Cerebrolysin injection solution ampoules 2 ml 10 pcs

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Active ingredients

Cerebrolysin concentrate

Release form

Solution

Composition

1 ml solution for injection contains: active substance: concentrate of cerebrolysin (a complex of peptides derived from the brain of a pig) 215.2 mg, excipients: sodium hydroxide, water for injection.

Pharmacological effect

The complex composition of Cerebrolysin, the active fraction of which consists of a balanced and stable mixture of biologically active oligopeptides with a total polyfunctional effect, does not allow for the usual pharmacokinetic analysis of individual components.

Pharmacokinetics

The complex composition of Cerebrolysin, the active fraction of which consists of a balanced and stable mixture of biologically active oligopeptides with a total polyfunctional effect, does not allow for the usual pharmacokinetic analysis of individual components.

Indications

Alzheimer's disease. Syndrome of dementia of various genesis. Chronic cerebrovascular insufficiency. Ischemic stroke. Traumatic injuries of the brain and spinal cord. Delayed mental development in children. Hyperactivity and attention deficit in children. In complex therapy for endogenous depression resistant to anti-depressants.

Contraindications

Individual intolerance to the drug. Acute renal failure. Epileptic status.

Precautionary measures

With excessively rapid administration, in rare cases, a sensation of heat, sweating, dizziness, and in rare instances - rapid heartbeat or arrhythmias. Therefore, the drug should be administered slowly. The compatibility of the drug (for 24 hours at room temperature and light) with the following standard solutions for infusions has been checked and confirmed: - 0.9% sodium chloride-Ringer's solution (Na + - 153.98 mmol / l ; Ca2 + - 2.74 mmol / l; K + - 4.02 mmol / l; Cl- - 163.48 mmol / l) - 5% glucose solution. Simultaneous prescription of vitamins and drugs that improve heart circulation is allowed, but these drugs do not mix in the same syringe with Cerebrolysin. Use only clear solution and only once.

Use during pregnancy and lactation

Caution should be used Cerebrolysin in the first trimester of pregnancy and lactation.The use of the drug during pregnancy and during breastfeeding is possible only in the case when the intended benefits to the mother outweigh the potential risk to the fetus / newborn. The results of experimental studies do not suggest that Cerebrolysin has any teratogenic effect or has a toxic effect on the fetus. However, similar clinical studies have not been conducted.

Dosage and administration

Intramuscularly (up to 5 ml), intravenously (up to 10 ml), intravenously, by slow infusion (from 10 to 50 ml). Doses and duration of treatment depend on the nature and severity of the disease, as well as on the age of the patient. You can assign single doses, the value of which can reach 50 ml, but more preferably a course of treatment. The recommended optimal course of treatment is daily injections for 10–20 days. Acute conditions (ischemic stroke, TBI, complications after neurosurgical operations) - from 10 to 50 ml. The residual period of cerebral stroke and traumatic injury of the brain and spinal cord is from 5 to 50 ml. Psychoorganic syndrome and depression - from 5 to 30 ml. Alzheimer's disease, dementia of vascular and combined Alzheimer's-vascular genesis - from 5 to 30 ml. In neuropediatric practice - 0.1-0.2 ml / kg. To improve the effectiveness of treatment, repeated courses may be conducted, until the patient's condition is improved due to treatment. After the first course, the frequency of dose can be reduced to 2 or 3 times a week. Doses from 10 to 50 ml are recommended to be administered only through slow intravenous infusions after dilution with the proposed standard solutions for infusions. The duration of infusion is from 15 to 60 minutes.

Side effects

Reaction to the introduction of an excessively rapid introduction in rare cases, you may feel the heat, sweating, dizziness. in isolated cases, palpitations or arrhythmias. Therefore, the drug should be administered slowly. From the gastrointestinal tract rarely - loss of appetite, dyspepsia, diarrhea, constipation, nausea and vomiting. From the CNS and peripheral nervous system in rare cases, the alleged effect of activation was accompanied by agitation (manifested aggressive behavior, confusion, insomnia).There are reports of occurrence in isolated cases. From the immune system it is extremely rare - hypersensitivity reactions or allergic reactions, manifested by headache, pain in the neck, limbs, lower back, shortness of breath, chills and collaptoid state. Local reactions rarely - redness of the skin , itching and burning at the injection site. Others are extremely rare - according to the results of studies, cases of hyperventilation, hypertension, hypotension, fatigue, tremor, depression, apathy, were reported. dizziness and flu-like symptoms (cough, runny nose, respiratory tract infections). It should be noted that some adverse effects (agitation, arterial hypertension, arterial hypotension, lethargy, tremor, depression, apathy, dizziness, headache, shortness of breath, diarrhea, nausea) were identified during clinical trials and occurred equally in patients treated with Cerebrolysin and in patients of the placebo group.

Overdose

Currently, cases of an overdose of the drug Cerebrolysin were reported.

Interaction with other drugs

With the simultaneous use of Cerebrolysin with antidepressants or MAO inhibitors, mutual enhancement of their action is possible. In such cases, it is recommended to reduce the dose of antidepressant. Pharmaceutical interaction: Cerebrolysin is incompatible with solutions containing lipids and with solutions that change the pH of the medium (5.0-8.0).

special instructions

After opening the ampoule / vial Cerebrolysin solution should be used immediately. If the injection is too fast, you may feel hot, sweating, dizziness. Therefore, the drug should be administered slowly. Compatibility of the drug was tested and confirmed (within 24 hours at room temperature and the presence of light) with the following standard solutions for infusions: 0.9% sodium chloride solution, Ringer's solution, 5% dextrose (glucose) solution. The simultaneous use of Cerebrolysin with vitamins and drugs that improve cardiac circulation is allowed, but these drugs should not be mixed in the same syringe with Cerebrolysin. Do not mix in one solution for infusion Cerebrolysin and balanced solutions of amino acids.You should use only a clear solution of Cerebrolysin and only once. Impact on the ability to drive motor vehicles and control mechanisms: Clinical trials have shown that Cerebrolysin does not affect the ability to drive vehicles and the use of mechanisms.

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