Lidaza powder lyophilisate for injection 64ed ampoules N10
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Active ingredients
Hyaluronidase
Release form
Solution
Composition
1 bottle contains: hyaluronidase 64 IU. Solvent: solution of sodium chloride 0.9% - 2 ml.
Pharmacological effect
Enzyme agent isolated from the testes of cattle. Breaks down the main component of the interstitial substance of connective tissue - hyaluronic acid (mucopolysaccharide, which consists of acetylglucosamine and glucuronic acid, is a cementing substance of connective tissue). Hyaluronidase causes the breakdown of hyaluronic acid to glucosamine and glucuric acid and thereby reduces its viscosity. Increases tissue and vascular permeability, facilitates the diffusion of fluids in the interstitial space. Reduces swelling of the tissue, softens and flattens scars, increases the range of motion in the joints, reduces contractures and prevents their formation.
Pharmacokinetics
Data on the pharmacokinetics of the drug is not provided.
Indications
Burn, traumatic, postoperative scars; nonhealing ulcers (including radiation); Dupuytren's contracture; joint stiffness, joint contractures, (after inflammatory processes, injuries), osteoporosis, ankylosing spondyloarthritis, severe lumbar disc disease; chronic tendovaginitis, scleroderma (skin manifestations), hematoma of soft tissues of superficial localization; preparation for skin-plastic surgery for cicatricial contractions. Pulmonary tuberculosis (complicated by nonspecific bronchial lesions), inflammatory processes in the upper respiratory tract and bronchi with symptoms of obstruction. Traumatic lesions of the nerve plexus and peripheral nerves (plexitis, neuritis). Hyphema, hemophthalmus, retinopathy of various etiologies.
Contraindications
Hypersensitivity, acute infectious and inflammatory diseases, recent hemorrhages, acute intercurrent diseases, children under 18 years of age. For inhalation - pulmonary tuberculosis with severe respiratory failure; pulmonary, bleeding, hemoptysis; malignant neoplasms, fresh vitreous hemorrhage.Concomitant use of estrogen. Data on the use of the drug in children are missing
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
Use caution during pregnancy and lactation.
Dosage and administration
For cicatricial lesions, subcutaneously (under the scar-modified tissue) or intramuscularly (near the site of the lesion) are administered at 64 UE (1 ml) daily or every other day (10-20 injections). When traumatic lesions of the nerve plexus and peripheral nerves are injected subcutaneously in the region of the affected nerve (64 UE in a solution of procaine) every other day; for the course - 12-15 injections. The course of treatment is repeated if necessary. When used in ophthalmic practice, the drug is administered subconjunctivally - 0.3 ml, parabulbarno - 0.5 ml, as well as by electrophoresis. Patients with pulmonary tuberculosis with a productive inflammation are prescribed in complex therapy to increase the concentration of antibacterial drugs in the lesions in the form of injections and / or inhalations! Inhalation is carried out daily 1 time, using 5 ml of solution (320 UE). The course of treatment consists of 20-25 inhalations. If necessary, repeat courses are conducted at intervals of 1.5-2 months. Outwardly, in the form of dressings soaked in a solution of the drug. To prepare a solution, every 64 UE is dissolved in 10 ml of sterile 0.9% sodium chloride solution or boiled water at room temperature. This solution moistened with a sterile dressing, folded in 4-5 layers, put it on the affected area, covered with wax paper and fixed with a soft dressing. The dose depends on the area of the lesion (20-60 IU / sq. Cm), on average - 300 ME per dressing. The bandage is applied daily for 15-18 h for 15-60 days. With prolonged use every 2 weeks, make a break for 3-4 days. When using the method of electrophoresis 300 ME dissolved in 60 ml of distilled water, add 2-3 drops of 0.1% solution of hydrochloric acid and injected from the anode to the affected area for 20-30 minutes The course of treatment is 15-20 sessions. The application mode dosing can be alternated with electrophoresis. The prepared solution should be used within 24 hours.
Side effects
Allergic reactions; with prolonged use - local irritating action.
Overdose
Cases of overdose are not described.
Interaction with other drugs
Hyaluronidase improves the absorption of drugs injected s / c or v / m, accelerates pain relief with the introduction of local anesthetics. With caution should be used in combination with other drugs, because possible unpredictable increase in absorption and increased systemic effects.
special instructions
The solution should not be injected through a catheter into which solutions containing cations were previously injected. Before starting treatment, it is advisable to perform a test with a / c injection of hyaluronidase. It should not be injected into areas of infectious inflammation and tumors.