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Active ingredients
Aluminum hydroxide-magnesium carbonate gel + magnesium hydroxide
Release form
Pills
Composition
Active ingredient: Aluminum hydroxide-magnesium carbonate gel, Magnesium hydroxide (Magnesium hydroxide) Concentration of the active substance (mg): 750
Pharmacological effect
Combined antacid. reduces the acidity of gastric juice and does not have a stimulating effect on the secretion of gastric juice. aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after ingestion) and prolonged (about 2 hours) neutralization of hydrochloric acid of the gastric juice, while maintaining gastric acidity at the physiological level (ph 3-5). 1 tablet of the drug gastal neutralizes about 21.5 mmol of hydrochloric acid. Gastal inhibits the action of pepsin, lysolecithin and bile acids, eliminates dyspeptic phenomena. enhances protective and regenerative processes in the gastric mucosa. aluminum ions have a cytoprotective effect due to increased secretion of mucin and sodium bicarbonate, activation of prostaglandin e2 and no, accumulation of epidermal growth factor at the site of damage to the mucous membrane, and an increase in the concentration of phospholipids in the stomach wall.
Pharmacokinetics
Gastal has no systemic effect in patients with normal kidney function. After interacting with hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline environment of the intestine and excretes as insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in the gastric juice with the formation of magnesium chloride, which has osmotic properties and a mild laxative effect, which neutralizes the anchoring effect of aluminum hydroxide in the small intestine. Magnesium is excreted in the form of insoluble carbonate.
Indications
Dyspeptic symptoms such as discomfort or pain in the epigastrium, heartburn, acid regurgitation after errors in diet, excessive use of ethanol, coffee, nicotine, dyspeptic symptoms such as discomfort or pain in the epigastrium, heartburn, acidic belching (and their prevention) as a result of the use of certain drugs (NSAIDs, GCS), conditions accompanied by increased acid production: gastric ulcer, gastritis, reflux esophagitis; hiatal hernia.
Contraindications
Hypersensitivity to aluminum salts, magnesium or other components of the drug, severe renal failure, Alzheimer's disease, hypophosphatemia, lactose intolerance, lactase deficiency or glucose-galactose malabsorption, children under 6 years of age. With caution: in chronic renal failure (CRF), pregnancy and during the breastfeeding period, adults and children over 12 years old with a body weight of less than 50 kg, children from 6 to 12 years old, and older.
Precautionary measures
The drug should be stored out of the reach of children at a temperature not higher than 25 ° C.
Use during pregnancy and lactation
The use of the drug during pregnancy and lactation (breastfeeding) is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus. Gastal is not excreted in breast milk.
Dosage and administration
Inside, gradually dissolving in the mouth. Adults and children over 12 years old with a body weight of at least 50 kg: 1-2 pills 4-6 times a day approximately 1 hour after meals and at bedtime, but not more than 8 pills per day . The duration of treatment is not more than 2 weeks. Similar doses are recommended for the treatment of heartburn regardless of food intake. Adults and children over 12 years old with a body weight less than 50 kg, children aged 6 to 12 years: The dose is half the recommended dose for adults. The duration of treatment is no more than 2 weeks. Patients with CKD dose adjustment is not required.
Side effects
When using the drug in recommended doses, adverse reactions are rare (at least 0.01%, but less than 0.1%): nausea, constipation, diarrhea, change in taste. In exceptional cases, allergic reactions are possible.
Overdose
Symptoms of acute overdose are not described. Symptoms: with prolonged high doses of drugs containing aluminum and magnesium, hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagneemia, hyperaluminemia, encephalopathy, nephrocalcinosis, and a unit and a nephrocalcinosis will be developed. Possible increased side effects from the digestive system (constipation, diarrhea). In patients with renal insufficiency, thirst, a decrease in blood pressure, and hyporeflexia are possible. Treatment: symptomatic therapy.
Interaction with other drugs
Gastal while the use of levodopa and enhances the activity of nalidixic acid and reduces delays absorption quinolones, isoniazid, naproxen, iron preparations, indomethacin, chlorpromazine, beta-blockers, diflunisal, histamine H2 receptor, fat-soluble vitamins, anticoagulants, interaction barbituratov.Pri with metal ions included in antacids, tetracyclines form insoluble chelate complexes; As a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. Simultaneous administration of these drugs is not possible. If necessary, the combined use of tetracycline should be taken at least 2 hours before taking an antacid. In the presence of aluminum hydroxide and magnesium hydroxide contained in the Gastal preparation, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%. In the presence of antacids, the bioavailability of captopril is significantly reduced, and the combined use of antacids and metoprolol leads to a decrease in plasma plasma concentration of metoprolol. With the simultaneous use of antacids in high doses, a decrease in the absorption of ranitidine is possible 10-33%. The use of antacids does not affect the bioavailability of amoxicillin, cefalexin and the combination of amoxicillin and clavulanic acid, but it can significantly reduce the absorption of doxycycline from the gastrointestinal tract. Increasing the pH of urine during antacid therapy can increase tubular reabsorption of alkaline drugs and reduce the reabsorption of alkaline drugs and reduce the reabsorption of alkaline drugs and reduce the reabsorption of alkaline drugs and the reabsorption of alkaline drugs. compounds. Antacids can reduce and slow down the absorption of salicylates, incl. acetylsalicylic acid, as well as raising the urine pH, to promote more rapid elimination of salicylates from the body, with a concomitant decrease in their concentration in serum by 30-70%. Absorption of cardiac glycosides, including digoxin and digitoxin, while used with antacids does not significantly decrease. M-cholinoblockers, slowing down the motility of the stomach, increase the duration of Gastal. To prevent possible interaction of Gastal with other drugs, it is recommended to take it 1 hour before or 1 hour after application.
special instructions
Do not exceed the recommended dose and duration of treatment when used in patients with impaired renal function. Effects on the ability to drive vehicles and control mechanismsThe use of the drug Gastal does not affect the ability to drive vehicles and control other mechanisms.