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Active ingredients
Mometasone
Release form
Cream
Composition
Active ingredient: MometasoneActivities: hexyleneglycol, purified water, phosphoric acid (for setting the straw marshmallower), propylene glycol stearate, stearyl alcohol and macrogol cetostearate (Ceteareth-20), titanium dioxide, aluminum starch octenylsuccinate, beeswax white straw, white bee wax, white honey beehive. mg): 1 mg
Pharmacological effect
Gx for external use. It has anti-inflammatory, antipruritic and antiexudative effects. CGs induce the release of proteins that inhibit phospholipase a2 and commonly known as lipocortins, which control the biosynthesis of inflammatory mediators such as prostaglandins and leukotrienes, by inhibiting the release of their common precursor, arachidonic acid.
Pharmacokinetics
Drug absorption by external administration is negligible. 8 h after application to intact skin (without an occlusive dressing), 0.7% of mometasone is detected in the systemic circulation.
Indications
Inflammation and pruritus in dermatoses, susceptible to glucocorticosteroid therapy
Contraindications
Hypersensitivity to any component of the drug or to GCS. Pink acne, perioral dermatitis. Bacterial, viral (Herpes simplex, chicken pox, Herpes zoster) or a fungal infection of the skin. Tuberculosis, syphilis. Posvaccinal reactions. Pregnancy (treatment of large areas of skin, long-term treatment). Lactation period (use in large doses or / and for a long time).
Precautionary measures
The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.
Use during pregnancy and lactation
The safety of using mometasone furoate during pregnancy and lactation has not been studied. HCS penetrate the placental barrier. Long-term treatment and use in high doses during pregnancy should be avoided due to the risk of negative effects on the development of the fetus. GCS are excreted in breast milk. If you need to use GCS in high doses and / or for a long time, you should stop breastfeeding.
Dosage and administration
Outer. A thin layer of cream or ointment Elocom is applied to the affected skin once a day. The duration of the course of treatment is determined by its effectiveness, as well as by the tolerance of the patient, the presence and severity of side effects.
Side effects
Rarely - irritation and dryness of the skin, burning sensation, itching, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, the attachment of a secondary infection, signs of skin atrophy, stretch marks, prickly pears. In less than 1% of cases - the formation of papules, pustules. When using external forms of GCS for a long time and / or to treat large areas of the skin, or using occlusive dressings, especially in children and adolescents, side effects typical of GCS may occur. systemic action, including adrenal insufficiency and Cushing syndrome.
Overdose
Symptoms: suppression of the hypothalamic-pituitary-adrenal system, including secondary adrenal insufficiency. Treatment: symptomatic, if necessary - correction of electrolyte imbalance, drug withdrawal (with long-term therapy - gradual cancellation).
Interaction with other drugs
No interaction of the drug Elocom with other drugs is not registered.
special instructions
When applied on large areas of the skin for a long time, especially when using occlusive dressings, the development of systemic action of the SCS is possible. Given this, patients should be observed to identify signs of suppression of the hypothalamic-pituitary-adrenal system and the development of Cushing's syndrome. Avoid contact with the eyes. The composition of Elocom ointment includes propylene glycol stearate, which can cause irritation at the site of application. In such cases, you should stop using the drug and prescribe the appropriate treatment. It should be borne in mind that GCS can alter the manifestations of certain skin diseases, which can make the diagnosis difficult. In addition, the use of corticosteroids may cause delayed wound healing. In case of long-term cure of corticosteroids, a sudden cessation of therapy can lead to the development of rebound syndrome, manifested in the form of dermatitis with intense reddening of the skin and burning sensation.Therefore, after a long course of treatment, the drug should be discontinued gradually, for example, switching to an intermittent treatment regimen before it is completely stopped. Any of the side effects described with systemic use of GCS, including suppression of adrenal function, can also occur with topical administration, especially in children. Use in pediatricsIn connection with the fact that in children the magnitude of the ratio of surface area and body weight is greater than in adults, children are at greater risk of suppressing hypothalamus function mo-pituitary-adrenal system and the development of Cushing's syndrome when using any GCS local action. Prolonged use of GCS in children can lead to impaired growth and development. Children should be given a minimum dose of the drug sufficient to achieve the effect. Effect on the ability to drive motor vehicles and control mechanismsThe effect of the drug Elocom on the ability to drive vehicles or moving mechanisms is not marked.