Buy Indomethacin Sofarma suppositories rectal 100mg N6

Indomethacin Sofarma suppositories rectal 100mg N6

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Active ingredients

Indomethacin

Release form

Suppositories

Composition

Rectal suppositories 1 supp. Indomethacin 100 mg.

Pharmacological effect

NSAIDs, indole acetic acid derivative. It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is associated with inhibition of the COX enzyme, which leads to inhibition of the synthesis of prostaglandins from arachidonic acid. Suppresses platelet aggregation. When administered orally and parenterally, it helps relieve pain, especially pain in the joints at rest and when moving, reduce morning stiffness and swelling of the joints, and increase the range of motion. Anti-inflammatory effect develops by the end of the first week of treatment. When applied topically, it eliminates pain, reduces swelling and erythema. When applied externally, in addition, it helps to reduce morning stiffness and increase range of motion.

Indications

For systemic use: articular syndrome (including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of soft tissues and joints, rheumatism, diffuse diseases of the connective tissue, dysmenorrhea. As an adjuvant in infectious and inflammatory diseases of the upper respiratory tract, adnexitis, prostatitis, cystitis. For local use: prevention of inflammation during surgery for cataracts and in the anterior segment of the eye, inhibition of miosis during surgery. For external use: articular syndrome (including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout), pain in the spine, neuralgia, myalgia, traumatic inflammation of the soft tissues and joints.

Contraindications

Hypersensitivity to indomethacin, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, aspirin triad, impaired blood formation, marked impaired liver and / or kidney function, severe forms of chronic heart failure, arterial hypertension, pancreatitis, third trimester of pregnancy, children under 14 let for rectal administration: proctitis, recent rectal bleeding.

Use during pregnancy and lactation

Indomethacin is contraindicated in the third trimester of pregnancy.In the I and II trimesters of pregnancy, as well as during lactation (breastfeeding) use is not recommended. Indomethacin in small quantities excreted in breast milk.

Dosage and administration

Set individually, taking into account the severity of the disease. For adults with oral intake, the initial dose is 25 mg 2-3 times / day. With insufficient severity of the clinical effect, the dose is increased to 50 mg 3 times / day. Dosage forms of prolonged action used 1-2 times / day. Maximum daily dose: 200 mg. When effect is achieved, treatment is continued for 4 weeks in the same or reduced dose. With prolonged use, the daily dose should not exceed 75 mg. Accept after meals. For the treatment of acute conditions or the relief of exacerbation of a chronic process, intramuscular injection of 60 mg is administered 1-2 times / day. The duration of the / m introduction - 7-14 days. Then indomethacin is used inside or rectally in 50-100 mg 2 times / day, while the maximum daily dose should not exceed 200 mg. For maintenance treatment is used rectally, 50-100 mg 1 time per day for the night. For local use in ophthalmology, the dose frequency and duration of use are determined individually. Outwardly used 2 times / day.

Side effects

On the part of the digestive system: nausea, anorexia, vomiting, pain and discomfort in the stomach, constipation or diarrhea, erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract. rarely - intestinal strictures, stomatitis, gastritis, flatulence, bleeding from the sigmoid colon or diverticulum, jaundice, hepatitis. On the part of the central nervous system and peripheral nervous system: dizziness, headache, depression, fatigue. rarely - anxiety, fainting, drowsiness, convulsions, peripheral neuropathy, muscle weakness, involuntary muscle movements, sleep disorders, mental disorders (depersonalization, psychotic episodes), paresthesia, dysarthria, parkinsonism. Since the cardiovascular system: edema, increased blood pressure, tachycardia, chest pain, arrhythmia, palpitation, arterial hypotension, congestive heart failure, hematuria. Allergic reactions: rarely - pruritus, urticaria, angiitis, erythema nodosum, skin rash, exfoliative dermatitis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, hair loss, acute respiratory distress, a sharp drop in blood pressure, anaphylactic reactions, anaphylactic reactions, and an anmathylactic reactions, and I have to use an aphrodisopathy. , bronchial asthma, pulmonary edema.On the part of the hematopoietic system: rarely - leukopenia, petechiae or ecchymosis, purpura, aplastic and hemolytic anemia, thrombocytopenia, DIC syndrome. On the part of the senses: rarely - impaired clarity of visual perception, diplopia, orbital and periorbital pain, tinnitus, hearing impairment, deafness. From the urinary system: rarely - proteinuria, nephrotic syndrome, interstitial nephritis, renal dysfunction, renal failure. Metabolism: rarely - hyperglycemia, glycosuria, hyperkalemia. Other: rarely - vaginal bleeding, hot flashes, increased sweating, nosebleeds, an increase and tension of the mammary glands, gynecomastia. Local reactions: in the place of intramuscular administration, in some cases - the formation of infiltration, abscess. with rectal use, irritation of the rectal mucosa, tenesmus, exacerbation of chronic colitis are possible. When applied topically: itching, redness, rash at the site of application.

special instructions

On the part of the digestive system: nausea, anorexia, vomiting, pain and discomfort in the stomach, constipation or diarrhea, erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract. rarely - intestinal strictures, stomatitis, gastritis, flatulence, bleeding from the sigmoid colon or diverticulum, jaundice, hepatitis. On the part of the central nervous system and peripheral nervous system: dizziness, headache, depression, fatigue. rarely - anxiety, fainting, drowsiness, convulsions, peripheral neuropathy, muscle weakness, involuntary muscle movements, sleep disorders, mental disorders (depersonalization, psychotic episodes), paresthesia, dysarthria, parkinsonism. Since the cardiovascular system: edema, increased blood pressure, tachycardia, chest pain, arrhythmia, palpitation, arterial hypotension, congestive heart failure, hematuria. Allergic reactions: rarely - pruritus, urticaria, angiitis, erythema nodosum, skin rash, exfoliative dermatitis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, hair loss, acute respiratory distress, a sharp drop in blood pressure, anaphylactic reactions, anaphylactic reactions, and an anmathylactic reactions, and I have to use an aphrodisopathy. , bronchial asthma, pulmonary edema.On the part of the hematopoietic system: rarely - leukopenia, petechiae or ecchymosis, purpura, aplastic and hemolytic anemia, thrombocytopenia, DIC syndrome. On the part of the senses: rarely - impaired clarity of visual perception, diplopia, orbital and periorbital pain, tinnitus, hearing impairment, deafness. From the urinary system: rarely - proteinuria, nephrotic syndrome, interstitial nephritis, renal dysfunction, renal failure. Metabolism: rarely - hyperglycemia, glycosuria, hyperkalemia. Other: rarely - vaginal bleeding, hot flashes, increased sweating, nosebleeds, an increase and tension of the mammary glands, gynecomastia. Local reactions: in the place of intramuscular administration, in some cases - the formation of infiltration, abscess. with rectal use, irritation of the rectal mucosa, tenesmus, exacerbation of chronic colitis are possible. When applied topically: itching, redness, rash at the site of application.

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