More info
Active ingredients
Ketotifen
Release form
Pills
Composition
Active ingredient: Ketotifen Concentration of active ingredient (mg): 1 mg
Pharmacological effect
Antiallergic means. The mechanism of action is associated with the stabilization of mast cell membranes and a decrease in the release of histamine, leukotrienes and other biologically active substances from them. Suppresses platelet activating factor-induced accumulation of eosinophils in the airways. Prevents attacks of bronchial asthma, some other manifestations of allergic reactions of immediate type. Blocks histamine H1 receptors.
Pharmacokinetics
After ingestion is almost completely absorbed from the gastrointestinal tract. A simultaneous meal does not affect the degree of absorption of ketotifen. Metabolized by 50% during the first passage through the liver. Cmax in blood plasma is achieved within 2-4 hours. Plasma protein binding is 75%. It appears biphasic. T1 / 2 in the initial phase is 3-5 hours, in the final phase - 21 hours. It is excreted by the kidneys, 60-70% as metabolites, 1% - unchanged.
Indications
Atopic asthma, pollinosis (hay fever), allergic rhinitis, allergic conjunctivitis, atopic dermatitis, urticaria.
Contraindications
Hypersensitivity, pregnancy, lactation, children under 3 years. With caution - epilepsy, liver failure.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
In pregnancy, especially in the first trimester, the use is possible only if the potential benefit to the mother outweighs the possible risk to the fetus. Ketotifen enters breast milk, so if you need to use it during lactation, you should decide whether to stop breastfeeding.
Dosage and administration
Inside, during meals, adults - 1 mg 2 times a day, morning and evening. If necessary, increase the dose to 2 mg 2 times a day. Children from 3 years and older - 1 mg 2 times a day. The duration of treatment is at least 3 months. The abolition of therapy is carried out gradually, within 2-4 weeks.
Side effects
On the part of the nervous system: drowsiness, dizziness, slowdown of the reaction rate (disappear after a few days of therapy), sedation, fatigue; rarely - anxiety, sleep disturbances, nervousness (especially in children). On the part of the digestive system: dry mouth, increased appetite, nausea, vomiting, gastralgia, constipation. On the part of urination: dysuria, cystitis.Other: thrombocytopenia, weight gain, allergic skin reactions.
Overdose
No cases of drug overdose have been reported.
Interaction with other drugs
Ketotifen may enhance the effects of sedatives, hypnotics, antihistamines and ethanol. When taking ketotifen simultaneously with oral hypoglycemic drugs, there was a reversible decrease in platelet count.
special instructions
The therapeutic effect of ketotifen develops slowly over 1-2 months. The ongoing anti-asthma therapy should be continued for at least 2 weeks after the start of ketotifen. The simultaneous use of ketotifen and bronchodilators can sometimes decrease the dose of the latter. Effect on ability to drive Vehicles and machinery management Patients taking ketotifen should refrain from potentially hazardous activities associated with the need for increased attention and speed s psychomotor reactions.