Hydroxycarbamide Medak Capsules 500mg N100
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Active ingredients
Hydroxycarbamide
Composition
1 caps hydroxycarbamide 500 mg. Auxiliary substances: polyoxyl 35 castor oil (macrogol glycerylhydroxystearate), ethanol anhydrous.
Indications
Pharmacokinetics
Contraindications
- chronic myeloid leukemia. - true polycythemia (erythremia). - Essential thrombocythemia. - osteomyelofibrosis. - melanoma. - malignant tumors of the head and neck, with the exception of lip cancer (in combination with radiation therapy). - cervical cancer (in combination with radiation therapy).
Dosage and administration
pharmachologic effect
Side effects
When choosing a regimen and doses in each individual case, you should be guided by the data of special literature. The drug is used inside. If swallowing is difficult, you can open the capsule, dissolve the contents in a glass of water and drink it whole. However, some water-insoluble auxiliary substances can float on the surface of the solution. During treatment with the drug should take a sufficiently large amount of fluid. Solid tumors - 80 mg / kg once a day every three days (6-7 doses). - 20-30 mg / kg daily for 3 weeks. Head and neck carcinoma, cervical carcinoma 80 mg / kg once a day, every third day in combination with radiation therapy. Drug treatment begins no less than 7 days before the start of radiation therapy and continue during radiation therapy. After radiation therapy, the drug continues to be taken for an unlimited time with strict observation of the patient and in the absence of unusual or severe toxicity reactions. Resistant chronic myeloid leukemia. Continuous therapy. From 20 to 30 mg / kg daily once a day. Evaluation of the effectiveness of the drug is carried out after 6 weeks of treatment. In case of severe clinical remission, treatment can be continued indefinitely. Treatment should be suspended if the leukocyte count is less than 2500 / mm3 and platelets are less than 100000 / mm3. After 3 days, the blood test is repeated. Treatment is resumed when the content of leukocytes and red blood cells begins to increase markedly. True polycythemia Treatment begins with a daily dose of 15-20 mg / kg. The dose is set individually, seeking to maintain the hematocrit at a level below 45%, and the number of platelets - below 400000 / mcl.In most patients, it is possible to achieve these indicators by constantly applying hydroxycarbamide at a daily dose of 500 to 1000 mg. Essential thrombocythemia Usually, the drug is prescribed in an initial daily dose of 15 mg / kg. then a dose is selected that maintains the number of platelets below 600000 / μl, without leading to a decrease in the number of white blood cells below 4000 / μl.
special instructions
When choosing a regimen and doses in each individual case, you should be guided by the data of special literature. The drug is used inside. If swallowing is difficult, you can open the capsule, dissolve the contents in a glass of water and drink it whole. However, some water-insoluble auxiliary substances can float on the surface of the solution. During treatment with the drug should take a sufficiently large amount of fluid. Solid tumors - 80 mg / kg once a day every three days (6-7 doses). - 20-30 mg / kg daily for 3 weeks. Head and neck carcinoma, cervical carcinoma 80 mg / kg once a day, every third day in combination with radiation therapy. Drug treatment begins no less than 7 days before the start of radiation therapy and continue during radiation therapy. After radiation therapy, the drug continues to be taken for an unlimited time with strict observation of the patient and in the absence of unusual or severe toxicity reactions. Resistant chronic myeloid leukemia. Continuous therapy. From 20 to 30 mg / kg daily once a day. Evaluation of the effectiveness of the drug is carried out after 6 weeks of treatment. In case of severe clinical remission, treatment can be continued indefinitely. Treatment should be suspended if the leukocyte count is less than 2500 / mm3 and platelets are less than 100000 / mm3. After 3 days, the blood test is repeated. Treatment is resumed when the content of leukocytes and red blood cells begins to increase markedly. True polycythemia Treatment begins with a daily dose of 15-20 mg / kg. The dose is set individually, seeking to maintain the hematocrit at a level below 45%, and the number of platelets - below 400000 / mcl. In most patients, it is possible to achieve these indicators by constantly applying hydroxycarbamide at a daily dose of 500 to 1000 mg. Essential thrombocythemia Usually, the drug is prescribed in an initial daily dose of 15 mg / kg. then a dose is selected that maintains the number of platelets below 600000 / μl, without leading to a decrease in the number of white blood cells below 4000 / μl.