Antigrippin-anvi N20 capsules
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Active ingredients
Acetylsalicylic acid + Ascorbic acid
Release form
Capsules
Composition
Active ingredient: 1 green capsule contains: Acetylsalicylic acid 250 mg. Acorbic acid 300 mg. Rutin 20 mg. 1 white capsule contains: Metamizol 250 mg. Diphenhydramine 20 mg. Calcium gluconate 100 mg. Concentration of active ingredient (mg): 570 mg and 370 mg
Pharmacological effect
The drug of the combined composition. It has analgesic, antipyretic, anti-inflammatory, antiallergic and angioprotective effects. Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects; inhibits platelet aggregation. Ascorbic acid (vitamin C) plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, increases the body's resistance. Rutozid (rutin) is an angioprotector. Reduces capillary permeability, reduces swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of deformation of erythrocytes. Metamizole has analgesic, antipyretic and weak anti-inflammatory action, the mechanism of which is associated with the inhibition of prostaglandin synthesis. Diphenhydramine has an anti-allergic, anti-edema effect. Reduces vascular permeability, eliminates edema and hyperemia of the nasal mucosa, reduces tickling in the throat and allergic reactions from the upper respiratory tract. Calcium gluconate is a regulator of calcium and phosphorus metabolism, reduces vascular permeability. In allergic diseases or conditions, its combined use with antihistamines is recommended.
Pharmacokinetics
Data on the pharmacokinetics of the drug Antigrippin-ANVI not provided.
Indications
Symptomatic treatment of influenza, ARVI, colds in adults and adolescents over 15 years.
Contraindications
The tendency to bruise hypertension. Severe renal dysfunction. Deficiency of glucose-6-phosphate dehydrogenase (includingwith hereditary hemolytic anemia caused by a deficiency of this enzyme). Dissecting aortic aneurysm. Hypercalcemia (calcium ion concentration should not exceed 12 mg% or 6 meq / l). Hypercalciuria. Nephrolithiasis (calcium). Sarcoidosis. Pregnancy. Lactation (breastfeeding). Children and adolescents up to 15 years. Increased sensitivity to the components of the drug. With caution, prescribe the drug for: Hyperuricemia. Urotic nephrolithiasis. Gout. situ of the stomach and duodenum (history) .Dekompensirovannoy heart failure.
Precautionary measures
Do not exceed the recommended dose. With caution, the drug is prescribed for hyperuricemia, urate nephrolithiasis, gout, gastric ulcer and duodenal ulcer (in history), decompensated heart failure.
Use during pregnancy and lactation
The drug is contraindicated for use in pregnancy. If necessary, the appointment during lactation should stop breastfeeding for the period of use of the drug. Acetylsalicylic acid has a teratogenic effect: when used in the first trimester of pregnancy leads to the development of the splitting of the upper palate; in trimester III - to premature closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the pulmonary circulation, and inhibition of labor activity (due to inhibition of prostaglandin synthesis). The acetylsalicylic acid is excreted in breast milk, which increases bleeding in a child due to dysfunction of platelets.
Dosage and administration
The drug is prescribed to adults and adolescents over 15 years old, 2 capsules per reception: 1 green capsule and 1 white capsule. The duration of treatment is 3-5 days before the symptoms of the disease disappear. The capsules are taken orally 2-3 times a day after meals with water. Patient should be warned that in the absence of improvement in health, taking the drug should be stopped and consult a doctor.
Side effects
From the digestive system Anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract,gastrointestinal bleeding, liver failure. Since the cardiovascular systemHeighten blood pressure, tachycardia. Allergic reactions Skin rash, angioedema, bronchospasm (with a tendency to bronchospasm may provoke an attack). Side effects observed with prolonged use of the drug (more than 7 days) On the part of the hematopoietic system: Thrombocytopenia, agranulocytosis, leukopenia. On the part of the CNS Headache, headache, visual disturbances, tinnitus, deafness. On the part of the blood coagulation system; Reduction of platelet aggregation, hypocoagulation, hemorrhagic syndrome (including epistaxis, bleeding gums, purpura). Allergic reactionsAnaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome). Urinary system disorders Kidney damage with papillary necrosis, renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red due to the release of a metabolite. Other Adolescents - Reye's syndrome (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, abnormal liver function).
Overdose
Symptoms: nausea, vomiting, stomach pain, sweating, pale skin, tachycardia; with a slight overdose - ringing in the ears; in severe overdose - drowsiness, collapse, convulsions, bronchospasm, difficulty breathing, anuria, bleeding, progressive respiratory paralysis and respiratory acidosis (due to dissociation of oxidative phosphorylation). Treatment: artificial vomiting, gastric lavage, administration of saline laxatives, activated carbon; with the development of convulsive syndrome - in / in the introduction of diazepam and barbiturates; if necessary - conducting forced diuresis, hemodialysis.
Interaction with other drugs
With the simultaneous use of Antigrippin-ANVI, it enhances the effect of heparin, indirect anticoagulants, reserpine, on-the-top-of-action of psychoactive substances, and on the use of psychoactive drugs.methotrexate, non-narcotic analgesics and NPVS. With simultaneous use of the drug Antigrippin-ANVI with barbiturates, antiepileptic drugs, zidovudine, rifampicin and ethanol-containing drugs increases the risk of hepatotoxic action. These combinations should be avoided. Ascorbic acid improves intestinal absorption of iron preparations. Tricyclic antidepressants, oral contraceptives and allopurinol violate metamizol metabolism in the liver and increase its toxicity. Simultaneous use of metamizole sodium with cyclosporine reduces the level of plasma in the blood plasma. the action of metamizole sodium. When used simultaneously with metamizole sodium, thiamazole and melphalan increase the risk of development leukopenia. Metamizole sodium enhances the effects of alcohol-containing beverages.
special instructions
With prolonged use of the drug, it is necessary to control the picture of peripheral blood and laboratory indicators of the functional state of the liver. Since acetylsalicylic acid has an antiplatelet effect, the patient, if he is to have surgery, must notify the doctor in advance about taking the drug. Low doses of acetylsalicylic acid reduce uric acid excretion may in some cases provoke an attack of gout. The purpose of ascorbic acid in patients with rapidly proliferating and intensively metastatic tumors can aggravate the process. Patients with bronchial asthma and pollinosis can develop hypersensitivity reactions. Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor renal function and AD. It is not recommended to prescribe the drug with anticoagulants, GCS, ticlopidine, uricosuric and antihypertensive agents. Ascorbic acid may distort the results of various laboratory dough (Determination of glucose, bilirubin and liver transaminases, LDH in the plasma) .Rentgenokontrastnye substance colloid blood substitutes and penicillin should not be applied during use metamizol natriya.Na background of the drugpatients should avoid alcohol because of the increased risk of gastrointestinal bleeding. Use in pediatrics The drug is not prescribed as a febrifuge in children under 15 years of age with acute respiratory viral diseases because of the risk of Reye’s syndrome (encephalopathy and acute fatty liver dystrophy with the acute development of liver failure). The effect on the ability to drive vehicles and control mechanisms In the period of use of the drug should be refrained from activities potentially hazardous activities that require increased attention and psychomotor speed reactions.