Chlorprothixene 15 pills 30 pcs
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Active ingredients
Chlorprothixen
Release form
Pills
Composition
Active ingredient: Chlorprothixene (Chlorprothixenum) Active ingredient concentration (mg): 15
Pharmacological effect
Antipsychotic (neuroleptic), a derivative of thioxanthene. has antipsychotic, antidepressant, sedative, antiemetic effects, has alpha-adreno-blocking activity. It is believed that antipsychotic action is associated with the blockade of postsynaptic dopamine receptors in the brain. the antiemetic effect is associated with blockade of the chemoreceptor trigger point of the medulla oblongata. sedative effect due to the indirect weakening of the activity of the reticular system of the brain stem. inhibits the release of most hormones of the hypothalamus and pituitary. However, as a result of blockade of the prolactin inhibitory factor, which inhibits the release of prolactin from the pituitary, prolactin concentration increases. The chemical structure and pharmacological properties of thioxanthenes are similar to piperazine derivatives of phenothiazine.
Pharmacokinetics
Metabolized in the liver. Excreted mainly by the kidneys.
Indications
Chlorprothixene is a sedative neuroleptic with a wide range of indications, which include: psychosis, including schizophrenia and manic states, occurring with psychomotor agitation, agitation and anxiety, hangover withdrawal syndrome during childhood, alcoholism and drug addiction, hyperactivity, irritability, arousal, mentality, adult, mental illness, alcoholism and drug addiction; behavioral disorders in children; depression, neurosis, psychosomatic disorders; insomnia; pain (in combination with analgesics).
Contraindications
depression of the central nervous system of any origin (including those caused by alcohol, barbiturates or opiates), coma, vascular collapse, diseases of the blood-forming organs, pheochromocytoma, hypersensitivity to the components of Chlorprothixene.
Precautionary measures
Keep out of the reach of children.
Use during pregnancy and lactation
Contraindicated for use during pregnancy and lactation.
Dosage and administration
Chlorprothixene take inside.Dose, frequency and duration of use are set individually. The average daily dose, divided into 2-3 doses, is 500 mg.
Side effects
Drowsiness, tachycardia, dry mouth, excessive sweating, difficulty of accommodation. These side effects, usually occurring at the beginning of therapy, often disappear as it continues. Orthostatic hypotension may occur, especially with the use of Chlorprotixen in high dosages. Headache, dysmenorrhea, skin rashes, and constipation are rare. Extrapyramidal symptoms are especially rare. Isolated cases of reduced seizure threshold, transient benign leukopenia and hemolytic anemia are described. With prolonged use, especially in high doses, cholestatic jaundice, galactorrhea, and appetite may occur. body mass.
Interaction with other drugs
With simultaneous use with anesthetics, opioid analgesics, sedatives, hypnotic drugs, anti-psychotic opticians, with ethanol, ethanol-containing drugs, the inhibitory effect on the CNS is enhanced. action.When used simultaneously with agents that cause extras iramide reactions, possible increase in the frequency and severity of extrapyramidal reactions; with levodopa - suppression of anti-parkinsonian action of levodopa is possible; with lithium carbonate - pronounced extrapyramidal symptoms, neurotoxic effect are possible. If used concurrently with epinephrine, blockade of alpha-adrenergic effects of epinephrine and the development of severe arterial hypotension and tachycardia as a result of this can occur. with quinidine - possibly strengthening the inhibitory effect on the heart.
special instructions
Should not be used for epilepsy, a tendency to collapse, parkinsonism, heart defects in the stage of decompensation,tachycardias, cerebral vascular atherosclerosis, pronounced impaired liver and kidney function, hematopoietic disorders, cachexia, in the elderly. hypotension), Reye's syndrome, as well as glaucoma or predisposition to it, gastric ulcer and duodenal ulcer, urinary retention, Parkinson’s disease, e pyleptic seizures, hypersensitivity to other thioxanthenes or fenothiazines mechanisms during the period of treatment should refrain from engaging in potentially hazardous activities requiring increased attention, rapid psychomotor reactions.