Ingaron lyophilisate solution nasal 100k IU N1 + solvent
Condition: New product
949 Items
More info
Description
Ingaron is an effective antiviral and immunomodulatory drug. It is used in the treatment and prevention of colds, ARVI, flu.
Active ingredients
Release form
Composition
Pharmacological effect
INGARON® is a recombinant human interferon gamma, consists of 144 amino acid residues (a. O.), Is deprived of the first three a. about. Cys-Tyr-Cys replaced with Met. Molecular weight is 16.9 kDa. Obtained by microbiological synthesis in recombinant Escherichia coli strain and purified by column chromatography. The specific antiviral activity on cells (human fibroblasts) infected with vesicular stomatitis virus is 2 ∙ 107 U / mg protein.
Interferon gamma (immune interferon) is the most important pro-inflammatory cytokine, produced in the human body by natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells. Interferon gamma receptors have macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes. Activates the effector functions of these cells, in particular their microbicidal activity, cytotoxicity, their production of cytokines, superoxide and nitroxide radicals (thereby causing the death of intracellular parasites). Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. At the same time, it causes a cytotoxic effect on virus-infected cells.
Inhibits the B-cell response to interleukin-4, inhibits the production of IgE and the expression of CD23 antigen. It is an inducer of apoptosis of differentiated B cells, giving rise to autoreactive clones. It cancels the suppressive effect of interleukin-4 on interleukin-2-dependent proliferation and generation of activated killer lymphokine. Activates the production of proteins of the acute phase of inflammation, enhances the expression of the C2 and C4 genes of the components of the complement system.
Unlike other interferons, it increases the expression of GCGS antigens of both I and II classes on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively. This increases the efficiency of the presentation of antigens and the ability of their recognition by T-lymphocytes.
Interferon gamma blocks the synthesis of β-TGF, which is responsible for the development of fibrosis of the lungs and liver.
Indications
Prevention and treatment (as part of complex therapy) of the H5N1 and H1N1 flu.
Contraindications
Individual intolerance to interferon gamma or any other component of the drug. Pregnancy. Children's age (under 7 years).
Dosage and administration
Intranasal. The contents of the vial are dissolved in 5 ml of water for injection.
At the first signs of flu, ARVI, 2 drops in each nasal passage after the toilet of the nasal passages 5 times a day for 5-7 days.
For the prevention of SARS and influenza in contact with the patient and / or hypothermia 2-3 drops in each nasal passage every other day for 10 days. If necessary, preventive courses are repeated. With a single contact, a single instillation is sufficient.
After instillation, it is recommended to massage the wings of the nose with your fingers for a few minutes to evenly distribute the drug in the nasal cavity.
Side effects
Not noted.
Interaction with other drugs
special instructions
Storage conditions
In a dry, dark place and out of reach of children, at a temperature not higher than + 25ºС.
Store the drug solution for no more than 10 days in the refrigerator (do not freeze).