Ivan tea grass filter package 1.5g N20
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Active ingredients
Calendula officinalis flowers
Composition
Warfarin sodium 2.5 mg.
Pharmacological effect
Indirect anticoagulant, coumarin derivative. Inhibits the synthesis of vitamin K-dependent coagulation factors (II, VII, IX and X) and anticoagulant proteins C and S in the liver.
Indications
Treatment and prevention of thrombosis of the vascular system possible combination with acetylsalicylic acid) peripheral thrombosis, to coronary and cerebral arteries in the secondary prevention of thrombosis and thromboembolism after myocardial infarction and atrial fibrillation.
Contraindications
Diseases and conditions with a high risk of bleeding, pathological changes in the blood. Recent traumatic brain surgery, ophthalmic surgery, trauma surgery with extensive surgical field. The tendency to bleeding in ulcerative lesions of the gastrointestinal tract, in diseases of the urogenital system, the respiratory system cerebrovascular hemorrhagia and aneurysm pericarditis, exudative pericarditis, bacterial endocarditis. Severe liver or kidney disease, severe hypertension, acute DIC. Threatening abortion, pregnancy. Inadequate laboratory conditions for monitoring the patient, lack of monitoring for elderly patients, alcoholism, psychosis, patient disorganization. Spinal puncture and other diagnostic procedures with the potential threat of uncontrolled bleeding. Extensive regional anesthesia, carrying out the blockade. Malignant arterial hypertension.
Use during pregnancy and lactation
Warfarin is contraindicated in pregnancy. Easily penetrates the placental barrier and can cause hemorrhagic disorders in the fetus, as well as abnormal bone development. Warfarin is excreted in inactive form with breast milk.In infants, whose mothers received warfarin during the breastfeeding period, no changes in prothrombin time were detected. The effects of warfarin in preterm infants have not been studied.
Dosage and administration
Individual, depending on the parameters of blood coagulation, the patient's response to treatment, the clinical situation. Is taken orally at a dose of 2-10 mg / day.
Side effects
On the part of the blood coagulation system: bleeding, hematoma, anemia. rarely, necrosis of the skin and other tissues due to local thrombosis. Dermatological reactions: dermatitis, bullous rash, alopecia. On the part of the digestive system: nausea, vomiting, diarrhea, abdominal pain, hepatitis, cholestasis, jaundice, increased activity of liver enzymes. Since the cardiovascular system: purple staining of the toes, vasculitis, feeling of cold, chills, paresthesia. From the side of the central nervous system: fatigue, lethargy, asthenia, headache, dizziness, taste disturbances. On the part of the respiratory system: rarely - tracheal or tracheal-bronchial calcification with long-term therapy (clinical significance has not been established). Allergic reactions: skin rash, swelling, fever, urticaria, pruritus.
special instructions
On the part of the blood coagulation system: bleeding, hematoma, anemia. rarely, necrosis of the skin and other tissues due to local thrombosis. Dermatological reactions: dermatitis, bullous rash, alopecia. On the part of the digestive system: nausea, vomiting, diarrhea, abdominal pain, hepatitis, cholestasis, jaundice, increased activity of liver enzymes. On the part of the cardiovascular system: purple staining of the toes, vasculitis, feeling cold, chills, paresthesia. From the side of the central nervous system: fatigue, lethargy, asthenia, headache, dizziness, taste disturbances. On the part of the respiratory system: rarely - tracheal or tracheal-bronchial calcification with long-term therapy (clinical significance has not been established). Allergic reactions: skin rash, swelling, fever, urticaria, pruritus.