Blamaren effervescent pills 80 pcs
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Active ingredients
Sodium citrate
Release form
Pills
Composition
Active ingredient: Sodium citrate (Sodium citrate). Concentration of active ingredient (mg): Citric acid 1197 mg, potassium bicarbonate 967, 5 mg, sodium citrate 835, 5 mg
Pharmacological effect
Dissolves and prevents the formation of uric acid stones due to alkalization of urine to pH values of 6.6 - 6.8 (when urine pH is within 6.6 - 6.8, dissolution of uric acid salt increases significantly). In addition, it reduces calcium excretion, improves the solubility of calcium oxalate in urine, inhibits the formation of crystals and, therefore, prevents the formation of calcium oxalate stones.
Pharmacokinetics
Bioavailability is about 100%. Excreted by the kidneys.
Indications
Prevention of formation and dissolution of uric acid and calcium oxalate stones. Dissolution of mixed uric acid-oxalate stones (with oxalate content less than 25%). Alkalinization of urine in persons receiving cytostatics or drugs that increase the excretion of uric acid. Symptomatic treatment of skin porphyria.
Contraindications
Hypersensitivity to the drug. Renal failure. Urinary tract infections caused by bacteria that decompose urea (the risk of struvite stones). Metabolic alkalosis. Episodic hereditary adynamia.
Precautionary measures
The ability to influence the reaction rate when driving vehicles or other mechanisms. Does not affect. Children. The efficacy and safety of the drug in children have not been studied enough, so it is not recommended to prescribe it to patients of this age group.
Use during pregnancy and lactation
There are no data on the safety of use of Blamaren during pregnancy and lactation, and therefore it is not recommended to use the drug during these periods.
Dosage and administration
Inside, after eating, pre-dissolved in 200 ml of liquid (tea, fruit juice or alkaline mineral water). Daily dose, 2-6 pills. spike. The daily dose is evenly distributed throughout the day. The dose is considered to be properly selected if the pH is within 6, 2–7 during the day (for dissolving uric acid stones). 7, 5–8, 5 (for cystine stones). 7, 2-7, 5 (for the treatment of porphyria).at least 7 (when treated with cytostatics). If the urine pH value is lower than the specified one, the dose should be increased, if higher, reduced. Duration of treatment, 4-6 months. Efficiency monitoring (determination of urine pH) is carried out 3 times a day, before taking each single dose, using indicator paper. The resulting color on paper is compared within 2 minutes with the scale and the resulting value is entered into the control calendar. In the presence of cystine stones and the treatment of porphyria, special indicator paper with a pH value of from 7, 2 to 9, 7 should be used to control the effectiveness.
Side effects
Possible: allergic reactions, edema (sodium retention), metabolic alkalosis, dyspepsia
Overdose
Data on drug overdose Blemaren not provided.
Interaction with other drugs
The simultaneous use of drugs containing citrates and aluminum, can lead to increased absorption of aluminum. The interval between doses of such drugs should be at least 2 hours. The effect of cardiac glycosides may be weakened, “if they are combined with Blemaren, due to the presence of potassium in the preparation. Some blood pressure lowering drugs (aldosterone antagonists, potassium-sparing diuretics, angiotensin-converting enzyme blockers), as well as anti-inflammatory nonsteroidal drugs and analgesics can reduce the excretion of potassium. The possibility of simultaneous reception of such funds is established by a doctor.
special instructions
The average daily dose (12 g of granulated powder or 4 effervescent pills} contains about 1. 5 mg of potassium and 0.9 g of sodium (should be considered in patients with restricted consumption of salt). Can be used in chronic renal failure, not accompanied by a delay of potassium ions It can be prescribed to patients with diabetes mellitus.During the dissolution of uric acid stones should not exceed the daily dose, since an increase in pH above 7.0, phosphates precipitate on the urate crystals, which prevents their further dissolution. of the treatment should limit intake of foods rich in proteins and purine bases, and to provide adequate fluid intake (not less than 1.5-2 liters).