Heparin Akrikhin 1000 gel for external. 30g

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Active ingredients

Sodium heparin

Release form



100 g of gel contains: Active substance: sodium heparin 100,000 IU (0.83 g). Adjuvants: methyl parahydroxybenzoate - 0.15 g, carbomer 940 - 1.25 mg, trometamol - 0.85 g, ethanol 96% (rectified ethyl alcohol) - 24 g, oil lavender - 0.02 g, orange flower oil (non-colic oil) - 0.01 g, purified water - up to 100 g

Pharmacological effect

Anticoagulant of direct action, belongs to the group of middle molecular heparins. in blood plasma, it activates antithrombin iii, accelerating its anticoagulant action. interferes with the transition of prothrombin to thrombin, inhibits the activity of thrombin and activated factor x, to some extent reduces platelet aggregation. increases the resistance of brain vessels, reduces the activity of cerebral hyaluronidase, activates lipoprotein lipase and has a lipid-lowering effect. reduces the activity of surfactant in the lungs, suppresses excessive aldosterone synthesis in the adrenal cortex, binds adrenaline, modulates the response of the ovaries to hormonal stimuli, enhances the activity of parathyroid hormone. as a result of interaction with enzymes, it can increase the activity of brain tyrosine hydroxylase, pepsinogen, dna polymerase, and reduce the activity of myosin atpase, pyruvate kinase, rna polymerase, pepsin. risk of developing acute coronary artery thrombosis, myocardial infarction and sudden death. reduces the frequency of recurrent heart attacks and the mortality of patients with myocardial infarction. in high doses it is effective in pulmonary embolism and venous thrombosis, in small doses - for the prevention of venous thromboembolism, including after surgical operations. when i / v administration, blood coagulation slows down almost immediately, with i / m - after 15-30 min, with s / c - after 20-60 min, after inhalation, the maximum effect - after a day; the duration of the anticoagulant action, respectively - 4-5, 6, 8 hours and 1-2 weeks., the therapeutic effect - prevention of thrombosis - lasts much longer.A deficiency of antithrombin III in plasma or in the place of thrombosis can decrease the antithrombotic effect of heparin. When applied topically, it has a local antithrombotic, anti-exudative, moderate anti-inflammatory effect. blocks the formation of thrombin, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of blood. Heparin penetrating the skin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the resorption of hematomas and blood clots and reducing the swelling of tissues.


After s / c administration of Cmax of the active substance in the plasma is observed after 3-4 hours. Heparin does not penetrate through the placenta due to its large molecular weight. Not excreted in breast milk. T1 / 2 from plasma is 30-60 minutes.


Thrombophlebitis of the superficial veins; localized infiltrates and soft tissue swelling; injuries of tendons and joints, bruises of soft tissues and joints.


Hypersensitivity to any of the components of the drug, ulcerative-necrotic changes in the skin at the sites of the intended application of the gel, traumatic violation of the integrity of the skin, reduced blood clotting, thrombocytopenia.

Precautionary measures

Keep out of the reach of children.

Use during pregnancy and lactation

Use during pregnancy is possible only under strict indications, under close medical supervision. It is possible to use during lactation (breastfeeding) according to indications.

Dosage and administration

Outwardly. The gel is applied with a thin layer on the affected area at the rate of 3-5 cm of gel on the skin area with a diameter of 3-5 cm and gently rubbed into the skin. Apply 1-3 times a day every day until the disappearance of inflammation, on average from 3 to 7 days. The duration of treatment is determined by the doctor.

Side effects

Allergic skin reactions, skin hyperemia.

Interaction with other drugs

The anticoagulant effect of heparin increases with the simultaneous use of anticoagulants, antiplatelet agents and NPVS. Ergot alkaloids, thyroxin, tetracycline, antihistamines, as well as nicotine reduce the effect of heparin.

special instructions

Use with caution in patients suffering from polyvalent allergies (including with bronchial asthma), with hypertension, dental procedures, diabetes, endocarditis, pericarditis, with intrauterine contraceptive, with active tuberculosis, radiation therapy, liver failure, chronic renal failure, in elderly patients (over 60 years old, especially women). It is not recommended in the / m administration of heparin due to the possibility of the development of hematoma, as well as in / m the introduction of other drugs during treatment with heparin. With caution, they are used externally for bleeding and conditions of increased bleeding, thrombocytopenia. During treatment with heparin, blood clotting indicators must be monitored. or below 100,000 / mcL), it is urgent to stop using heparin. The risk of bleeding can be minimized with careful evaluation of contraindications regular laboratory monitoring of blood coagulation and adequate dosing.