Ferretable capsules with prolonged action N30
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Active ingredients
Iron fumarate + folic acid
Release form
Capsules
Composition
1 capsule contains: Active substance: iron fumarate 163.56 mg, equivalent to 152.1 mg of dry matter, equivalent to 50 mg of iron, folic acid (Vit. Bc) 540 μg, equivalent to 500 μg of dry substance. Supplemental substances: mini-tablet of iron fumarate: lactose monohydrate - 3.42 mg, colloidal silicon dioxide - 600 mcg, magnesium stearate - 600 mcg, copolymer of methyl methacrylate and ethyl acrylate (2: 1) - 4.66 mg; minipills folic acid: lactose monohydrate - 24.21 mg, Microcrystalline Cellulose - 24.25 mg Colloidal silica - 500 mg magnesium stearate - 500 mkg.Sostav capsule shell: Gelatin - 36.4804 mg dye azorubin - 74.2 ug, quinoline yellow dye - 148.4 mcg , titanium dioxide - 496 mcg. The composition of the capsule cap: gelatin - 24.3203 mg, azorubine dye - 49.8 mcg, quinoline yellow dye - 99.6 mcg, titanium dioxide - 330.3 mcg.
Pharmacological effect
Combined antianemic drug, the action of which is due to the properties of the components included in its composition. The iron fumarate is an iron salt, a trace element necessary for the synthesis of hemoglobin. When using iron in the form of salts, there is a rapid replenishment of its deficiency in the body, which leads to a gradual regression of clinical (weakness, fatigue, dizziness, tachycardia, soreness and dryness of the skin) and laboratory symptoms of anemia. Folic acid is necessary for normal maturation of megaloblasts and the formation of normoblasts. Stimulates erythropoiesis, is involved in the synthesis of amino acids, nucleic acids, purines and pyrimidines, in the metabolism of choline. When pregnancy protects the body from the action of teratogenic factors. Ferretab comp. helps to maintain and restore normal levels of iron in the blood. Prevents anemia (including during pregnancy), miscarriage, premature birth and impaired mental development of the child, which can occur with iron deficiency and folic acid in the body. The amount of digestible iron varies between 5% and 35%. In serum, iron binds to transferrin and is involved in the formation of hemoglobin, myoglobin, cytochrome oxidase, catalase and peroxidase, or is deposited in the body's tissues in the form of ferritin.
Pharmacokinetics
Absorption and distribution Folic acid is absorbed mainly from the upper gastrointestinal tract (duodenum); Plasma protein binding is 64%. Metabolism and excretion Iron excretion occurs with feces, urine, and sweat. Folic acid is metabolized in the liver and is excreted mainly by the kidneys, and also partially with feces.
Indications
Treatment and prevention of iron deficiency states: - during pregnancy; - due to impaired absorption of iron from the gastrointestinal tract; - due to prolonged bleeding; - due to unbalanced and inadequate nutrition.
Contraindications
- diseases associated with the accumulation of iron in the body (aplastic and hemolytic anemia, thalassemia, hemosiderosis, hemochromatosis); disorders of iron absorption (sideroachrestric anemia, lead anemia, pernicious anemia / vitamin B12 / deficiency); - anemia not associated with iron deficiency or folic acid; - hypersensitivity to the drug.
Use during pregnancy and lactation
Perhaps the use of the drug Ferretab comp. during pregnancy and lactation (breastfeeding) according to indications.
Dosage and administration
The drug is prescribed in 1 caps / day. With a pronounced deficiency of iron or folic acid, the dose is increased to 2-3 caps / day. Maintenance therapy should continue for at least 4 weeks after reaching a normal hemoglobin level to normalize serum ferritin, reflecting iron stores in the body. The drug should be taken on an empty stomach, drinking plenty of fluids.
Side effects
On the part of the digestive system: in some cases - a feeling of fullness in the stomach, discomfort, nausea, vomiting. Others: allergic reactions. The drug is usually well tolerated.
Overdose
Symptoms: may increase the manifestations of the described side effects. Treatment: first of all, it is necessary to determine the content of iron and ferritin in serum. If the serum ferritin content is significantly exceeded in the serum, deferoxamine is prescribed in accordance with the dose recommended by the manufacturer.
Interaction with other drugs
With simultaneous use of the drug Ferretab comp.with antacids, iron absorption deteriorates. Simultaneous intake with ascorbic acid helps to improve iron absorption. With simultaneous use of Ferretab comp. with ascorbic acid, iron absorption is improved. With the combined use of tetracycline antibiotics and Ferretab; comp. iron absorption is impaired (this combination should be avoided). Colestiramine, phenytoin, phenobarbital, carbamazepine, sulfasalazine, hormonal contraceptives, folic acid antagonists, trimethoprim, triamterene, solid food, bread, raw cereals, dairy products, eggs, reduce absorption of iron.
special instructions
Before starting drug therapy, it is necessary to determine the content of iron and ferritin in the serum (that is, to document iron deficiency). Therapy with Ferretab Comp. should be carried out before normalization of the blood picture (8-12 weeks). When using the drug, darker feces are possible. Against the background of the use of the drug, a false-positive result of the benzidine test may be obtained.