Dicinone injection 250mg 2ml ampoules 2ml N50
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Active ingredients
Etamzilat
Release form
Solution
Composition
1 ampoule contains: etamzilat 250 mg. Auxiliary substances: sodium disulfite, water d / i, sodium bicarbonate (used in some cases for pH correction).
Pharmacological effect
Hemostatic drug. The drug increases the formation of large molecular weight mucopolysaccharides in the capillary walls and increases the stability of capillaries, normalizes their permeability during pathological processes, improves microcirculation. It has a hemostatic effect, which is caused by the activation of the formation of thromboplastin at the site of damage to small vessels. The drug stimulates the formation of coagulation factor III, normalizes the adhesion of platelets. The drug does not affect the prothrombin time, does not possess hypercoagulative properties and does not contribute to the formation of blood clots. After intravenous administration, the drug begins to act after 5-15 minutes; the maximum effect is observed after 1 hour, the duration of action is 4-6 hours.
Pharmacokinetics
Absorption and distribution After i / v administration of the drug at a dose of 500 mg Cmax is reached after 10 minutes and is 50 μg / ml. After ingestion, the drug is rapidly and almost completely absorbed. After taking the drug in a dose of 50 mg Cmax is reached after 4 hours and is 15 μg / ml. Etamzilat penetrates the placental barrier and is excreted in breast milk. Excretion About 72% of the administered dose is eliminated by the kidneys during the first 24 hours in an unchanged form. in the introduction of T1 / 2 is about 2 hours, after ingestion of T1 / 2 is about 8 hours
Indications
Prevention and treatment of capillary hemorrhages of various etiologies: during and after surgical operations on all well vascularized tissues in otolaryngology, gynecology, obstetrics, urology, dentistry, ophthalmology and plastic surgery; hematuria, metrorrhagia, primary menorrhagia, menorrhagia in women with intrauterine contraceptives, nasal bleeding, gingival bleeding; diabetic microangiopathy (hemorrhagic diabetic retinopathy, recurrent hemorrhages in the retina, hemophthalmus); intracranial hemorrhage in newborns and premature babies.
Contraindications
Acute porphyria; hemoblastosis in children (lymphoblastic and myeloblastic leukemia, osteosarcoma); thrombosis; thromboembolism; hypersensitivity to the components of the drug and sodium sulfite; hypersensitivity to sodium sulfite (solution for IV and IM injection).
Precautionary measures
With caution should be prescribed the drug for thrombosis, thromboembolism in history, bleeding in the background of an overdose of anticoagulants.
Use during pregnancy and lactation
Use during pregnancy is possible only in cases where the potential benefit of therapy for the mother outweighs the possible risk to the fetus. If you need to take a drug during lactation, you should decide whether to stop breastfeeding.
Dosage and administration
The optimal daily dose for adults is 10–20 mg / kg, divided into 3–4 intramuscular or intravenous (slow) injections. Prophylactically, adults in surgical interventions are injected intramuscularly or intramuscularly with 250–500 mg per 1 hour. before surgery. During the operation, 250-500 mg are administered intravenously; the introduction of this dose can be repeated once more. After the operation, 250-500 mg is administered every 6 hours until the risk of bleeding is eliminated. For children, the daily dose is 10-15 mg / kg body weight, divided into 3-4 injections. In neonatology: Dicynone administered in / m or / in ( slowly) at a dose of 12.5 mg / kg (0.1 ml = 12.5 mg). Treatment should begin within the first 2 hours after birth. If Dysinone is mixed with saline, it should be injected immediately.
Side effects
On the part of the central nervous system and peripheral nervous system: headache, dizziness, paresthesia of the lower extremities. On the part of the digestive system: nausea, heartburn, heaviness in the epigastric region. Others: allergic reactions, flushing of the skin, reduction of systolic blood pressure.
Overdose
Data overdose Dicynone not provided.
Interaction with other drugs
The introduction of a dose of 10 mg / kg body weight for 1 hour before the introduction of dextrans prevents their antiplatelet effect. The administration of Dicionone after administration of dextran does not have a hemostatic effect. It is possible to combine with aminocaproic acid and sodium menadione bisulfite.
special instructions
The solution for i / m and i / v injections can be applied topically: a sterile swab or gauze cloth is impregnated with a solution and applied to the wound (for example, skin graft, tooth extraction). Effect on the ability to drive vehicles and control mechanisms. No special precautions are required.