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Active ingredients
Fenspirid
Release form
Syrup
Composition
Active ingredient: Fenspiride (Fenspiride) Active ingredient concentration (mg): 200 mg
Pharmacological effect
Anti-inflammatory agent, has antiexudative effect, prevents the development of bronchospasm. Shows antagonism with mediators of inflammation and allergy: serotonin, histamine (blockade of H1-histamine receptors), bradykinin. It has an antispasmodic myotorotic effect. When administered in large doses, it reduces the production of various inflammatory factors (cytokines, arachidonic acid derivatives, free radicals).
Pharmacokinetics
Suction Well absorbed from the digestive tract. After ingestion, Cmax is reached in 2.3 ± 2.5 hours (from 0.5 to 8 hours). Excretion of T1 / 2 is 12 hours. It is mainly excreted by the kidneys (90%), through the intestine 10%.
Indications
Diseases of the upper and lower respiratory tract: Ninopharyngitis and laryngitis; Tracheobronchitis; Bronchitis (with or without chronic respiratory failure); Bronchial asthma (as part of complex therapy); Respiratory phenomena (cough, hoarseness, sore throat) for measles, whooping cough and flu; In infectious diseases of the respiratory tract, accompanied by cough, when shown standard antibiotic therapy. Otitis and sinusitis of various etiologies.
Contraindications
Hypersensitivity to the active substance and / or any of the components of the drug. Children age up to 2 years.
Use during pregnancy and lactation
Data on the use of the drug Erespal in pregnant women are missing or limited. The use of the drug during pregnancy is not recommended. Fenspiride therapy is not a reason to terminate the pregnancy. Erespal should not be used during breastfeeding due to the lack of data on the penetration of fenspiride into breast milk.
Dosage and administration
Inside Shake before use. Adults and adolescents: From 3 to 6 tablespoons of syrup (45 - 90 ml) per day, taken before meals. Children from 2 years: The recommended dose of 4 mg / kg / day. body weight up to 10 kg: from 2 to 4 teaspoons of syrup per day (or 10 to 20 ml); you can add to a bottle of food more than 10 kg body weight: from 2 to 4 tablespoons of syrup per day (or 30 to 60 ml ), take before a meal 1 tablespoon (15 ml of syrup) contains 30 mg of fenspirid hydrochloride and 9 g of sucrose. 1 teaspoon (5 ml of syrup) contains 10 mg of fenspiride hydrochloride and 3 g of sucrose.
Side effects
Since the cardiovascular system Rarely: moderate tachycardia, the severity of which decreases with decreasing the dose of the drug. Digestive system Often: gastrointestinal disorders, nausea, epigastric pain. Unspecified frequency: diarrhea, vomiting. From the side of the central nervous system Rarely: drowsiness. Unset frequency: dizziness. General disorders and symptoms Unassigned frequency: asthenia, increased fatigue. On the part of the skin and subcutaneous fat Rarely: erythema, rash, urticaria, angioedema, fixed pigment erythema. Unset frequency: pruritus. The risk of development of hypersensitivity reactions to Sunset dye yellow S, which is part of the preparation.
Overdose
In case of overdose (overdose cases are noted when taking the drug in a dose of more than 2320 mg), the patient should immediately seek medical help. Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia. Treatment: gastric lavage, ECG monitoring, maintenance of vital body functions .
Interaction with other drugs
Special studies on the interaction of fenspiride with other drugs have not been carried out. Because of the possible sedative effect when taking histamine H1 receptor blockers, the use of Erespal syrup in combination with drugs that have a sedative effect, or together with alcohol is not recommended.
special instructions
The preparation in the form of a syrup includes parabens (parahydroxybenzoates), as a result, taking this drug can provoke the development of allergic reactions, including deferred.When prescribing a drug to patients with diabetes, it is necessary to take into account that Erespal syrup contains sucrose (1 teaspoon - 3 g sucrose = 0.3 XE; 1 tablespoon - 9 g sucrose = 0.9 XE). Influence on ability to drive motor vehicles and control mechanisms Research to study the effect of the drug Erespal on the ability to drive vehicles and work with mechanisms was not carried out. Patients should be aware of the possible development of drowsiness when taking the drug Erespal, especially at the beginning of therapy or when combined with alcohol, and should be careful when driving vehicles and when performing work that requires high speed psychomotor reactions.