Cortexin lyophilisate for preparation of a solution for intramuscular injection of 10 mg vials of 10 pcs.
Condition: New product
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Active ingredients
Cattle Bark Polypeptides
Release form
Powder
Composition
Active ingredient: Cortexin (Cortexin) Active ingredient concentration (mg): 10
Pharmacological effect
Nootropic drug. Contains a complex of low molecular weight water-soluble polypeptide fractions with a molecular weight of not more than 10,000 Da. It penetrates the BBB directly to the nerve cells. The drug has a nootropic, neuroprotective, antioxidant and tissue-specific effect. Neurotropic action Improves higher brain functions, learning and memory processes, concentration, resistance to various stress effects. , reduces the toxic effects of psychotropic substances. Antioxidant effectInhibits lipid peroxidation in non Yronah, increases neuronal survival under conditions of oxidative stress and hypoxia. Tissue-specific action activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, improves the function of the cerebral cortex and the overall tone of the nervous system. The mechanism of action ; optimizing the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABA-ergic effect; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectric activity; preventing the formation of free radicals (lipid peroxidation products).
Pharmacokinetics
The composition of the drug Cortexin, the active ingredient of which is a complex of polypeptide fractions, does not allow the usual pharmacokinetic analysis of individual components.
Indications
In the complex therapy of cerebral circulation disorders, craniocerebral trauma and its consequences, encephalopathies of various origins, cognitive impairments (memory and thinking disorders), acute and chronic encephalitis and encephalomyelitis, epilepsy, asthenic conditions (supersegmental autonomic disorders)reduced ability to learn, delayed psychomotor and speech development in children, various forms of cerebral palsy.
Contraindications
Individual intolerance to the drug.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy (due to the lack of data from clinical studies). If necessary, the use of the drug during lactation should stop breastfeeding (due to lack of data from clinical studies).
Dosage and administration
Before injection, the contents of the vial are dissolved in 1-2 ml of a 0.5% solution of procain (novocaine), water for injection or a 0.9% solution, sodium chloride and administered once daily: to adults at a dose of 10 mg for 10 days; children with body weight up to 20 kg at a dose of 0.5 mg / kg, with a body weight of more than 20 kg - at a dose of 10 mg for 10 days. If necessary, repeat the course in 3-6 months.
Side effects
No adverse events reported. Individual hypersensitivity to the drug components is possible.
Overdose
Currently, no cases of overdose have been reported.
Interaction with other drugs
Drug interaction of the drug Cortexin is not described.
special instructions
Cortexin should be used only in accordance with the doctor's prescription. The bottle with the dissolved drug should not be stored and used after storage. Cortexin solution is not recommended to be mixed with other solutions. There are no particular features of the drug when first injected or discontinued. In case of missing the injection, it is not recommended to inject a double dose, but to carry out the next injection as usual on the scheduled day. Special precautions when eliminating unused medicinal drugs are not required. Impact on the ability to drive vehicles and control mechanisms. The use of the drug does not affect the performance of about hazardous activities that require special attention and quick reactions (driving, working with moving machinery).