrombotic, angioprotective, lipid-lowering and fibrinolytic effects. The active substance - an extract from the mucous membrane of the small intestine of animals, is a natural mixture of a fast-moving heparin-like fraction (80%) and dermatan-sulfate (20%). Suppresses activated factor X, enhances the synthesis and secretion of prostacyclin (prostaglandin PgI2), reduces the concentration of fibrinogen in the plasma. Increases the concentration of activator tissue profibrinolizina (plasminogen) in the blood and reduces the concentration in the blood of its inhibitor. The mechanism of angioprotective action is associated with the restoration of the structural and functional integrity of the vascular endothelium cells, as well as the normal density of the negative electric charge of the pores of the basal membrane of the vessels. Normalizes the rheological properties of blood by reducing TG and reducing blood viscosity. Efficiency of use in diabetic nephropathy is determined by a decrease in the thickness of the basement membrane and a decrease in the production of the matrix by reducing the proliferation of mesangium cells. When a / in the introduction of high doses manifested its anticoagulant effect due to inhibition of heparin cofactor II.
Indications
Angiopathies with an increased risk of thrombosis (including after myocardial infarction); violation of cerebral circulation (including acute ischemic stroke and the period of early recovery); dyscirculatory encephalopathy due to atherosclerosis, diabetes mellitus, arterial hypertension; vascular dementia; occlusive lesions of peripheral arteries (including atherosclerotic and diabetic genesis); phlebopathy, deep vein thrombosis; microangiopathies (nephropathy, retinopathy, neuropathy) and macroangiopathies with diabetes mellitus (diabetic foot syndrome,encephalopathy, cardiopathy); thrombotic states, antiphospholipid syndrome (as part of combination therapy with acetylsalicylic acid); to continue therapy in the development of heparin-induced thrombotic thrombocytopenia.
Contraindications
Hemorrhagic diathesis and other diseases, accompanied by a decrease in blood coagulation; pregnancy; Hypersensitivity to sulodeksidu.
Use during pregnancy and lactation
Contraindicated in pregnancy.
Dosage and administration
Individual, depending on the clinical situation.
Side effects
On the part of the digestive system: nausea, vomiting, epigastric pain. Other: skin rash; at the injection site - pain, burning, hematoma.
Overdose
Symptoms: bleeding or bleeding. Treatment: maintenance of vital functions (against the background of drug withdrawal).
Interaction with other drugs
Concurrent use with drugs that affect the hemostatic system (direct and indirect anticoagulants, antiplatelet agents) is not recommended.
special instructions
When using sulodexide, the state of the blood coagulation system (coagulogram) should be regularly monitored. It is not recommended to apply anticoagulants (direct and indirect) and antiplatelet agents simultaneously.