Enterofuryl capsules 100 mg 30 pcs
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Active ingredients
Nifuroxazide
Release form
Capsules
Composition
Active ingredient: Nifuroksazid (Nifuroxazide) Concentration of active ingredient (mg): 100
Pharmacological effect
Antimicrobial drug of a broad spectrum, a derivative of 5-nitrofuran. It is assumed that the antimicrobial activity of nifuroxazide is due to the presence of the NO2 group in its composition, which causes inhibition of dehydrogenase activity and disrupts protein synthesis in pathogenic bacteria. Gram-negative enterobacteria: Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp., Enterobacter spp., Vibrio cholerae, Campylobacter jejuni, Edwarsiella spp., Citrobacter spp., Yocinia sj., Citrobacter spp., Yocinia sj., Citrobacter spp., Citrobacter spp., Citrobacter spp., Citrobacter spp., Shigella spp. normal intestinal flora. When acute bacterial diarrhea restores intestinal eubiosis. When infected with enterotropic viruses prevents the development of bacterial superinfection.
Pharmacokinetics
After taking the drug inside nifuroksazid almost not absorbed from the gastrointestinal tract and shows its antibacterial effect exclusively in the intestinal lumen. Fully excreted in the feces. The rate of excretion depends on both the dose and intestinal motility.
Indications
Diarrhea of bacterial genesis.
Contraindications
1. Hypersensitivity to nitrofuran derivatives or other components of the drug. Children's age up to 3 years (for this dosage form) .3. Fructose intolerance, glucose-galactose malabsorption syndrome, sucrase and isomaltase deficiency.
Precautionary measures
During therapy with Enterofuryl, the use of alcohol is prohibited. it increases the body's sensitivity to nifuroxazide. When treating diarrhea, simultaneously with therapy with Enterofuryl, it is necessary to conduct rehydration therapy (oral or IV) in accordance with the patient's condition and the intensity of diarrhea.
Use during pregnancy and lactation
Use of the drug Enterofuryl during pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus. Enterofuryl is not absorbed from the gastrointestinal tract and does not enter the systemic circulation. The use of the drug during lactation is possible only under strict indications, and the issue of discontinuing breastfeeding should be resolved.
Dosage and administration
It is used inside. Capsules 100 mg: Adults and children over 7 years old: 2 capsules x 4 times a day (200 mg x 4 times a day, only 800 mg nifuroxazide / day) Children 3 - 7 years: 2 capsules x 3 times per day (200 mg x 3 times a day, only 600 mg nifuroxazide / day)
Side effects
Nausea, vomiting, allergic reactions (rash, urticaria, angioedema, anaphylactic shock).
Overdose
The drug is not absorbed from the gastrointestinal tract and does not enter the systemic circulation. Overdose symptoms are unknown. Treatment: if the dose is exceeded, gastric lavage and symptomatic therapy are recommended.
Interaction with other drugs
There is no evidence that nifuroxazide interacts with other drugs.
special instructions
If symptoms of hypersensitivity appear (dyspnea, rash, itching), the drug should be discontinued. Before the drug is prescribed, patients (including infants) should be excluded from congenital deficiency of enzymes that break down sucrose. does not affect the psychomotor activity and ability to drive vehicles and work with mechanisms.