Cerebrolysin injection solution ampoules 5 ml 5 pcs
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Release form
Solution
Composition
Active ingredient: Cerebrolysin concentrate (a complex of peptides derived from the brain of a pig) 215, 2 mg
Pharmacological effect
Nootropic drug. Cerebrolysin contains low molecular weight biologically active neuropeptides that penetrate the BBB and directly reach the nerve cells. The drug has an organ-specific multimodal effect on the brain, i.e. provides metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity. Metabolic regulation: the drug Cerebrolysin increases the efficiency of the brain's aerobic energy metabolism, improves intracellular protein synthesis in the developing and aging brain. increases survival and prevents neuron death under hypoxia, and and It reduces the damaging neurotoxic effect of excitatory amino acids (glutamate). Neurotrophic activity: the drug Cerebrolysin is the only nootropic peptidergic drug with proven neurotrophic activity, similar to the action of natural neuronal growth factors (NGF), but manifested in conditions of peripheral administration. impact on cognitive impairment on memory processes.
Pharmacokinetics
The complex composition of Cerebrolysin, the active fraction of which consists of a balanced and stable mixture of biologically active oligopeptides with a total polyfunctional effect, does not allow for the usual pharmacokinetic analysis of individual components.
Indications
Alzheimer's disease; dementia syndrome of various origins; chronic cerebrovascular insufficiency; ischemic stroke; traumatic injuries of the brain and spinal cord; mental retardation in children; hyperactivity and attention deficit in children; in complex therapy for endogenous depression resistant to antidepressants.
Contraindications
Individual intolerance to the drug; acute renal failure; epileptic status.
Precautionary measures
After opening the ampoule / vial Cerebrolysin solution should be used immediately.
Use during pregnancy and lactation
Caution should be used Cerebrolysin in the first trimester of pregnancy and lactation. Use of the drug during pregnancy and during breastfeeding is possible only when the intended benefit to the mother outweighs the potential risk to the fetus / newborn. The results of experimental studies provide no grounds for believing Cerebrolysin has a teratogenic effect or has a toxic effect on the fetus. However, similar clinical studies have not been conducted.
Dosage and administration
V / m (up to 5 ml), iv (up to 10 ml), iv, by slow infusion (from 10 to 50 ml). Doses and duration of treatment depend on the nature and severity of the disease, as well as on the age of the patient. You can assign single doses, the value of which can reach 50 ml, but more preferably a course of treatment. The recommended optimal course of treatment is daily injections for 10–20 days. Acute conditions (ischemic stroke, TBI, complications after neurosurgical operations) - from 10 to 50 ml. The normal period of cerebral stroke and traumatic damage to the brain and spinal cord is from 5 to 50. ml. Psychoorganic syndrome and depression - from 5 to 30 ml. Alzheimer's disease, dementia of vascular and combined alzheimerov-vascular genesis - from 5 to 30 ml. In neuropediatric practice - 0.1–0.2 ml / kg. To increase the effectiveness of treatment can provo repeat courses, as long as there is an improvement in the patient's condition due to treatment. After the first course, the frequency of doses can be reduced to 2 or 3 times a week. It is recommended to administer doses from 10 to 50 ml only by means of slow intravenous infusions after dilution with the proposed standard solutions for infusions. The duration of infusions is from 15 to 60 minutes.
Side effects
Reaction to rapid administration: with excessively rapid administration, in rare cases, a sensation of heat, sweating, dizziness is possible; in isolated cases - possible heart palpitations or arrhythmias. Therefore, the drug should be administered slowly. For the gastrointestinal tract: rarely - loss of appetite, dyspepsia, diarrhea, constipation, nausea and vomiting. ).There are reports of the occurrence in isolated cases (<0.01%) of large epileptic seizures and convulsions during treatment with Cerebrolysin. On the immune system: extremely rare - hypersensitivity reactions or allergic reactions, manifested by headache, pain in the neck, limbs , lower back, shortness of breath, chills and a collaptoid state. Local reactions: rarely - redness of the skin, itching and burning at the injection site. Others: extremely rare - cases of hyperventilation have been reported from research results arterial hypertension, hypotension, fatigue, tremor, depression, apathy, dizziness, and flu-like symptoms (cough, runny nose, respiratory tract infections). It should be noted that some undesirable effects (agitation, hypertension, arterial hypotension, lethargy, tremor, depression, apathy, dizziness, headache, shortness of breath, diarrhea, nausea) were detected during clinical trials and occurred equally in patients treated with Cerebrolysin and patients in the placebo group.
Overdose
Currently, cases of an overdose of the drug Cerebrolysin were reported.
Interaction with other drugs
With the simultaneous use of Cerebrolysin with antidepressants or MAO inhibitors, mutual enhancement of their action is possible. In such cases, it is recommended to reduce the dose of the antidepressant. Pharmaceutical interaction Cerebrolysin is incompatible with solutions containing lipids and with solutions that change the pH of the medium (5.0-8.0).
special instructions
If the injection is too fast, you may feel hot, sweating, dizziness. Therefore, the drug should be administered slowly. The compatibility of the drug (for 24 hours at room temperature and light) with the following standard solutions for infusions is checked and confirmed: 0.9% sodium chloride solution, Ringer's solution, 5% dextrose (glucose) solution. Simultaneous use is allowed Cerebrolysin with vitamins and drugs that improve cardiac blood circulation, however, these drugs should not be mixed in the same syringe with Cerebrolysin. Do not mix in one solution for infusion Cerebrolysin and sbal nsirovannye solutions aminokislot.Sleduet only use transparent Cere solution and only odnokratno.Vliyanie on ability to drive vehicles and management mehanizmamiKlinicheskie tests showedthat Cerebrolysin does not affect the ability to drive and use mechanisms.