Biseptol 480 concentrate solution for infusion 5ml ampoules N10
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Co-trimoxazole [Sulfamethoxazole + Trimethoprim]
Composition
Sulfamethoxazole 80 mg 400 mg, trimethoprim 16 mg 80 mg. Excipients: propylene glycol, sodium hydroxide, ethanol, benzyl alcohol, sodium metabisulfite, water d / and.
Pharmacological effect
Combined antibacterial drug containing sulfamethoxazole, which has an average duration of action, inhibits the synthesis of folic acid by competitive antagonism with para-aminobenzoic acid, as well as trimetholrim-inhibitor of bacterial reductase dihydrofolic acid. The combination of both drugs gives an energetic effect of antibacterial action and therefore bacterial resistance appears less frequently than other drugs. Biseptol has a broad spectrum of antibacterial action. It is active against: Streptococcus (Streptococcus pneumoniae), Neisseria meningitidis, Neisseria gonorrhoeae (including enterotoxogenic strains), Staphylococcus, Escherichia coli, Klebsiella, Enterobacter, Proteus mirabilis, Proteus sp. (including Salmonella typhi and Salmonella paratyphi), Vibrio cholerae, Bacillus anthracis, Listeria spp., Nocardia asteroides, Bordclella pertussis, Enterococcus faecalis, Pasteurella spp., Brucella spp., Mycobacterium spp. (including Mycobacterium leprae), Citrobacter, Enterobacter spp., Legionella pneumonia, Providencia, some species of Pseudomonas (except P. aerugenosa), Serratia marcescens, Yersinia spp., Morganella spp., Chlamydia spp. (including Chlamydia trachomatis, Chlamydia psittaci), Shigella, Plasmodium spp., Toxoplasma gondii, Pneumocystis carini, Actinomyces Israelii, Coccidioides immitis, Histoplasma capsulatum, Leishmania spp. Resistant to the drug: Corynebacterium spp., Pseudomonas aerugenosa, Mycobacterium tuberculosis, Troponema spp., Leptospira spp., Viruses. It inhibits the vital activity of Escherichia coli, leads to a decrease in the synthesis of thiamine, riboflavin, nicotinic acid and other B vitamins in the intestine. The duration of the therapeutic effect is 7 hours.
Indications
- acute and chronic infections of the urogenital organs: urethritis, pyelonephritis, cystitis, pyelitis, prostatitis, opididymitis, gonorrhea, soft chancre, venereal lymphogranuloma, inguinal granuloma - respiratory tract infections: bronchitis (acute and chronic) bronchiectasis, croupous pneumonia, pneumonia, pneumonia, respiratory infections: bronchitis (acute and chronic) bronchiectasis, croupous pneumonia, pneumonia, pneumonia, respiratory tract infections: bronchitis (acute and chronic) bronchiectasis, croupous pneumonia, pneumonia, respiratory tract infections: bronchitis (acute and chronic) bronchiectasis, croupous pneumonia, pneumonia, respiratory tract infections: bronchitis (acute and chronic) bronchiectasis, croupous pneumonia, pneumonia, respiratory tract infections: bronchitis (acute and chronic) bronchiectasis, croupous pneumonia, pneumonia; pneumonia, empyema, lung abscess - infections of the upper respiratory tract: otitis media, sinusitis, laryngitis, sore throat, scarlet fever - gastrointestinal infections: typhoid fever, paratyphoid fever, salmonellosis, cholera, dysentery, cholecystitis, cholera ngit, gastroenteritis caused by enteric-toxic strains of E.coli - infections of the skin and soft tissues: acne, furunculosis, pyoderma, abscess and wound infections, infections after surgical interventions - sepsis, acute brucellosis, toxoplasmosis, osteomyelitis, osteoarthritis, acute infections, I-acI, I, I, I, I, I, I, I, I, I, I, I have, I, I, I, I, I, o Plasmodium falciparum), whooping cough (as part of complex therapy).
Contraindications
- megaloblastic anemia in the background of folic acid deficiency, aplastic anemia, B12-deficient anemia, agranulocytosis, leukopenia - glucose-6-phosphate dehydrogenase deficiency - hyperbilirubinemia in children - hepatic and / or renal insufficiency clearance of creatinine less than 15 ml / min / m / min). years (for intramuscular administration only) - pregnancy - lactation period - increased individual sensitivity to sulfonamides or trimethoprim. Do not use the drug in premature babies and infants up to 2 months of age. It is used with caution in cases of folic acid deficiency, bronchial asthma, thyroid diseases, abnormal liver and kidney function.
Use during pregnancy and lactation
You should not prescribe the drug during pregnancy and during breastfeeding.
Dosage and administration
The drug should be administered in / in the drip, after dilution (for example, 5% dextrose solution, 0.9% sodium chloride solution, Ringer's solution or 0.45% sodium chloride solution with 2.5% dextrose solution). Solution for infusion should be prepared immediately before administration, thoroughly mixed. After dilution, the resulting solution should be used within 6 hours. Do not use the drug in the form of a quick intravenous injection. Adults and children over 12 years old are prescribed 960 mg each (2 ampoules of 5 ml diluted in 250 ml of solution) every 12 hours. In severe cases, 1440 mg (3 ampoules) should be administered 2-3 times / day. Children under the age of 12 years, the daily dose is prescribed at the rate of 36 mg / kg body weight in two equal doses. Patients with renal insufficiency (with creatine clearance 15-30 ml / min) are prescribed 50% of the average therapeutic dose.
Side effects
Biseptol is usually well tolerated. However, the following effects may be noted: On the part of the gastrointestinal tract: anorexia, gastritis, abdominal pain, glossitis, stomatitis, cholestasis, increased activity of hepatic transaminases, hepatitis, pseudomembranous enterocolitis, nausea, vomiting, diarrhea, liver necrosis. From the side of the central nervous system: headaches and dizziness. In some cases, aseptic meningitis, depression, apathy, tremor, peripheral neuritis. On the part of the respiratory system: bronchospasm, pulmonary infiltrates. From the side of blood formation organs: rarely - neutropenia, agranulocytosis, megaloblastic anemia, leukopenia, thrombocytopenia, hypoprothrombinemia.On the part of the urinary system: polyuria, interstitial nephritis, renal dysfunction, crystalluria, hematuria, increased urea, hypocreatininemia, toxic nephropathy with oliguria and anuria. From the musculoskeletal system: arthralgia, myalgia. Allergic reactions: skin rash and itching, photosensitivity, rash, polymorphic erythema, exfoliative dermatitis, allergic myocarditis, fever, angioedema, sclera redness. Local reactions: thrombophlebitis (at the site of venipuncture), pain at the injection site. Other: hypoglycemia
special instructions
Biseptol is usually well tolerated. However, the following effects may be noted: On the part of the gastrointestinal tract: anorexia, gastritis, abdominal pain, glossitis, stomatitis, cholestasis, increased activity of hepatic transaminases, hepatitis, pseudomembranous enterocolitis, nausea, vomiting, diarrhea, liver necrosis. From the side of the central nervous system: headaches and dizziness. In some cases, aseptic meningitis, depression, apathy, tremor, peripheral neuritis. On the part of the respiratory system: bronchospasm, pulmonary infiltrates. From the side of blood formation organs: rarely - neutropenia, agranulocytosis, megaloblastic anemia, leukopenia, thrombocytopenia, hypoprothrombinemia. On the part of the urinary system: polyuria, interstitial nephritis, renal dysfunction, crystalluria, hematuria, increased urea, hypocreatininemia, toxic nephropathy with oliguria and anuria. From the musculoskeletal system: arthralgia, myalgia. Allergic reactions: skin rash and itching, photosensitivity, rash, polymorphic erythema, exfoliative dermatitis, allergic myocarditis, fever, angioedema, sclera redness. Local reactions: thrombophlebitis (at the site of venipuncture), pain at the injection site. Other: hypoglycemia