Halidor solution for intravenous and intramuscular administration of the ampoule 50 mg ml 2 ml N10
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Composition
1 ml of 1 amp. Bentsiklana fumarat 25 mg 50 mg. Excipients: sodium hydroxide - 1.783 mg, sodium chloride - 6.9 mg, water d / and - 988.317 mg.
Pharmacological effect
Myotropic antispasmodic with a pronounced vasodilating action. The vasodilating action of the bentsklan is mainly associated with its ability to block calcium channels, the antiserotonin action, and to a lesser extent with the blockade of sympathetic ganglia. Bentsyklan can cause dose-dependent suppression of Na + / K + -dependent ATPase and platelet aggregation and erythrocytes, as well as increasing the elasticity of erythrocytes. These effects are observed mainly in peripheral vessels, coronary arteries and cerebral vessels. In addition, the benziklan has a spasmolytic effect on the visceral muscles (gastrointestinal tract, urinary tract, respiratory organs). The drug causes some increase in heart rate. Its weak tranquilizing effect is also known.
Indications
Vascular diseases: - peripheral vascular diseases - Raynaud's disease, other diseases with acrocyanosis and vascular spasm, as well as chronic arterial occlusive disease. - cerebral vascular diseases: in the treatment of acute and chronic cerebral ischemia. Elimination of internal organs spasms: - gastrointestinal diseases - gastroenteritis of various etiologies (especially infectious), infectious and inflammatory colitis, functional diseases of the large intestine, tenesmus, postoperative flatulence, cholecystitis, cholelithiasis, state after cholecystectomy, motor disturbances in sphincter sphincter dyskinesia, peptic ulcer and duodenal ulcer (as part of combination therapy). - urological syndromes: spasms and tenesmus of the bladder, concomitant therapy of urolithiasis (in combination with analgesics for renal colic). Preparation for instrumental methods of research in urology.
Contraindications
- severe respiratory failure - severe renal failure - severe liver failure - decompensated heart failure - acute myocardial infarction - AV blockade - epilepsy and other forms of spasmophilia - recent hemorrhagic stroke - head injury (during the last 12 months) - pregnancy - lactation period(breastfeeding) - children and adolescents under 18 years of age (insufficient experience in use) - hypersensitivity to the components of the drug.
Use during pregnancy and lactation
The data of preclinical studies did not reveal any embryotoxic or teratogenic effects, however, adequate and strictly controlled clinical studies on the use of the drug Halidor during pregnancy and lactation were not carried out. Therefore, the introduction of the drug in patients in the first trimester of pregnancy is not recommended. If necessary, the use of the drug during lactation should decide on the termination of breastfeeding during treatment.
Dosage and administration
Vascular diseases. Inside Halidor is prescribed 100 mg 3 times / day for 2-3 months. The maximum daily dose for oral administration is 400 mg. The interval between courses is 2-3 months. The drug can also be used in the form of intravenous infusion in a daily dose of 200 mg, divided into 2 administrations. Before the infusion, 100 mg (4 ml) of the drug is diluted in 100-200 ml of isotonic sodium chloride solution and injected into / into the drip for 1 hour 2 times / day. To eliminate the spasm of internal organs. Inside Halidor is prescribed in a dose of 100-200 mg once, but not more than 400 mg / day. For maintenance therapy, 100 mg is prescribed 3 times / day for 3-4 weeks, then 100 mg 2 times / day. The duration of treatment is determined individually depending on the disappearance of the symptoms of the disease and, as a rule, does not exceed 1-2 months. In acute cases, Halidor is administered IV slowly in a dose of 100–200 mg (4–8 ml) or intramuscularly in a dose of 50 mg (2 ml). Before the on / in the introduction of the required amount of solution diluted with isotonic sodium chloride solution to 10-20 ml. The course of treatment is 2-3 weeks with the subsequent transfer of the patient, if necessary, to the intake of the drug Halidor.
Side effects
On the part of the digestive system: dry mouth, abdominal pain, a feeling of satiety, nausea, vomiting, increased serum liver transaminases. From the side of the central nervous system: anxiety, dizziness, headache, gait disturbance, tremor, sleep disturbances, insomnia, memory disorders. rarely - transient confused state of consciousness, epileptiform seizures, hallucinations. in isolated cases - symptoms of focal CNS damage.Since the cardiovascular system: sometimes - atrial and ventricular tachyarrhythmia (especially when combined with other proarrhythmic drugs). Other: general malaise, weight gain, leukopenia, allergic reactions. rarely - thrombophlebitis with a / in the introduction.
special instructions
On the part of the digestive system: dry mouth, abdominal pain, a feeling of satiety, nausea, vomiting, increased serum liver transaminases. From the side of the central nervous system: anxiety, dizziness, headache, gait disturbance, tremor, sleep disturbances, insomnia, memory disorders. rarely - transient confused state of consciousness, epileptiform seizures, hallucinations. in isolated cases - symptoms of focal CNS damage. Since the cardiovascular system: sometimes - atrial and ventricular tachyarrhythmia (especially when combined with other proarrhythmic drugs). Other: general malaise, weight gain, leukopenia, allergic reactions. rarely - thrombophlebitis with a / in the introduction.